Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
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Seeded tissue densities can be estimated from the volume of 1 million primary human hepatocytes with an average cellular volume of 2.3 × 10^3 μm^3 resulting in 2.3 μL total cell volume, corresponding to an upper limit on the cell density of 4.3 × 10^8 cells mL-1 located within the MPS acinus model volume of 20 μL (excluding the synthetic vasculature channels).
“Seeded tissue densities can be estimated from the volume of 1 million primary human hepatocytes with an average cellular volume of 2.3 × 10 3 μm 3 [39] resulting in 2.3 μL total cell volume.This corresponds to an upper limit on the cell density of 4.3 × 10 8 cells mL -1 located within the MPS acinus model volume of 20 μL (excluding the synthetic vasculature channels).”
From 3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation (2023) · cites this paper as [39]
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De Bruyn, T., Ufuk, A., Cantrill, C., Kosa, R. E., Bi, Y.-A., Niosi, M., Modi, S., Rodrigues, A. D., Tremaine, L. M., Varma, M. V. S., et al. (2018) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.081315 · Cited by 53 · see citing works
Wesseler, M. F., Taebnia, N., Harrison, S., Youhanna, S., Preiss, L. C., Kemas, A. M., Vegvari, A., Mokry, J., Sullivan, G. J., Lauschke, V. M., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.09.022 · Cited by 39 · see citing works
- Authors
- Yoshikado, T., Toshimoto, K., Nakada, T., Ikejiri, K., Kusuhara, H., Maeda, K., & Sugiyama, Y.
- Venue
- Drug Metabolism and Disposition
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 45
- Issue
- 7
- Pages
- 779-789
- ISSN
- 0090-9556
- Cited by
- 51
- References
- 0
- Language
- en
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