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Indocyanine-green-embedded PEBBLEs as a contrast agent for photoacoustic imaging
Open accessAbstract
Nanoparticles 100 nm in diameter containing indocyanine green (ICG) have been developed as a contrast agent for photoacoustic (PA) imaging based on (photonic explorers for biomedical use by biologically localized embedding PEBBLE) technology using organically modified silicate (ormosil) as a matrix. ICG is an FDA-approved dye with strong optical absorption in the near-infrared (NIR) region, where light can penetrate deepest into biological tissue. A photoacoustic imaging system was used to study image contrast as a function of PEBBLE concentration in phantom objects. ICG-embedded ormosil PEBBLEs showed improved stability in aqueous solution compared with free ICG dye. The particles were conjugated with HER-2 antibody for breast cancer and prostate cancer cell targeting. Initial in vitro characterization shows high contrast and high efficiency for binding to prostate cancer cells. ICG can also be used as a photosensitizer (generating toxic oxygen by illumination) for photodynamic therapy. We have measured the photosensitization capability of ICG-embedded ormosil nanoparticles. This feature can be utilized to combine detection and therapeutic functions in a single agent.
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Cited by
Krohn, K. A., Link, J. M., & Mason, R. P. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.045914 · Cited by 506
Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice
Zerda, A. D. L., Liu, Z., Bodapati, S., Teed, R., Vaithilingam, S., Khuri-Yakub, B. T., Chen, X., Dai, H., & Gambhir, S. S. (2010) · Nano Letters · doi:10.1021/nl100890d · Cited by 396
Kuo, W.-S., Chang, Y.-T., Cho, K.-C., Chiu, K.-C., Lien, C.-H., Yeh, C.-S., & Chen, S.-J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.035 · Cited by 305
Advances in Diagnostic and Intraoperative Molecular Imaging of Pancreatic Cancer
Tummers, W. S., Willmann, J. K., Bonsing, B. A., Vahrmeijer, A. L., Gambhir, S. S., & Swijnenburg, R.-J. (2018) · Pancreas · doi:10.1097/mpa.0000000000001075 · Cited by 50
Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm
Miranda, D., Huang, H., Kang, H., Zhan, Y., Wang, D., Zhou, Y., Geng, J., Kilian, H. I., Stiles, W., Razi, A., et al. (2019) · Theranostics · doi:10.7150/thno.28376 · Cited by 48
Metadata
- Authors
- Kim, G., Huang, S.-W., Day, K. C., O’Donnell, M., Agayan, R. R., Day, M. A., Kopelman, R., & Ashkenazi, S.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2007
- Volume
- 12
- Issue
- 4
- Pages
- 044020
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2036926656
- Cited by
- 196
- References
- 0
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kim, G., Huang, S.-W., Day, K. C., O’Donnell, M., Agayan, R. R., Day, M. A., Kopelman, R., & Ashkenazi, S. (2007). Indocyanine-green-embedded PEBBLEs as a contrast agent for photoacoustic imaging. Journal of Biomedical Optics. https://doi.org/10.1117/1.2771530
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