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Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation
Open accessAbstract
The risk of local recurrence for breast cancers is strongly correlated with the presence of a tumor within 1 to 2 mm of the surgical margin on the excised specimen. Previous experimental and theoretical results suggest that spatially offset Raman spectroscopy (SORS) holds much promise for intraoperative margin analysis. Based on simulation predictions for signal-to-noise ratio differences among varying spatial offsets, a SORS probe with multiple source-detector offsets was designed and tested. It was then employed to acquire spectra from 35 frozen-thawed breast tissue samples in vitro. Spectra from each detector ring were averaged to create a composite spectrum with biochemical information covering the entire range from the tissue surface to ∼2 mm below the surface, and a probabilistic classification scheme was used to classify these composite spectra as "negative" or "positive" margins. This discrimination was performed with 95% sensitivity and 100% specificity, or with 100% positive predictive value and 94% negative predictive value.
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Cited by
Using Raman spectroscopy to characterize biological materials
Butler, H. J., Ashton, L., Bird, B., Cinque, G., Curtis, K., Dorney, J., Esmonde-White, K., Fullwood, N. J., Gardner, B., Martin-Hirsch, P. L., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.036 · Cited by 1,309
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging
Lane, L. A., Qian, X., & Nie, S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00265 · Cited by 873
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Wang, Y. “., Reder, N. P., Kang, S., Glaser, A. K., Yang, Q., Wall, M. A., Javid, S. H., Dintzis, S. M., & Liu, J. T. C. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0709 · Cited by 104
Lloyd, G. R., Orr, L. E., Christie-Brown, J., McCarthy, K., Rose, S., Thomas, M., & Stone, N. (2013) · The Analyst · doi:10.1039/c2an36579k · Cited by 83
Metadata
- Authors
- Keller, M. D., Vargis, E., de Matos Granja, N., Wilson, R. H., Mycek, M.-A., Kelley, M. C., & Mahadevan-Jansen, A.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2011
- Volume
- 16
- Issue
- 7
- Pages
- 077006
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2117854023
- Cited by
- 194
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Keller, M. D., Vargis, E., de Matos Granja, N., Wilson, R. H., Mycek, M.-A., Kelley, M. C., & Mahadevan-Jansen, A. (2011). Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. Journal of Biomedical Optics. https://doi.org/10.1117/1.3600708
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