Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
Westlind-Johnsson, Anna, Malmebo, Sarah, Johansson, Anna, Otter, Charlotta, Andersson, Tommy B., Johansson, Inger, Edwards, Robert J., Boobis, Alan R. +1 more·2003·Drug Metabolism and Disposition
Cited by (256)
Items 101–200 of 256
- Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliineJia Ning, Lu Chen, Marije Strikwold, Jochem Louisse, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens · 2019 · Archives of Toxicology
- Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populationsMarkus Schirmer, Mohammad Reza Toliat, Michael Haberl, Anita Suk, Landry K. Kamdem, Kathrin Klein, Jürgen Brockmöller, Peter Nürnberg, Ulrich M. Zanger, Leszek Wojnowski · 2006 · Pharmacogenetics and Genomics
- Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonistShin Takusagawa, Kanako Yajima, Aiji Miyashita, Shotaro Uehara, Takafumi Iwatsubo, Takashi Usui · 2012 · Xenobiotica
- CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteersTsuyoshi Fukuda, S Onishi, Shuichi Fukuen, Yuka Ikenaga, Masako Ohno, K Hoshino, Katsumi Matsumoto, A Maihara, Kouichi Momiyama, T Ito et al. · 2003 · The Pharmacogenomics Journal
- CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA DecayFlorent Busi, Thierry Cresteil · 2005 · Molecular Pharmacology
- The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5Mei‐Hui Hsu, Üzen Savas, Eric F. Johnson · 2017 · Molecular Pharmacology
- In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamilyAmégnona Agbonon, Kwashie Eklu‐Gadegbeku, Kodjo A. Aklikokou, Messanvi Gbéassor, Koffi Akpagana, Teresa W. Tam, John Thor Arnason, Brian C. Foster · 2010 · Journal of Ethnopharmacology
- Expression, Activity and Regulation of CYP3A in Human and Rodent BrainCindy L.A. Woodland, T. T. Huang, Elzbieta A Gryz, Reina Bendayan, J. Paul Fawcett · 2008 · Drug Metabolism Reviews
- The missing linkage: what pharmacogenetic associations are left to find inCYP3A?Minoli A. Perera · 2009 · Expert Opinion on Drug Metabolism & Toxicology
- Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticidesFranca M. Buratti, Claudia Leoni, Emanuela Testai · 2006 · Toxicology Letters
- Regulation of PXR and CAR by protein-protein interaction and signaling crosstalkPeter O. Oladimeji, Hongmei Cui, Chen Zhang, Taosheng Chen · 2016 · Expert Opinion on Drug Metabolism & Toxicology
- Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge and Clinical SignificanceAmal Al‐Omari, Daryl J. Murry · 2007 · Journal of Pharmacy Practice
- Lessons from the CYP3A4 PromoterErin G. Schuetz · 2004 · Molecular Pharmacology
- Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in CirrhosisRaj Vuppalanchi, Tiebing Liang, Chirayu Pankaj Goswami, Rohit Nalamasu, Lang Li, David R. Jones, Rongrong Wei, Wanqing Liu, Vishal Sarsani, Sarath Chandra Janga et al. · 2013 · PLoS ONE
- Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5Matthew G. Soars, Ken Grime, Robert J. Riley · 2006 · Xenobiotica
- A SIGNIFICANT DRUG-METABOLIZING ROLE FOR CYP3A5?J. Andrew Williams, Jack Cook, Susan I. Hurst · 2003 · Drug Metabolism and Disposition
- Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in miceJun Yao, Chenggang Li, Likun Gong, Chenchen Feng, Chun-zhu Li, Man Gao, Yang Luan, Xinming Qi, Jin Ren · 2013 · Acta Pharmacologica Sinica
- A Review of CYP3A Drug-Drug Interaction Studies: Practical Guidelines for Patients Using Targeted Oral Anticancer DrugsLaura Molenaar‐Kuijsten, Dorieke E M van Balen, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema · 2021 · Frontiers in Pharmacology
- Impact of CYP3A5 Genotype on Tacrolimus Versus Midazolam Clearance in Renal Transplant Recipients: New Insights in CYP3A5-Mediated Drug MetabolismHylke de Jonge, Henriëtte de Loor, Kristin Verbeke, Yves F. Ch. Vanrenterghem, Dirk R. J. Kuypers · 2013 · Pharmacogenomics
- Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancerSusanna Leskelä, Emiliano Honrado, Cristina Montero‐Conde, Iñigo Landa, Alberto Cascón, Rocío Letón, Paloma Talavera, Jose M. Cozar, A Concha, Mercedes Robledo et al. · 2007 · Endocrine Related Cancer
- Correlates of Efavirenz Exposure in Chilean Patients Affected With Human Immunodeficiency Virus Reveals a Novel Association With a Polymorphism in the Constitutive Androstane ReceptorClaudia P. Cortés, Marco Siccardi, Ammara Chaikan, Andrew Owen, Guijun Zhang, Charles J. L. la Porte · 2012 · Therapeutic Drug Monitoring
- Identification of Cytochrome P450 Enzymes Involved in the Metabolism of FK228, a Potent Histone Deacetylase Inhibitor, in Human Liver MicrosomesToshifumi Shiraga, Zenzaburo Tozuka, Rika Ishimura, Akio Kawamura, Akira Kagayama · 2005 · Biological and Pharmaceutical Bulletin
- Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5Theresa Mariero Klees, Pamela R. Sheffels, Kenneth E. Thummel, Evan D. Kharasch · 2005 · Anesthesiology
- The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery SettingCharles J. O’Donnell, Ken Grime, Paul F. Courtney, Dean Slee, Robert J. Riley · 2006 · Drug Metabolism and Disposition
- Genetic variability in cytochrome P450 3A5 and in vivo cytochrome P450 3A activity: Some answers but still questions*1Grant R. Wilkinson · 2004 · Clinical Pharmacology & Therapeutics
- Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populationsZoe E. Barter, H. F. Perrett, Karen Rowland Yeo, Delphine Allorge, Martin S Lennard, Amin Rostami‐Hodjegan · 2010 · Biopharmaceutics & Drug Disposition
- Metabolism of Beclomethasone Dipropionate by Cytochrome P450 3A EnzymesJessica K. Roberts, Chad D. Moore, Robert M. Ward, Garold S. Yost, Christopher A. Reilly · 2013 · Journal of Pharmacology and Experimental Therapeutics
- Identification of polymorphisms in the 3′-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolismLauren E. Oleson, Lisa Lvon Moltke, David J. Greenblatt, Michael H. Court · 2010 · Xenobiotica
- Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymesAllan B. Okey, Paul Christopher Boutros, Patricia A. Harper · 2005 · Pharmacogenetics and Genomics
- Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme inductionCurtis E. Haas, Daniel Alan Brazeau, Denise Cloen, Brent M. Booker, Valerie A. Frerichs, Colleen Zaranek, Reginald F. Frye, Thomas J. Kufel · 2005 · European Journal of Clinical Pharmacology
- CYP3A5*3 and CYP3A4*1B Allele Distribution and Genotype Combinations: Differences Between Spaniards and Central AmericansB. Sinués, Jorge Vicente-Romero, Ana Fanlo, Patricia Vásquez, Juan Carlos Medina, E Mayayo, Blanca Conde, Izaskún Arenaz, Begoña Martínez‐Jarreta · 2007 · Therapeutic Drug Monitoring
- Expression of Cytochromes P450 3A and P‐Glycoprotein in Human Large Intestinse in Paired Tumour and Normal SamplesRoberto Canaparo, Anna Nordmark, Niklas Finnström, Stefan Lundgren, Janeric Seidegård, Bengt W. Jeppsson, Robert Jeffrey Edwards, Alan R. Boobis, Anders Rane · 2006 · Basic & Clinical Pharmacology & Toxicology
- The CYP3A4*18 Allele, the Most Frequent Coding Variant in Asian Populations, Does Not Significantly Affect the Midazolam Disposition in Heterozygous IndividualsSu‐Jun Lee, Sang Seop Lee, Hye‐Eun Jeong, Ji‐Hong Shon, Ji-Young Ryu, Yu Eun Sunwoo, Kwang‐Hyeon Liu, Wonku Kang, Young-Ju Park, Chi-Mann Shin et al. · 2007 · Drug Metabolism and Disposition
- Effect of Age on in Vitro Triazolam Biotransformation in Male Human Liver MicrosomesKiran C. Patki, Lisa Lvon Moltke, Jerold S. Harmatz, Leah M. Hesse, Michael H. Court, David J. Greenblatt · 2004 · Journal of Pharmacology and Experimental Therapeutics
- Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus MonkeysYasuharu Nakanishi, Akinori Matsushita, Kiyomi Matsuno, Kazuhide Iwasaki, Masahiro Utoh, Chika Nakamura, Yasuhiro Uno · 2010 · Drug Metabolism and Pharmacokinetics
- Pharmacogenetics of Vascular Risk Factors in Alzheimer’s DiseaseRamón Cacabelos, Arun Meyyazhagan, Juan C. Carril, Pablo Cacabelos, Óscar Teijido · 2018 · Journal of Personalized Medicine
- Role of reactive metabolites in the circulation in extrahepatic toxicityRoy M. Irving, Adnan A. Elfarra · 2012 · Expert Opinion on Drug Metabolism & Toxicology
- Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T CellsRucha S Sane, Donna J. Buckley, Arthur R. Buckley, Srikanth C. Nallani, Pankaj B. Desai · 2008 · Drug Metabolism and Disposition
- Introduction to Clinical PharmacologyRommel G. Tirona, Richard B. Kim · 2016 · Elsevier eBooks
- CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantationYue Dong, Qinxia Xu, Ruidong Li, Yifeng Tao, Quanbao Zhang, Jianhua Li, Zhenyu Ma, Conghuan Shen, Mingkang Zhong, Zhengxin Wang et al. · 2021 · Gene
- Recent developments and future directions for the use of pharmacogenomics in cardiovascular disease treatmentsElliot M. Berinstein, Andrew P. Levy · 2017 · Expert Opinion on Drug Metabolism & Toxicology
- CYP3A phenotypes and genotypes in North IndiansNaushad Rais, Yogesh Kumar Chawla, Krishan Kumar Kohli · 2006 · European Journal of Clinical Pharmacology
- Marmoset Cytochrome P450 3A4 Ortholog Expressed in Liver and Small-Intestine Tissues Efficiently Metabolizes Midazolam, Alprazolam, Nifedipine, and TestosteroneShotaro Uehara, Yasuhiro Uno, Kazuyuki Nakanishi, Sakura Ishii, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki · 2017 · Drug Metabolism and Disposition
- A Novel Polymorphic Cytochrome P450 Formed by Splicing of CYP3A7 and the Pseudogene CYP3AP1Cristina Rodríguez‐Antona, Magnus Axelson, Charlotta A. Otter, Anders Rane, Magnus Ingelman‐Sundberg · 2005 · Journal of Biological Chemistry
- Expression and activity of taxane-metobolizing enzymes in ovarian tumorsJulie A. DeLoia, William C. Zamboni, Jacqueline M. Jones, Sandra Strychor, Joseph Leo Kelley, Holly H. Gallion · 2007 · Gynecologic Oncology
- Influence of CYP3A4 genotypes in the outcome of serous ovarian cancer patients treated with first-line chemotherapy: implication of a CYP3A4 activity profile.Joana Assis, Deolinda Pereira, Mónica Patrícia Gomes, Dânia Sofia Marques, Inês Marques, Augusto Nogueira, Raquel Catarino, Rui Medeiros · 2013 · Europe PMC (PubMed Central)
- Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African AmericansMinoli A. Perera, Ranjit Kumar Thirumaran, Nancy Jean Cox, Stephen B. Hanauer, Soma Das, Cynthia Brimer, Vishal Lamba, Erin G. Schuetz, Mark J. Ratain, Anna Di Rienzo · 2008 · The Pharmacogenomics Journal
- Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine ChansuZiru Dai, Jing Ning, Guibo Sun, Ping Wang, Feng Zhang, Hongying Ma, Li‐Wei Zou, Jie Hou, Jingjing Wu, Guang‐Bo Ge et al. · 2019 · Frontiers in Pharmacology
- Transcriptional regulation of CYP3A4 by nuclear receptors in human hepatocytes under hypoxiaXuechun Yuan, Hui Lu, Anpeng Zhao, Yidan Ding, Qiong Min, Rong Wang · 2020 · Drug Metabolism Reviews
- Variability in Expression of CYP3A5 in Human Fetal LiverCarrie A. Vyhlidal, Robin E. Pearce, Roger Gaedigk, Justina C. Calamia, Diana L. Shuster, Kenneth E. Thummel, James Steven Leeder · 2015 · Drug Metabolism and Disposition
- Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational DiabetesGregory J. Anger, Micheline Piquette‐Miller · 2011 · Drug Metabolism and Disposition
- Limited contribution of CYP3A5 to the hepatic 6?-hydroxylation of testosteroneLandry K. Kamdem, Ingolf Meineke, Ina Koch, Ulrich M. Zanger, J rgen Brockm ller, Leszek Wojnowski · 2004 · Naunyn-Schmiedeberg s Archives of Pharmacology
- Hormonal Regulation of Hepatic Drug Biotransformation and Transport SystemsMaría L. Ruiz, Aldo Domingo Mottino, Viviana Alicia Catania, Mary E. Vore · 2013 · Comprehensive physiology
- Nilotinib for imatinib-resistant or -intolerant chronic myeloid leukemia in chronic phase, accelerated phase, or blast crisis: A single- and multiple-dose, open-label pharmacokinetic study in Chinese patientsLi Zhou, Fan‐Yi Meng, Ophelia Q. P. Yin, Jianxiang Wang, Ying Wang, Yongqiang Wei, Pei Hu, Zhixiang Shen · 2009 · Clinical Therapeutics
- CYP3APharmacogenetic Association with Tacrolimus Pharmacokinetics Differs Based on Route of Drug AdministrationAmy L. Pasternak, Lu Zhang, Daniel L. Hertz · 2018 · Pharmacogenomics
- Interacciones farmacológicas de los fármacos antihipertensivosFrancisco J. Morales‐Olivas, Luís Estañ · 2005 · Medicina Clínica
- A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp SimulatorLiam Curry, Sarah Alrubia, Frédéric Y. Bois, Ruth Clayton, Eman El‐Khateeb, Trevor N. Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami‐Hodjegan · 2024 · CPT Pharmacometrics & Systems Pharmacology
- Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpineJia Ning, Ivonne M.C.M. Rietjens, Marije Strikwold · 2019 · Archives of Toxicology
- Pleiotropy and Promiscuity in Pharmacogenomics for the Treatment of Alzheimer's Disease and Related risk factorsRamón Cacabelos · 2018 · Future Neurology
- Diets Containing Soy Protein Isolate Increase Hepatic CYP3A Expression and Inducibility in Weanling Male Rats Exposed during Early DevelopmentMartin J. J. Ronis, Ying Chen, Chan-He Jo, Pippa Margaret Simpson, Thomas M. Badger · 2004 · Journal of Nutrition
- Study of urinary 6β-hydroxycortisol/cortisol ratio in spot urine sample as a biomarker of 3A4 enzyme activity in healthy and epileptic subjects of Egyptian populationEhab S. EL Desoky, Hanan O. Mohamed, Wafaa M. A. Farghaly, Sherifa Ahmed Hamed, Mohsen A. Hedaya, Jean-Pascal Siest · 2005 · Pharmacological Research
- Transcription Factor Binding to a Putative Double E-Box Motif Represses CYP3A4 Expression in Human Lung CellsJason S. Biggs, Jie Wan, N. Shane Cutler, Jukka Hakkola, Päivi Uusimäki, Hannu Raunio, Garold S. Yost · 2007 · Molecular Pharmacology
- Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancerEmanuel Buck, Martin Ronald Sprick, Matthias M. Gaida, Carsten Grüllich, Tim Frederik Weber, Esther Herpel, Thomas M. Bruckner, Ronald Koschny · 2019 · Oncology Letters
- Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 EnzymesH. F. Perrett, Zoe E. Barter, B. C. Jones, Hiroshi Yamazaki, GT Tucker, Amin Rostami‐Hodjegan · 2007 · Drug Metabolism and Disposition
- CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratioWentao Hu, Xiaoteng Cui, Hongyu Liu, Ze Li, Xu Chen, Qixue Wang, G J Zhang, Er Wen, Jinxin Lan, Junyi Chen et al. · 2025 · Journal of Experimental & Clinical Cancer Research
- A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression SystemSu‐Jun Lee, Ilse P. van der Heiden, Joyce A. Goldstein, Ron H. N. van Schaik · 2006 · Drug Metabolism and Disposition
- DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expressionXiaofei Wang, Luman Wei, Jingke Yang, Yiting Wang, Shitong Chen, Kun Yang, Xiangguang Meng, Lirong Zhang · 2020 · Clinical and Experimental Pharmacology and Physiology
- Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model inputShensheng Zhao, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens, Marije Strikwold · 2022 · Archives of Toxicology
- Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problemMaria A. Croyle · 2009 · Expert Opinion on Drug Metabolism & Toxicology
- Reduced Methylprednisolone Clearance Causing Prolonged Pharmacodynamics in a Healthy Subject Was Not Associated WithCYP3A5*3Allele or a Change in Diet CompositionSu‐Jun Lee, William J. Jusko, Christine G. Salaita, Karim A. Calis, Michael W. Jann, Vicky E. Spratlin, Joyce A. Goldstein, Yuen Yi Hon · 2006 · The Journal of Clinical Pharmacology
- In vitroassessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450enzyme identification, inhibition, and induction studiesYan Li, Diansong Zhou, Stephen Ferguson, Peter N. Dorff, Thomas R. Simpson, Scott W. Grimm · 2010 · Xenobiotica
- Single nucleotide polymorphism characterization by mRNA expression imbalance assessmentLeszek Wojnowski, J rgen Brockm ller · 2004 · Pharmacogenetics
- In vitro phase I metabolism of gamabufotalin and arenobufagin: Reveal the effect of substituent group on metabolic stabilityYujie Feng, Chao Wang, Xiangge Tian, Xiaokui Huo, Lei Feng, Cheng‐Peng Sun, Guang‐Bo Ge, Ling Yang, Jing Ning, Xiaochi Ma · 2017 · Fitoterapia
- Principles of PharmacogenomicsY. W. Francis Lam · 2019 · Elsevier eBooks
- CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer PatientsRuben A.G. van Eerden, Nikki S. IJzerman, Milan van Meekeren, Esther Oomen‐de Hoop, Niels A.D. Guchelaar, Andrea M. W. Visser, Maja Matić, Ron H. N. van Schaik, Peter de Bruijn, Dirk-Jan A. R. Moes et al. · 2023 · Clinical Pharmacokinetics
- Regulation of CYP3A genes by glucocorticoids in human lung cellsJessica K. Roberts, Chad D. Moore, Erin Gregory Romero, Robert M. Ward, Garold S. Yost, Christopher A. Reilly · 2013 · F1000Research
- The influence of a standardized soybean extract (Glycine max) on the expression level of cytochrome P450 genes in vivo.Przemysław Michał Mrozikiewicz, Anna Bogacz, Bogusław Czerny, Monika Karasiewicz, Radosław Kujawski, Przemysław Łukasz Mikołajczak, Agnieszka Seremak‐Mrozikiewicz, Edmund Grześkowiak, Teresa Bobkiewicz-Kozłowska · 2010 · PubMed
- Principles of PharmacogenomicsY. W. Francis Lam, Larisa H. Cavallari · 2013 · Elsevier eBooks
- Cloning, Expression, and Characterization of CYP3A43 in Cynomolgus Macaque (Macaca fascicularis)Yasuhiro Uno, Kiyomi Matsuno, Chika Nakamura, Masahiro Utoh, Hiroshi Yamazaki · 2009 · Drug Metabolism Letters
- The limited impact of CYP3A5 genotype for the pharmacokinetics of CYP3A substratesOliver Burk, Matthias Georg Schwab · 2007 · European Journal of Clinical Pharmacology
- Sex differences in hepatic enzymes and transporters involved in pharmacokineticsMehak Behal, Zachary McCalla, Xinwen Wang · 2025 · Liver Research
- Effects of CYP3A4*1G and CYP3A5*3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjectsSufeng Zhou, Mingxue Tao, Yuanyuan Wang, Lu Wang, Lijun Xie, Juan Chen, Yuqing Zhao, Yun Liu, Hongwen Zhang, Ning Ou et al. · 2018 · Xenobiotica
- Pharmacogenomics of Tamoxifen and Irinotecan TherapiesAlicia Algeciras-Schimnich, Dennis J. O’Kane, Christine L.H. Snozek · 2008 · Clinics in Laboratory Medicine
- CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndromeValentin Yurievich Skryabin, Johan Franck, Volker Martin Lauschke, Михаил Сергеевич Застрожин, Шипицын Валерий Валериевич, Evgeny Alekseevich Bryun, Dmitry Alekseevich Sychev · 2022 · Nordic Journal of Psychiatry
- CYP3A5*3, CYP3A4*1B and MDR1 C3435T Genotype Distributions in EcuadoriansB. Sinués, Jorge Vicente-Romero, Ana Fanlo, E. Mayayo Sinués, Fabricio González‐Andrade, Dora Sánchez-Q, Begoña Martínez‐Jarreta · 2008 · Disease Markers
- Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 PolymorphismsRachda Riffi, Wefa Boughrara, Amina Chentouf, Wassila Ilias, Narimene Malika Taieb Brahim, Amel Alioua Berrebbah, Fatma Belhoucine · 2024 · CNS & Neurological Disorders - Drug Targets
- Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A PolymorphismsRobin Taylor Wilson, Loren D. Masters, Jill S. Barnholtz‐Sloan, Anna C. Salzberg, Terryl J. Hartman · 2017 · American Journal of Epidemiology
- Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial TreatmentLeyre Pernaute-Lau, Ayôla Akim Adégnika, Yitian Zhou, Jeannot Frejus Zinsou, José Pedro Gil, Sanjeev Krishna, Peter G. Kremsner, Volker Martin Lauschke, Thirumalaisamy Palanichamy Velavan · 2021 · Antimicrobial Agents and Chemotherapy
- Prediction of human hepatic clearance with HepaSH monolayers for low-turnover compoundsShotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu · 2025 · Drug Metabolism and Disposition
- Differences of Atomic-Level Interactions between Midazolam and Two CYP Isoforms 3A4 and 3A5Shuhui Liu, Qing‐Chuan Zheng, Fu‐Quan Bai · 2023 · Molecules
- CYP3A gene variability and cancer cells response to the treatmentMartina Šemeláková, Lenka Maliničová, Mária Macejová, Peter Pristaš · 2021 · General Physiology and Biophysics
- Pazopanib-related tumor lysis syndrome in metastatic clear cell renal cell carcinoma: a case reportMichael W. van Kalleveen, Maudy Walraven, Mathijs P. Hendriks · 2018 · Investigational New Drugs
- MarmosetCYP3A21, a model for humanCYP3A4: Protein expression and functional characterization of the promoterSigrid Koehler, Nicolas von Ahsen, Christina Schlumbohm, Abdul Rahman Asif, Ute Gödtel‐Armbrust, Michael Oellerich, Leszek Wojnowski, Victor W. Armstrong · 2006 · Xenobiotica
- Future of the Pharmacogenomics of Calcineurin Inhibitors in Renal Transplant PatientsHuaijun Zhu, Weihong Ge · 2011 · Pharmacogenomics
- Cytochrome P450 enzymes— in vitro , in vivo , and in silico studiesMiia Turpeinen · 2006
- Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgeryJingjing Yuan, Xiaojing Ma, Zhisong Li, Yanzi Chang, Wei Zhang, Quancheng Kan, Junkai Hou, Lirong Zhang · 2016 · BMC Medical Genetics
- Population Pharmacokinetic/Pharmacogenetic Model of Lopinavir/Ritonavir in HIV-Infected PatientsElena López Aspiroz, Dolores Santos Buelga, Salvador Enrique Cabrera Figueroa, María de la Paz Valverde Merino, The Tormes Team, Miguel Cordero Sánchez, Alfonso Domínguez-Gil Hurlé, Ángel Carracedo, María José García Sánchez · 2014 · Personalized Medicine
- Genetic Determinants of Response to Statins in Cardiovascular DiseasesGhazaleh Ghorbannezhad, Shima Mehrabadi, Negar Golampour-Shamkani, Amir Hossein Barjasteh, Poorya Etesamizadeh, Mohammad Tayyebi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan · 2024 · Current Cardiology Reviews
- Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single SubstratesClaudio Erratico, Anand K. Deo, Stelvio M. Bandiera · 2015 · Advances in experimental medicine and biology
- Interplay of drug metabolizing enzymes with cellular transportersMichaela Böhmdorfer, Alexandra Maier‐Salamon, Juliane Riha, Stefan Brenner, Martina Höferl, Walter Rudolf Jäger · 2014 · Wiener Medizinische Wochenschrift