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Cited by 126Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchPharmacological Effects of Medicinal Plants

Effectiveness and utility of hyaluronic acid in osteoarthritis

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Migliore, A·2015·Clinical Cases in Mineral and Bone Metabolism
DOI 10.11138/ccmbm/2015.12.1.031PMC PMC4469223
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Abstract

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Viscosupplementation with intra-articular hyaluronic acid is a treatment option in knee OA that is included in the professional guidelines for treatment of this joint disease, but potentially should apply to all synovial joints in order to reduce pain and improve joint lubrication. Exogenous HA can enhance chondrocyte HA synthesis, prevent the degradation of cartilage and promote its regeneration. Moreover it can reduce the production of proinflammatory mediators and matrix metalloproteinases involved in OA pathogenesis. This mini review highlights the evidence of hyaluronic acid in reducing osteoarthritis symptoms and structural damage, as well as its ability to delay prosthetic surgery. Viscosupplementation should be considered as a long-term therapy.

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  • PN has shown favorable outcomes in improving knee function and alleviating pain without causing serious adverse effects.

    “In addition, PN has shown favorable outcomes in improving knee function and alleviating pain without causing serious adverse effects [42,43,44,45,46,47].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [42]

    The Introduction reports improved knee pain and function and low rates of adverse effects for hyaluronic acid (HA), not PN. A search for PN and polynucleotide treatment found no passage in our copy addressing PN’s outcomes or safety. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.

    “PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [42]

    The Introduction discusses intra-articular hyaluronic acid for osteoarthritis, not skin rejuvenation. Searches for polynucleotides, poly-L-lactic acid, skin texture, and synergistic combinations found no passage addressing the attributed claim; page numbers were not available in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 30

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Authors
Migliore, A.
Affiliations
Ospedale San Pietro Fatebenefratelli (IT)
Corresponding author
Migliore, A
ORCID
Migliore, A
Venue
Clinical Cases in Mineral and Bone Metabolism
Publisher
Edikta s.r.l.
Published
2015
Volume
12
Issue
1
Pages
31-3
ISSN
1724-8914 (ISSN-L)
DOI
10.11138/ccmbm/2015.12.1.031
PMC
PMC4469223
OpenAlex
W2395467752
Cited by
126
References
0
Citations by year
2026: 6 · 2025: 16 · 2024: 18 · 2023: 15 · 2022: 9 · 2021: 15 · 2020: 10 · 2019: 6 · 2018: 13 · 2017: 5 · 2016: 11 · 2015: 2
FWCI
7.96
Type
journal article
Language
en
Open access
Locations
  • Clinical cases in mineral and bone metabolism (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
Keywords
hyaluronic acid, osteoarthritis, viscosupplementation, knee osteoarthritis, intra-articular injection, cartilage degeneration, matrix metalloproteinases, pro-inflammatory mediators, joint lubrication, long-term treatment

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