Gap junctions and other mechanisms of cell–cell communication regulate basal insulin secretion in the pancreatic islet

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Items 101–165 of 165

1. Notch-mediated Ephrin signaling disrupts islet architecture and β cell function
   Alberto Bartolomé, Nina Suda, Junjie Yu, Changyu Zhu, Jinsook Son, Hongxu Ding, Andrea Califano, Domenico Accili, Utpal B. Pajvani · 2022 · JCI Insight
2. Integrated multiscale mathematical modeling of insulin secretion reveals the role of islet network integrity for proper oscillatory glucose-dose response
   I. Johanna Stamper, Xujing Wang · 2019 · Journal of Theoretical Biology
3. Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
   Samantha E. Adamson, Zi-Peng A. Li, Jing W. Hughes · 2023 · Islets
4. Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis
   Marko Šterk, Yaowen Zhang, Viljem Pohorec, Eva Paradiž Leitgeb, Jurij Dolenšek, Richard K.P. Benninger, Andraž Stožer, Vira V. Kravets, Marko Gosak · 2024 · PLoS Computational Biology
5. Glucose inhibits glucagon secretion by decreasing [Ca2+]c and by reducing the efficacy of Ca2+ on exocytosis via somatostatin-dependent and independent mechanisms
   Bilal Singh, Firas Khattab, P. Gilon · 2022 · Molecular Metabolism
6. Long‐term exercise preserves pancreatic islet structure and β‐cell mass through attenuation of islet inflammation and fibrosis
   Vladmir Carvalho, Qianqian Wang, Xiaohan Xu, Lijie Liu, Weixin Jiang, Xiaohang Wang, Jinbang Wang, Wei Li, Juan Chen, Tingting Li et al. · 2023 · The FASEB Journal
7. Modeling K,ATP-Dependent Excitability in Pancreatic Islets
   Jonathan R. Silva, Paige Cooper, Colin G. Nichols · 2014 · Biophysical Journal
8. Intercellular Communication in the Islet of Langerhans in Health and Disease
   Xue-Wen Ng, Hee-Chung Yong, D. W. Piston · 2021 · Comprehensive Physiology
9. A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models
   Gerardo J. Félix‐Martínez, José Rafael Godínez-Fernández · 2023 · Islets
10. Restoring connexin‐36 function in diabetogenic environments precludes mouse and human islet dysfunction
    Joshua R. St. Clair, Matthew J. Westacott, Jose Miranda, Nikki L. Farnsworth, Vira V. Kravets, Wolfgang E. Schleicher, JaeAnn M. Dwulet, Claire H Levitt, Audrey Heintz, Nurin W.F. Ludin et al. · 2023 · The Journal of Physiology
11. A low-protein diet during pregnancy prevents modifications in intercellular communication proteins in rat islets
    Ana Flávia Marçal Pessoa, Carmen Lucia Bassi-Branco, CRISTIANA S.B. SALVATIERRA, Luiz Fabrízio Stoppiglia, Letícia Martins Ignácio-Souza, Sílvia Regina de Lima Reis, Roberto Vilela Veloso, Marise Auxiliadora de Barros Reis, Everardo M. Carneiro, Antonio Carlos Boschero et al. · 2015 · Biological Research
12. A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome
    Ronit Vogt Sionov, Ronit Ahdut-HaCohen · 2023 · Biomedicines
13. The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.
    Maryam Saadati, Y. Jamali · 2020 · Scientific Reports
14. Pancreatic Crosstalk in the Disease Setting: Understanding the Impact of Exocrine Disease on Endocrine Function
    Catharina B.P. Villaca, Teresa L. Mastracci · 2024 · Comprehensive physiology
15. Desmoglein-2 is important for islet function and β-cell survival
    Kay K. Myo Min, Darling Macarena Rojas‐Canales, Daniella Penko, Mark O. DeNichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Chris Drogemuller, Rashmi B. Prasad et al. · 2022 · Cell Death and Disease
16. Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low-density Cx36 gap junctions
    Mohammad S. Pourhosseinzadeh, Jessica L. Huang, Donghan Shin, Ryan G. Hart, Luhaiza Y. Framroze, Jaresley V. Guillen, J.P. Marín Sánchez, Ramir V. Tirado, Kelechi Unanwa, Mark O. Huising · 2025 · Proceedings of the National Academy of Sciences
17. Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes
    Nikki L. Farnsworth, Robert A. Piscopio, Wolfgang E. Schleicher, David G. Ramirez, Jose G. Miranda, Richard K.P. Benninger · 2022 · Frontiers in Physiology
18. (Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells
    Firdos, Tapabrata Pramanik, Prachi Verma, Aditya Mittal · 2024 · ACS Omega
19. Impact of oxygen and glucose availability on the viability and connectivity of islet cells: A computational study of reconstructed avascular human islets
    Gerardo J. Félix‐Martínez, Diana Osorio-Londoño, José Rafael Godínez-Fernández · 2024 · PLoS Computational Biology
20. A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production
    Masson, Helen, Tat, Jasmine, Di Giusto, Pablo, Antonakoudis, Athanasios, Shamie, Isaac, Baghdassarian, Hratch, Samoudi, Mojtaba, Robinson, Caressa M., Kuo, Chih-Chung, Koga, Natalia et al. · 2025 · Cell Systems
21. Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate
    Michael A. Kalwat, Melanie H. Cobb · 2019 · Journal of Visualized Experiments
22. Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis
    Nelmari Ruiz-Otero, Rejji Kuruvilla · 2023 · Frontiers in Endocrinology
23. Tripartite cell networks for glucose homeostasis
    Taegeun Song, Junghyo Jo · 2019 · Physical Biology
24. Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective
    Julia Huey, Kaya Keutler, Carsten Schultz · 2020 · Cell chemical biology
25. Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress
    Mirabela Hali, Brian E. Wadzinski, Anjaneyulu Kowluru · 2022 · Molecular and Cellular Endocrinology
26. Connexins and microRNAs: Interlinked players in regulating islet function?
    Malati R. Umrani, Mugdha V. Joglekar, Ella Somerville Glover, Wilson K. M. Wong, Anandwardhan A. Hardikar · 2017 · Islets
27. BetaBuddy: An automated end-to-end computer vision pipeline for analysis of calcium fluorescence dynamics in β-cells
    Anne Alsup, Kelli Fowlds, Michael Cho, Jacob M. Luber · 2024 · PLoS ONE
28. Six degrees of depolarization
    Kyle C. A. Wedgwood, Leslie S. Satin · 2018 · Physics of Life Reviews
29. Breaking down calcium timing in heterogenous cells populations
    Alessandro Loppini, Christian Cherubini, Marta Bertolaso, Simonetta Filippi · 2020 · Biosystems
30. Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices
    Kelly M. T. Shekiro, Thomas H. Hraha, Abigail B. Bernard, Richard K.P. Benninger, Kristi S. Anseth · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
31. Investigating Oscillation Loss in Computational Islets
    Gemma Gearhart, Shuai Jiang, Thomas J. May, Jane Pan, Samuel Khuvis, Matthias K. Gobbert, Bradford E. Peercy, Arthur Sherman · 2013 · Maryland Shared Open Access Repository (USMAI Consortium)
32. Paracrine signaling by pancreatic islet cilia
    Samantha E. Adamson, Jing W. Hughes · 2024 · Current Opinion in Endocrine and Metabolic Research
33. Glucose-Dependent Insulin Secretion from β Cell Spheroids Is Enhanced by Embedding into Softer Alginate Hydrogels Functionalised with RGD Peptide
    Md Lutful Amin, Kylie Deng, Hien Anh Tran, Reena Singh, Jelena Rnjak‐Kovacina, Peter Thorn · 2022 · Bioengineering
34. Spatial distribution of heterogeneity as a modulator of collective dynamics in pancreatic beta-cell networks and beyond
    Daniel Galvis, David J. Hodson, Kyle C. A. Wedgwood · 2023 · Frontiers in Network Physiology
35. Pancreatic Crosstalk in the Disease Setting: Understanding the Impact of Exocrine Disease on Endocrine Function
    Catharina B.P. Villaca, Teresa L. Mastracci · 2024 · Comprehensive physiology
36. Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional β-cell subpopulations
    Claire H Levitt, Dominic P. Isaacs, Maria Skjøtt Hansen, Vira V. Kravets, Jennifer K. Briggs, Richard K.P. Benninger · 2026 · The Journal of General Physiology
37. Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
    M. Aggarwal, D. Striegel, M. Hara, V. Periwal · 2023 · PLoS Comput. Biol.
38. BetaBuddy: An end-to-end computer vision pipeline for the automated analysis of insulin secreting β-cells
    Anne Alsup, Kelli Fowlds, Michael Cho, Jacob M. Luber · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
39. Challenges and strategies in tissue engineering for improved β-cell replacement therapies through an understanding of normal pancreatic anatomy and physiology
    Nicole Kattner, P. Carlsson, W. Scott · 2021 · Journal of Immunology and Regenerative Medicine
40. Behavioral Pharmacology of Gap Junctions
    Grzegorz Roman Juszczak, Artur Hugo Swiergiel · 2012 · Elsevier eBooks
41. Dynamics of Computational Islet Simulations: Islets with majority mutated openKATPchannels retain bursting
    Gemma Gearhart, Shuai Jiang, Thomas J. May, Jane Pan, Samuel Khuyis, Matthias K. Gobbert, Bradford E. Peercy, Arthur Sherman · 2014 · Letters in Biomathematics
42. Critical transitions in pancreatic islets
    Dean Korošak, S. Postić, Andraž Stožer, Boris Podobnik A, Marjan Slak Rupnik · 2025 · Physical review. E
43. Network Analysis Applied to Pancreatic Islets
    Janita Patwardhan, Bradford E. Peercy · 2019 · Elsevier eBooks
44. Advanced Imaging Techniques for the Characterization of Subcellular Organelle Structure in Pancreatic Islet β Cells
    Madeline R. McLaughlin, Staci A. Weaver, Farooq Syed, Carmella Evans‐Molina · 2023 · Comprehensive physiology
45. F-Actin regulation of SNARE-mediated insulin secretion
    Michael A. Kalwat · 2013 · IUScholarWorks (Indiana University)
46. Islet composition and architecture in streptozotocin-induced diabetic rat following pancreatic duct ligation
    Patricia Clara Kotze · 2015 · SUNScholar (Stellenbosch University)
47. CFTR in pancreatic islets
    Anna Edlund · 2016 · Lund University Publications (Lund University)
48. Proceedings of the Australian Physiological Society Symposium Insulin secretion from beta cells within intact islets: Location matters
    Oanh Hoang Do, Peter Thorn · 2016
49. Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development
    Jing Liu · 2015
50. Paracrine regulation of glucagon secretion from pancreatic islets
    Amicia D. Elliott · 2014
51. Correlative Light and Electron Imaging of Cell-Cell Interactions within the Islet of Langerhans
    David W. Piston, Jing W. Hughes, Alessandro Ustione · 2017 · Microscopy and Microanalysis
52. Endoplasmic reticulum calcium dynamics and insulin secretion in pancreatic β cells
    Wataru R. Yamamoto · 2017 · IUScholarWorks (Indiana University)
53. Dynamics of Computational Islet Simulations: Islets with Majority Mutated Open
    Gemma Gearhart, Shuai Jiang, Thomas J. May, Jane Pan, Samuel Khuyis, Matthias K. Gobbert, Bradford E. Peercy, Arthur Sherman · 2014 · Letters in Biomathematics
54. The Effects of Beta-cell Mass and Function, Intercellular Coupling, and islet Synchrony on Ca2+ Dynamics in Patients with Type 2 Diabetes Mellitus
    Maryam Saadati, Y. Jamali · 2020 · Research Square
55. Development of a Platform for the Biofabrication of Endocrine Pancreatic Tissue Constructs through Co-Axial Micro-Extrusion
    Max Jurie Renes · 2020 · Research Online (University of Wollongong)
56. Glucose-stimulated calcium dynamics in beta cells from C57BL/6J, C57BL/6N, and NMRI mice: A systematic comparison of activation, activity, and deactivation properties in tissue slices
    Viljem Pohorec, L. K. Bombek, M. Klemen, J. Dolenšek, A. Stožer · 2022 · bioRxiv
57. Advanced Imaging Techniques for the Characterization of Subcellular Organelle Structure in Pancreatic Islet β Cells
    Madeline R. McLaughlin, Staci A. Weaver, Farooq Syed, Carmella Evans‐Molina · 2024 · Comprehensive physiology
58. Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of Alpha and Beta Cell Activity
    Jasmina Kerčmar, Nastja Murko, Lidija Križančić Bombek, Eva Paradiž Leitgeb, Johannes U. Pfabe, Sandra Postić, Ya‐Chi Huang, Andraž Stožer, Dean Korošak, Xaver Kozisek et al. · 2025 · eLife
59. Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses
    Jasmina Kerčmar, Nastja Murko, Lidija Križančić Bombek, Eva Paradiž Leitgeb, Johannes U. Pfabe, Sandra Postić, Ya‐Chi Huang, Andraž Stožer, Dean Korošak, Xaver Kozisek et al. · 2025 · eLife
60. Electrophysiology of pancreatic beta cells: a comprehensive review of ion channel function, electrical activity, and secretory mechanisms
    Aykut Oruç, Kadriye Yağmur Oruç, Mehmet Altan, Osman Fuat Sönmez, Semih Cin · 2025 · Troia Medical Journal
61. Additional file 1 of A Practical Guide to Rodent Islet Isolation and Assessment Revisited
    Kathryn L. Corbin, Hannah L. West, Samantha Brodsky, Nicholas B. Whitticar, William J. Koch, Craig S. Nunemaker · 2021 · Figshare
62. Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucose
    Ishan Goswami, J. P. Koepke, Masoud Baghelani, Patrick E. MacDonald, Vira V. Kravets, Peter E. Light, Andrew G. Edwards · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
63. Communications intercellulaires dynamiques au sein des îlots pancréatiques analysées par multi-electrode arrays : rôles physiologiques et applications biotechnologiques en diabétologie
    Manon Jaffredo · 2021 · theses.fr (ABES)
64. Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications
    Si-Yu Zhuang, XU Lu-jin, Hai-Xia Yang, Qi-Wei Yang, Geng Chen, Bin Xu, Zhi Yu, Yun Liu, Tian-Cheng Xu · 2026 · World Journal of Methodology
65. Emergent Synchronization and Structural Transitions in β Cell Networks: Insights from Spectral and Topological Dynamics
    Vijender Kalmotia · 2026 · Lecture notes in networks and systems