The DOI matches its Crossref record; 118 of the 127 references it cites were found in a registry or an index.
Optical properties of human skin
Open accessAbstract
A survey of the literature is presented that provides an analysis of the optical properties of human skin, with particular regard to their applications in medicine. Included is a description of the primary interactions of light with skin and how these are commonly estimated using radiative transfer theory (RTT). This is followed by analysis of measured RTT coefficients available in the literature. Orders of magnitude differences are found within published absorption and reduced-scattering coefficients. Causes for these discrepancies are discussed in detail, including contrasts between data acquired in vitro and in vivo. An analysis of the phase functions applied in skin optics, along with the remaining optical coefficients (anisotropy factors and refractive indices) is also included. The survey concludes that further work in the field is necessary to establish a definitive range of realistic coefficients for clinically normal skin.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“likely because darker skin contains more melanin which absorbs more green light than lighter skin.”
From Investigating sources of inaccuracy in wearable optical heart rate sensors (2020) · cites this paper as [28]
In the citing paper
“previous research demonstrated that inaccurate PPG HR measurements occur up to 15% more frequently in dark skin as compared to light skin”
From Investigating sources of inaccuracy in wearable optical heart rate sensors (2020) · cites this paper as [28]
Citations
Cites
MCML—Monte Carlo modeling of light transport in multi-layered tissues
Wang, L. V., Jacques, S. L., & Zheng, L. (1995) · Computer Methods and Programs in Biomedicine · doi:10.1016/0169-2607(95)01640-f · Cited by 3,330
Diffuse radiation in the Galaxy
Henyey, L. C., & Greenstein, J. L. (1941) · The Astrophysical Journal · doi:10.1086/144246 · Cited by 2,971
A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
Anderson, R. R., & Parrish, J. A. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479191 · Cited by 2,456
Bashkatov, A. N., Genina, E. A., Kochubey, V. I., & Tuchin, V. V. (2005) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/38/15/004 · Cited by 1,720
Optical-Thermal Response of Laser-Irradiated Tissue
Welch, A. J., & van Gemert, M. J. C. (2011) · Springer eBooks · doi:10.1007/978-90-481-8831-4 · Cited by 1,455
In Vivo Confocal Scanning Laser Microscopy of Human Skin: Melanin Provides Strong Contrast
Rajadhyaksha, M. M., Grossman, M. C., Esterowitz, D., Webb, R. H., & Anderson, R. R. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12606215 · Cited by 1,090
Lasers in Surgery and Medicine
American Society for Laser Medicine and Surgery (2006) · Lasers in Surgery and Medicine · doi:10.1002/(issn)1096-9101 · Cited by 1,088
van Gemert, M. J. C., Jacques, S. L., Sterenborg, H. J. C. M., & Star, W. (1989) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.42108 · Cited by 807
Optical-Thermal Response of Laser-Irradiated Tissue
Welch, A. J., & van Gemert, M. J. C. (1995) · Springer eBooks · doi:10.1007/978-1-4757-6092-7 · Cited by 705
Cited by
Sorted by citations
Items 401–472 of 472
Noninvasive Quantitative Tissue Biopsy Using Precise Optical Phantoms
Vijayaragavan, V., & Sujatha, N. (2019) · Springer eBooks · doi:10.1007/978-981-13-1477-3_4
Okawa, S., Hirasawa, T., Tsujita, K., Kushibiki, T., & Ishihara, M. (2019) · Nippon Laser Igakkaishi · doi:10.2530/jslsm.jslsm-40_0033
Motion artefact minimisation from a photoplethysmography based non-invasive sensor
Yuan, H. (2017) · University of Limerick Institutional Repository (University of Limerick) · doi:10.34961/3746
The effect of ultraviolet on direct current potentials of the human skin
Лазарев, А. О. (2017) · Vestnik dermatologii i venerologii · doi:10.25208/0042-4609-2017-93-1-31-37
Madani, S. Z. M. (2020) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-moafi-madani-seyedeh-zahra-2020
Non-ablative photorejuvenation of lips by a 660-nm diode laser: two-case report
Alnaggar, A., & Mahmoud, M. (2020) · Lasers in Dental Science · doi:10.1007/s41547-020-00098-4
A Novel Methodology for Assessing Children's Heart Rate and Stress
Yao, Y. (2019) · TSpace (University of Toronto)
The biophysics of photothermal treatments with lasers and intense pulsed light systems
Murphy, M. (2021) · Journal of Aesthetic Nursing · doi:10.12968/joan.2021.10.sup2.40
Determining optical properties of skin ex-vivo: An inverse solutionPreprint
Sirpal, P. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2109.02459
Spatial mapping of the tumor immune microenvironment
Wu, Y.-C., Pagacz, J., Emery, S. C., Kron, S. J., & Lee, S. S.-Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90949-5.00009-7
An Optical Microneedle for Localized Light Therapy on Melanoma Cells
Wu, X., Park, J., & Kim, B. (2022) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems51670.2022.9699552
Investigating Sources of Inaccuracy in Wearable Optical Heart Rate Sensors (Preprint)Preprint
Bent, B., Goldstein, B. A., Kibbe, W. A., & Dunn, J. (2020) · doi:10.2196/preprints.18126
Sweetnich, S. R., & Jacques, D. R. (2019) · IGI Global eBooks · doi:10.4018/978-1-5225-8365-3.ch009
Knobler, R. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733069333.793544985
Deciphering the broadband absorption of eumelanin in solutionPreprint
Izgorodina, E. I., Singh, A., Mason, T. G., & Freeman, B. D. (2022) · Research Square · doi:10.21203/rs.3.rs-2133327/v1 · Cited by 1
Deciphering the broadband absorption of eumelanin in solution phasePreprint
Singh, A., Mason, T. G., Freeman, B. D., & Izgorodina, E. I. (2022) · Research Square · doi:10.21203/rs.3.rs-2296450/v1
Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography
Saratxaga, C. L., Asumendi, A., Gardeazábal, J., Izu, R., Sanchez, A., Cancho-Galan, G., Morales, M., Lage, S., Boyano, M. D., Conde, O. M., et al. (2023) · Life · doi:10.3390/life13030625
Oxygen Saturation Monitor Model Design for Freediving Implementation
Razzhivina, K. R., Kamarchuk, A. V., & Shiryaev, D. S. (2023) · Reviews on advanced materials and technologies · doi:10.17586/2687-0568-2023-5-1-33-38
Optical characterization of highly turbid samples in the visible and near infrared spectra
da Cruz, L. B. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2023.tde-27062023-140611
Low-Level Light Therapy with LEDs
Green, C., & Borden, G. (2023) · Springer eBooks · doi:10.1007/978-3-031-36266-8_9
Measuring Refractive Index of Fingerprints
Fenrich, R. W., & Fenrich, R. K. (2023) · IEEE Research and Applications of Photonics in Defense Conference (RAPID) · doi:10.1109/rapid54473.2023.10264764
Kojima, K., Rajagopalan, U. M., Yamada, J., & Kono, T. (2024) · Photonics in Dermatology and Plastic Surgery · doi:10.1117/12.3002738
Gao, Y., Feng, T., Zuo, C., & Ma, H. (2024) · Journal of Physics Conference Series · doi:10.1088/1742-6596/2822/1/012036
Lefebvre, A., Hanamoto, W., Park, J., Dewalle, A. S., Grolez, G. P., Delhem, N., Mortier, L., & Kim, B. (2024) · IEEE CPMT Symposium Japan (ICSJ) · doi:10.1109/icsj62869.2024.10804694
Upper and Lower Respiratory Conditions
Petty, M. C. (2025) · Wiley eBooks · doi:10.1002/9781394205356.ch12
General Principles of Laser Therapy
Miller, L. A. (2025) · Wiley eBooks · doi:10.1002/9781394205356.ch4
Rahaman, N. S. A., Jumadi, N. A., Huong, A. K. C., Mahmud, W. M. H. W., & Ali, J. (2024) · Journal of Advanced Research in Applied Sciences and Engineering Technology · doi:10.37934/araset.55.1.177190
Photodynamic therapy for infection treatment through novel laminar flow fibre optics
Jolly, A. K., Avellar, M. L. D., & Hammond, R. (2025) · Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases · doi:10.1117/12.3043225
Optical Microscopic Techniques for Evaluation of Dermal Drug Absorption from Topical Products
Tu, D., Khoo, T. C., Wei, Y., Luna, S. K., Kuzma, B. A., & Evans, C. L. (2024) · AAPS introductions in the pharmaceutical sciences · doi:10.1007/978-3-031-80525-7_4
Laser Acupuncture for Chronic Pain
Uzun, E., Tekeoğlu, İ., & Şahin, M. Z. (2025) · Sakarya Medical Journal · doi:10.31832/smj.1541981
Changes in Laser Wavelengths Entering the Skin Due to Changes in Refractive Indices
Murphy, M. J., & MacKinnon, A. (2025) · Journal of Dermatology Research · doi:10.46889/jdr.2025.6208
Chenfan, 沈. S., Jianmin, 杨. Y., Wei, 刘. L., Mengdi, 马. M., Mengjiao, 朱. Z., Xiaomei, 黄. H., Qiao, 朱. Z., Zili, 曹. C., Weihao, 林. L., & Min, 徐. X. (2025) · Chinese Journal of Lasers · doi:10.3788/cjl241457
Samanta, P., Mizaikoff, B., Mishra, S., & Tiwari, U. K. (2025) · Journal of Optics · doi:10.1007/s12596-025-02846-w
In Vivo Clinical Evaluation of Human Intestinal Tissue Viability Using a Spectroscopic Method
Karaçaylı, D., Dandin, Ö., Örmeci, M., Elpek, G. Ö., Gülkesen, K. H., Kahya, B., & Murat Canpolat, A. (2025) · Journal of Surgical Research · doi:10.1016/j.jss.2025.06.042
Visual appearance of blood vessels: a phantom study
Wagner, M., Hevisov, D., Konrad, C., Schmidt, H., Foschum, F., & Kienle, A. (2025) · Biomedical Optics Express · doi:10.1364/boe.579246
Kovačević, M. S., Marković, V., Tosi, D., Blanc, W., Kovačević, I., & Kuzmanović, L. (2025) · Optik · doi:10.1016/j.ijleo.2025.172622
Stacked VCSEL Integration in PPG Sensor for Enhanced Optical Signal Collection
Li, Z., & Tang, Q. (2025) · IEEE Optoelectronics Global Conference (OGC) · doi:10.1109/ogc66041.2025.11262124
Camera-based physiological measurement: fundamentals and methodologies
Slapničar, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26586-0.00002-8
Energy-Based Devices (EBD) and Melanin
Lee, J. H., Jung, H., Choi, S., Kim, H. M., Kim, G. B., & Park, H. J. (2025) · Springer eBooks · doi:10.1007/978-981-95-0233-2_7
Simulation Study on Parameter Optimization of Laser Acupuncture Based on a Human Acupoint Skin Model
Zhao, Z., Han, S., Xie, S., Xue, W., Dong, H., Xue, R., & Li, P. (2026) · Photonics · doi:10.3390/photonics13010085
In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort
Amezcua-López, E. E., Corral-Martínez, L. F., Trujillo-Schiaffino, G., Salas-Peimbert, D. P., Anguiano-Morales, M., & Ramírez-Quintana, J. A. (2026) · Applied Sciences · doi:10.3390/app16021021
Marasco, E., Janga, B., Gali, G., & Ramachandra, R. (2026) · IEEE Transactions on Biometrics Behavior and Identity Science · doi:10.1109/tbiom.2026.3657642
Effects of Near-Infrared Photobiomodulation on Local Skin Blood Flow in Healthy Subjects
Riaz, M., Bösch, P. C., Åm, M. K., Ellingsen, R., Hjelme, D. R., Carlsen, S. M., & Christiansen, S. C. (2026) · Photonics · doi:10.3390/photonics13020119
Gao, J., San, I. W., Luo, X., Chen, Z., Tan, T., & Sun, Y. (2025) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm66473.2025.11356870
García, E. T., Torres-Velázquez, H., Zerón, H. M., Romero, M., & Torres-García, G. (2026) · Lasers in Surgery and Medicine · doi:10.1002/lsm.70105
Skin Optical Detection Methods
Peiponen, K. ‐., & Asamoah, B. O. (2026) · Springer eBooks · doi:10.1007/978-3-032-14644-1_10
Al-Ibadi, Z. (2026) · International Journal of Physics and Applications · doi:10.33545/26647575.2026.v8.i1b.247
Li, Y., Li, G., Wang, Y., Liu, X., & Cai, F. (2026) · Measurement · doi:10.1016/j.measurement.2026.121000
Kang, S. (2026) · The Journal of the Acoustical Society of America · doi:10.1121/10.0043328
Kang, S. (2026) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ae6347
Stable and Low‐cost Multilayer Tissue‐mimicking Phantom for Optical and Acoustic Measurements
Boštogaitė, E., Rey, A. B. A., Rudmann, L., & Stieglitz, T. (2026) · Advanced Sensor Research · doi:10.1002/adsr.70158
Multilayer silicone phantom for skin tissue optical representation in hyperspectral applications
Lacagnina, E., Bossi, A., Pacheco, A., Locatelli, M., Nieri, G., Oggionni, L., Ouairem, M., Pifferi, A., & Saccomandi, P. (2026) · Tissue Optics and Photonics · doi:10.1117/12.3098694
Monte Carlo modeling of age-dependent skin appearance with subsurface inclusions
Irbe, I., Rubīns, U., & Majaron, B. (2026) · Tissue Optics and Photonics · doi:10.1117/12.3099811
Keum, J., Zheng, H., Zhu, G., Kang, G., Kim, H., Hwang, J., Shin, D., Lee, J., Kim, Y., & Kim, W. (2026) · Applied Thermal Engineering · doi:10.1016/j.applthermaleng.2026.131946
Sung, B., Jang, S., Jang, E., An, S., Lee, J., Lee, J.-H., & Lee, J. (2026) · Journal of Information Display · doi:10.1007/s44469-026-00017-6
Guiotto, A., Alghamdi, M., Hickerson, R., Conneely, M., Choudhary, H., Brieva, P. M., Lim, Y., Pecorelli, A., & Valacchi, G. (2026) · Antioxidants · doi:10.3390/antiox15091072
Visible-light-based modulation of bacterial quorum sensing with photoswitchable signal molecules
Luotonen, O. I. V., Puolakka, J., Vannas, J., Priimägi, A., Anaya‐Plaza, E., Mangayil, R. K., & Kostiainen, M. A. (2026) · Nanoscale · doi:10.1039/d6nr02698b
Ranganathan, C., Prince, S., Saba, A., & Chandrasekaran, A. (2026) · Journal of Biophotonics · doi:10.1002/jbio.70368
Photobiomodulation: multifaceted therapeutic effects on disorders in the central nervous system
Xiong, W., Su, Y., Chen, H., Verkhratsky, A., & Yi, C. (2026) · Clinical Science · doi:10.1042/cs20261472
Photoacoustic Microscopy: Technological Advances, Biomedical Applications, and Future Perspectives
Zhang, X., Yin, H., Li, Z., Song, K., Liu, N., & Liu, K. (2026) · Journal of Biophotonics · doi:10.1002/jbio.70375
From Coral Color to Tissue Heating: How Host Pigments Redirect Light Within the TissuePreprint
Murthy, S., Bollati, E., Salih, A., & Kühl, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.20.760344
Latitude, cities and health: What do we know and need to do about daylight?
Amorim, C. N. D., Hobday, R. A., Sokol, N., Dervishaj, A., Volf, C., Kenny, P., Foster, R. G., & Norton, B. (2026) · City and Environment Interactions · doi:10.1016/j.cacint.2026.100519
Metadata
- Authors
- Lister, T., Wright, P. A., & Chappell, P. H.
- Affiliations
- Salisbury District Hospital (GB)
- University of Southampton (GB)
- ORCID
- Chappell, Paul H.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2012-09-24
- Volume
- 17
- Issue
- 9
- Pages
- 1-15
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- OpenAlex
- W2020476250
- Cited by
- 467
- References
- 127
- Citations by year
- 2026: 26 · 2025: 37 · 2024: 46 · 2023: 40 · 2022: 37 · 2021: 51 · 2020: 38 · 2019: 35 · 2018: 33 · 2017: 36 · 2016: 21 · 2015: 32 · 2014: 18 · 2013: 12 · 2012: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Optics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Keywords
- human skin, optical properties, radiative transfer theory, optical absorption coefficient, reduced scattering coefficient, phase function, anisotropy parameter, refractive index
- MeSH terms
- Light, Models, Biological, Refractometry, Scattering, Radiation, Skin Physiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review