The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
A Hybrid Experimental-Computational Modeling Framework for Cardiovascular Device Testing
Abstract
Significant advances in biomedical science often leverage powerful computational and experimental modeling platforms. We present a framework named physiology simulation coupled experiment (“PSCOPE”) that can capitalize on the strengths of both types of platforms in a single hybrid model. PSCOPE uses an iterative method to couple an in vitro mock circuit to a lumped-parameter numerical simulation of physiology, obtaining closed-loop feedback between the two. We first compared the results of Fontan graft obstruction scenarios modeled using both PSCOPE and an established multiscale computational fluid dynamics method; the normalized root-mean-square error values of important physiologic parameters were between 0.1% and 2.1%, confirming the fidelity of the PSCOPE framework. Next, we demonstrate an example application of PSCOPE to model a scenario beyond the current capabilities of multiscale computational methods—the implantation of a Jarvik 2000 blood pump for cavopulmonary support in the single-ventricle circulation; we found that the commercial Jarvik 2000 controller can be modified to produce a suitable rotor speed for augmenting cardiac output by approximately 20% while maintaining blood pressures within safe ranges. The unified modeling framework enables a testing environment which simultaneously operates a medical device and performs computational simulations of the resulting physiology, providing a tool for physically testing medical devices with simulated physiologic feedback.
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“In addition to systems biology, computational models are also becoming essential tools in biomedical applications such as drug discovery [61], pharmacokinetics [62], and medical devices [63].”
From Adapting modeling and simulation credibility standards to computational systems biology (2023) · cites this paper as [63]
Citations
Cites
Analog studies of the human systemic arterial tree
Westerhof, N., Bosman, F., De Vries, C. J., & Noordergraaf, A. (1969) · Journal of Biomechanics · doi:10.1016/0021-9290(69)90024-4 · Cited by 684
SimVascular: An Open Source Pipeline for Cardiovascular Simulation
Updegrove, A. R., Wilson, N. M., Merkow, J., Lan, H., Marsden, A. L., & Shadden, S. C. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1762-8 · Cited by 657
Clinical Outcome of 193 Extracardiac Fontan Patients
Giannico, S., Hammad, F. K., Amodeo, A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.12.065 · Cited by 199
Right-Sided Univentricular Cardiac Assistance in a Failing Fontan Circulation
Prêtre, R., Häussler, A., Béttex, D., & Genoni, M. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.03.003 · Cited by 159
Characterization of an Adult Mock Circulation for Testing Cardiac Support Devices
Pantalos, G. M., Koenig, S. C., Gillars, K. J., Giridharan, G. A., & Ewert, D. L. (2004) · ASAIO Journal · doi:10.1097/01.mat.0000104818.70726.e6 · Cited by 142
Steinman, D. A., Hoi, Y., Fahy, P., Morris, L. G., Walsh, M. T., Aristokleous, N., Anayiotos, A. S., Papaharilaou, Y., Arzani, A., Shadden, S. C., et al. (2013) · Journal of Biomechanical Engineering · doi:10.1115/1.4023382 · Cited by 141
Computational Fluid Dynamics as a Development Tool for Rotary Blood Pumps
Burgreen, G. W., Antaki, J. F., Wu, Z. J., & Holmes, A. J. (2001) · Artificial Organs · doi:10.1046/j.1525-1594.2001.025005336.x · Cited by 131
Optimal conduit size for extracardiac Fontan operation✩
Alexi-Meskishvili, V. V., Ovroutski, S., Ewert, P., Dähnert, I., Berger, F. F., Lange, P., & Hetzer, R. (2000) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(00)00593-5 · Cited by 108
A Novel Interface for Hybrid Mock Circulations to Evaluate Ventricular Assist Devices
Ochsner, G., Amacher, R., Amstutz, A., Plass, A., Daners, M. S., Tevaearai, H. T., Vandenberghe, S., Wilhelm, M. J., & Guzzella, L. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2230000 · Cited by 95
In Vitro Validation of Finite Element Analysis of Blood Flow in Deformable Models
Kung, E. O., Les, A. S., Figueroa, C. A., Medina, F. R., Arcaute, K., Wicker, R. B., McConnell, M. V., & Taylor, C. A. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0284-7 · Cited by 95
Self-citation
Cited by
Adapting modeling and simulation credibility standards to computational systems biology
Tatka, L. T., Smith, L. P., Hellerstein, J. L., & Sauro, H. M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04290-5 · Cited by 27
Metadata
- Authors
- Kung, E., Farahmand, M., & Gupta, A.
- Affiliations
- Clemson University (US)
- Corresponding author
- Kung, Ethan
- Venue
- Journal of Biomechanical Engineering
- Publisher
- ASME International
- Published
- 2019-03-27
- Volume
- 141
- Issue
- 5
- ISSN
- 0148-0731 (ISSN-L)
- 1528-8951
- OpenAlex
- W2911676207
- Cited by
- 28
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomechanical Engineering (publishedVersion)
- PubMed (publishedVersion)
- TigerPrints (Clemson University) (submittedVersion)
- Funders
- American Heart Association (16SDG29850012)
- National Science Foundation (1749017)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- closed-loop feedback, rotor speed control
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
