The DOI matches its Crossref record.
Dosimetry considerations in phototherapy
Abstract
Dosimetry in phototherapy involves a determination of the energy absorbed per unit mass of tissue, corrected for the quantum yield in a photochemical reaction. The dose rate in photochemotherapy of cancer with hematoporphyrin derivative and visible light is related to the extinction coefficient, quantum yield for singlet oxygen production, concentration of sensitizer and energy flux density at depth. Data or methods of determining these quantities are presented. Calculations have been performed for the energy flux density at depth, as a function of the total attenuation coefficient and ratio of scattering coefficient to total attenuation coefficient, for isotropic scattering in slab geometry. For small absorption, these depth dose curves exhibit a maximum within the tissue followed by an exponential decrease.
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“Nevertheless, significant disadvantages of ALA-PDT include pain associated with treatment [83], limited depth of tumor penetration [84,85], as well as individual variations among patients that affect ALA absorption and pharmacokinetics that influence effective ALA concentrations in the treated area [86].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [85]
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Cited by
Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265
Metadata
- Authors
- Profio, A. E., & Doiron, D. R.
- Affiliations
- University of Southern California (US)
- Venue
- Medical Physics
- Publisher
- Wiley
- Published
- 1981-03
- Volume
- 8
- Issue
- 2
- Pages
- 190-196
- ISSN
- 0094-2405 (ISSN-L)
- 2473-4209
- OpenAlex
- W2157945256
- Cited by
- 72
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2014: 1
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Physics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (RAD5 R01 CA‐25582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- photochemotherapy, hematoporphyrin derivative, quantum yield, singlet oxygen, extinction coefficient, depth dose curves, light attenuation coefficient, scattering coefficient, isotropic scattering, slab geometry, tissue absorption
- MeSH terms
- Fluorescence, Hematoporphyrins, Humans, Neoplasms, Photochemotherapy, Phototherapy, Radiation Dosage, Technology, Radiologic
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
