The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
No Effect of Heavy Resistance Training and Creatine Supplementation on Blood Lipids
Abstract
In order to examine the effects of heavy resistance training and the influence of creatine supplementation on nonperformance measures of health status, 19 healthy resistance-trained men were matched and then randomly assigned in a double-blind fashion to either a creatine (n = 10) or placebo (n = 9) group. Periodized heavy resistance training was performed 3—4 times per week for 12 weeks. During the first week of training, creatine subjects consumed 25 g creatine monohydrate per day, while the placebo group ingested an equal number of placebo capsules. Five grams of supplement per day was consumed for the remainder of the study. Body composition, fasting serum creatinine, lipo-proteins and triglycerides, and reported changes in body function were determined prior to and after 12 weeks of training and supplementation. After training, significant increases in body mass and fat-free mass were greater in creatine (5.2 and 4.3 kg, respectively) than placebo (3.0 and 2.1 kg. respectively) subjects. There was no change in percent body fat. Dietary energy and macronutrient distribution was not significantly different during Weeks 1 and 12. Serum creatinine was significantly elevated in creatine subjects after 1(11.6%) and 12 weeks (13.8%); however, values were within normal limits for healthy men. There were no effects of training or supplementation on serum total cholesterol, HDL-cholesterol, LDL-cholesterol. or triglycerides. In healthy men, a 12-week heavy resistance training program, with or without creatine supplementation, did not significantly influence serum lipid profiles, subjective reports of body functioning, or serum creatinine concentrations.
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“while a few human studies have reported improvements in lipid profiles with CrM [160,161], the majority have found no significant effects most have found no significant effect of CrM on the lipid profile [162–164].”
From Creatine monohydrate supplementation for older adults and clinical populations (2025) · cites this paper as [164]
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Citations
Cites
Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
Harris, R. C., Söderlund, K., & Hultman, E. (1992) · Clinical Science · doi:10.1042/cs0830367 · Cited by 1,168
Effects of creatine supplementation on body composition, strength, and sprint performance
KREIDER, R. B., FERREIRA, M., WILSON, M., GRINDSTAFF, P., PLISK, S., REINARDY, J., CANTLER, E., & ALMADA, A. L. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199801000-00011 · Cited by 430
Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training
VOLEK, J. S., DUNCAN, N. D., MAZZETTI, S. A., STARON, R. S., PUTUKIAN, M., G??MEZ, A. L., PEARSON, D. R., FINK, W. J., & KRAEMER, W. J. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199908000-00011 · Cited by 366
Self-citationMuscle hypertrophy and fast fiber type conversions in heavy resistance-trained women.
Staron, R. S., Malicky, E. S., Leonardi, M. J., Falkel, J. E., Hagerman, F. C., & Dudley, G. A. (1990) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00572189 · Cited by 328
Creatine Supplementation Enhances Muscular Performance During High-Intensity Resistance Exercise
VOLEK, J. S., KRAEMER, W. J., BUSH, J. A., BOETES, M., INCLEDON, T., CLARK, K. L., & LYNCH, J. M. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00189-2 · Cited by 219
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Cited by
Effect of creatine supplementation on body composition and performance: a meta-analysis
Branch, J. D. (2003) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.13.2.198 · Cited by 309
Nissen, S. L., & Sharp, R. L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00755.2002 · Cited by 258
Creatine supplementation combined with resistance training in older men
CHRUSCH, M. J., CHILIBECK, P. D., CHAD, K. E., SHAWN DAVISON, K., & BURKE, D. G. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200112000-00021 · Cited by 233
Tambalis, K., Panagiotakos, D. B., Kavouras, S. A., & Sidossis, L. S. (2009) · Angiology · doi:10.1177/0003319708324927 · Cited by 224
Effects of oral creatine and resistance training on myosin heavy chain expression
WILLOUGHBY, D. S., & ROSENE, J. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200110000-00010 · Cited by 209
Kreider, R. B., Melton, C., Rasmussen, C. J., Greenwood, M., Lancaster, S., Cantler, E. C., Milnor, P., & Almada, A. L. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1022469320296 · Cited by 181
Pharmacokinetics of the Dietary Supplement Creatine
Persky, A. M., Brazeau, G. A., & Hochhaus, G. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342060-00005 · Cited by 132
Kraemer, W. J., & Volek, J. S. (1999) · Clinics in Sports Medicine · doi:10.1016/s0278-5919(05)70174-5 · Cited by 130
Volek, J. S., Ratamess, N. A., Rubin, M. R., G�mez, A. L., French, D. N., McGuigan, M. M., Scheett, T. P., Sharman, M. J., H�kkinen, K., & Kraemer, W. J. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-1031-z · Cited by 107
“In order to assess potential side effects and subjective changes in body function to the supplementation regimen a questionnaire used in prior creatine studies by our laboratory (Volek et al. 2000, 2001) was provided to subjects at the end of the study.”
MethodResultSelf-citationEffect of Creatine Ingestion after Exercise on Muscle Thickness in Males and Females
CHILIBECK, P. D., STRIDE, D., FARTHING, J. P., & BURKE, D. G. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000142301.70419.c6 · Cited by 89
Gualano, B., Ugrinowitsch, C., Novaes, R. B., Artioli, G. G., Shimizu, M. H., Seguro, A. C., Harris, R. C., & Lancha, A. H. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0669-3 · Cited by 88
Mayhew, D. L., Mayhew, J. L., & Ware, J. S. (2002) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.12.4.453 · Cited by 66
Safety of Creatine Supplementation
Persky, A. M., & Rawson, E. S. (2007) · Subcellular Biochemistry · doi:10.1007/978-1-4020-6486-9_14 · Cited by 60
Cornelissen, V., Defoor, J., Stevens, A., Schepers, D., Hespel, P., Decramer, M., Mortelmans, L., Dobbels, F., Vanhaecke, J., Fagard, R., et al. (2010) · Clinical Rehabilitation · doi:10.1177/0269215510367995 · Cited by 51
Creatine monohydrate supplementation for older adults and clinical populations
Candow, D. G., Ostojic, S. M., Chilibeck, P. D., Longobardi, I., Gualano, B., Tarnopolsky, M. A., Wallimann, T., Moriarty, T., Kreider, R. B., Forbes, S. C., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2534130 · Cited by 43
(2004) · PubMed Central · Cited by 14
Metadata
- Authors
- Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gómez, A. L., & Kraemer, W. J.
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2000-06
- Volume
- 10
- Issue
- 2
- Pages
- 144-156
- ISSN
- 1526-484X
- 1543-2742
- Cited by
- 31
- References
- 5
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