The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
Cook, D., Brown, D., Alexander, R., March, R., Morgan, P., Satterthwaite, G., & Pangalos, M. N. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4309 · Cited by 1,344
Arch, J. R. S. (2008) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-008-0271-1 · Cited by 96
Research works printed but not linked: 54
- Abrams, 2007, Muscarinic receptor antagonists for overactive bladder, BJU Int, 100, 987, 10.1111/j.1464-410X.2007.07205.x · DOI · Paper page
- Abrams, 2002, The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society, Neurourol Urodyn, 21, 167, 10.1002/nau.10052 · DOI · Paper page
- Abrams, 2015, Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomised, double-blind, dose-ranging, phase 2 study (Symphony), Eur Urol, 67, 577, 10.1016/j.eururo.2014.02.012 · DOI
- Ahlquist, 1948, A study of the adrenotropic receptors, Am J Physiol, 153, 586, 10.1152/ajplegacy.1948.153.3.586 · DOI
- Anderson, 1993, Pharmacology of lower urinary tract smooth muscles and penile erectile tissues, Pharmacol Rev, 45, 253, 10.1016/S0031-6997(25)00442-9 · DOI
- Andersson, 2015, Purinergic signalling in the urinary bladder, Auton Neurosci, 191, 78, 10.1016/j.autneu.2015.04.012 · DOI
- Andersson, 2004, Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence, Pharmacol Rev, 56, 581, 10.1124/pr.56.4.4 · DOI · Paper page
- Beckel, 2011, Neurophysiology of the lower urinary tract, Handb Exp Pharmacol, 202, 149, 10.1007/978-3-642-16499-6_8 · DOI
- Berkowitz, 1995, Distribution of beta 3-adrenoceptor mRNA in human tissues, Eur J Pharmacol, 289, 223, 10.1016/0922-4106(95)90098-5 · DOI
- Birder, 2007, Mechanisms of disease: involvement of the urothelium in bladder dysfunction, Nat Clin Pract Urol, 4, 46, 10.1038/ncpuro0672 · DOI · Paper page
- Bordicchia, 2014, Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes, J Hypertens, 32, 389, 10.1097/HJH.0000000000000024 · DOI
- Candelore, 1999, Potent and selective human beta(3)-adrenergic receptor antagonists, J Pharmacol Exp Ther, 290, 649, 10.1016/S0022-3565(24)34946-8 · DOI
- Cernecka, 2014, The odd sibling: features of β3-adrenoceptor pharmacology, Mol Pharmacol, 86, 479, 10.1124/mol.114.092817 · DOI
- Chapple, 2014, Mirabegron in overactive bladder: a review of efficacy, safety, and tolerability, Neurourol Urodyn, 33, 17, 10.1002/nau.22505 · DOI
- Chapple, 2008, The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis, Eur Urol, 54, 543, 10.1016/j.eururo.2008.06.047 · DOI · Paper page
- Coyne, 2011, National community prevalence of overactive bladder in the United States stratified by sex and age, Urology, 77, 1081, 10.1016/j.urology.2010.08.039 · DOI · Paper page
- De Nunzio, 2015, The current indications and the benefits of combining a β3-agonist with an anticholinergic for the treatment of OAB, Curr Drug Targets, 16, 1198, 10.2174/1389450116666150806124345 · DOI
- Drake, 2008, Emerging drugs for treatment of overactive bladder and detrusor overactivity, Expert Opin Emerg Drugs, 13, 431, 10.1517/14728214.13.3.431 · DOI
- Edmondson, 2016, Discovery of vibegron: a potent and selective β3 adrenergic receptor agonist for the treatment of overactive bladder, J Med Chem, 59, 609, 10.1021/acs.jmedchem.5b01372 · DOI
- Ehlert, 2007, Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder, J Pharmacol Exp Ther, 322, 631, 10.1124/jpet.107.121756 · DOI
- Ehlert, 2005, The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder, J Pharmacol Exp Ther, 313, 368, 10.1124/jpet.104.077909 · DOI
- Emorine, 1989, Molecular characterization of the human beta 3-adrenergic receptor, Science, 245, 1118, 10.1126/science.2570461 · DOI
- Fowler, 2008, The neural control of micturition, Nat Rev Neurosci, 9, 453, 10.1038/nrn2401 · DOI · Paper page
- Furuta, 2016, Combination therapy with β3 -adrenoceptor agonists and muscarinic acetylcholine receptor antagonists: Efficacy in rats with bladder overactivity, Int J Urol, 23, 425, 10.1111/iju.13066 · DOI
- Furuta, 2006, The promise of beta3-adrenoceptor agonists to treat the overactive bladder, Urol Clin North Am, 33, 539, 10.1016/j.ucl.2006.06.014 · DOI
- Gillespie, 2015, Beta adrenergic modulation of spontaneous microcontractions and electrical field-stimulated contractions in isolated strips of rat urinary bladder from normal animals and animals with partial bladder outflow obstruction, Naunyn Schmiedebergs Arch Pharmacol, 388, 719, 10.1007/s00210-015-1136-z · DOI
- Harmon, 2005, Beta-adrenergic receptor activation in immortalized human urothelial cells stimulates inflammatory responses by PKA-independent mechanisms, Cell Commun Signal, 3, 10, 10.1186/1478-811X-3-10 · DOI
- Irwin, 2006, Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study, Eur Urol, 50, 1306, 10.1016/j.eururo.2006.09.019 · DOI · Paper page
- Kullmann, 2011, Urothelial beta-3 adrenergic receptors in the rat bladder, Neurourol Urodyn, 30, 144, 10.1002/nau.20965 · DOI
- Kosilov, 2015, A randomized, controlled trial of effectiveness and safety of management of OAB symptoms in elderly men and women with standard-dosed combination of solifenacin and mirabegron, Arch Gerontol Geriatr, 61, 212, 10.1016/j.archger.2015.06.006 · DOI
- Lands, 1967, Differentiation of receptor systems activated by sympathomimetic amines, Nature, 214, 597, 10.1038/214597a0 · DOI · Paper page
- Limberg, 2010, β-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder, Cell Tissue Res, 342, 295, 10.1007/s00441-010-1053-x · DOI
- Longnecker, 1966, A program for automated hematoxylin and eosin staining, Am J Clin Pathol, 45, 229, 10.1093/ajcp/45.2_ts.229 · DOI
- Maruyama, 2012, Effects of ritobegron (KUC-7483), a novel selective β3-adrenoceptor agonist, on bladder function in cynomolgus monkey, J Pharmacol Exp Ther, 342, 163, 10.1124/jpet.112.191783 · DOI
- Masunaga, 2010, The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome, Neurourol Urodyn, 29, 1320, 10.1002/nau.20838 · DOI
- Matsui, 2003, Increased relaxant action of forskolin and isoproterenol against muscarinic agonist-induced contractions in smooth muscle from M2 receptor knockout mice, J Pharmacol Exp Ther, 305, 106, 10.1124/jpet.102.044701 · DOI
- Matsumoto, 2012, Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats, Urology, 79, 1184.e15, 10.1016/j.urology.2012.01.022 · DOI
- Michel, 2016, β3-Adrenoceptor agonists for overactive bladder syndrome: Role of translational pharmacology in a repositioning clinical drug development project, Pharmacol Ther, 159, 66, 10.1016/j.pharmthera.2016.01.007 · DOI
- Morgan, 2012, Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival, Drug Discov Today, 17, 419, 10.1016/j.drudis.2011.12.020 · DOI · Paper page
- Moyes, 2014, Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder, J Med Chem, 57, 1437, 10.1021/jm4017224 · DOI
- Nagabukuro, 2011, Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents, J Pharmacol Exp Ther, 338, 220, 10.1124/jpet.111.179747 · DOI
- Nomiya, 2003, A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders, J Urol, 170, 649, 10.1097/01.ju.0000067621.62736.7c · DOI
- Ohlstein, 2012, A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder, Eur Urol, 62, 834, 10.1016/j.eururo.2012.05.053 · DOI
- Ohtake, 2007, Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents, Biol Pharm Bull, 30, 54, 10.1248/bpb.30.54 · DOI
- Otsuka, 2013, Expression of β-adrenoceptor subtypes in urothelium, interstitial cells and detrusor of the human urinary bladder, Low Urin Tract Symptoms, 5, 173, 10.1111/luts.12007 · DOI
- Otsuka, 2008, Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium, Naunyn Schmiedebergs Arch Pharmacol, 377, 473, 10.1007/s00210-008-0274-y · DOI
- Propping, 2013, Mucosa of human detrusor impairs contraction and β-adrenoceptor-mediated relaxation, BJU Int, 112, 1215, 10.1111/bju.12267 · DOI
- Rouget, 2014, Modulation of nerve-evoked contractions by β3-adrenoceptor agonism in human and rat isolated urinary bladder, Pharmacol Res, 80, 14, 10.1016/j.phrs.2013.12.006 · DOI
- Tallarida, 2001, Drug synergism: its detection and applications, J Pharmacol Exp Ther, 298, 865, 10.1016/S0022-3565(24)29450-7 · DOI · Paper page
- Thomas, 1993, Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human, Mol Pharmacol, 43, 343, 10.1016/S0026-895X(25)13619-5 · DOI
- Tyagi, 2010, Mirabegron, a β3-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder, IDrugs, 13, 713
- Uhlén, 2015, Proteomics. Tissue-based map of the human proteome, Science, 347, 1260419, 10.1126/science.1260419 · DOI · Paper page
- Ursino, 2009, The beta3-adrenoceptor as a therapeutic target: current perspectives, Pharmacol Res, 59, 221, 10.1016/j.phrs.2009.01.002 · DOI
- Wang, 1995, Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins, J Pharmacol Exp Ther, 273, 959, 10.1016/S0022-3565(25)09628-4 · DOI
Metadata
- Authors
- Di Salvo, J., Nagabukuro, H., Wickham, L. A., Abbadie, C., DeMartino, J. A., Fitzmaurice, A., Gichuru, L., Kulick, A., Donnelly, M. J., Jochnowitz, N., Hurley, A. L., Pereira, A., Sanfiz, A., Veronin, G., Villa, K., Woods, J., Zamlynny, B., Zycband, E., Salituro, G. M., Frenkl, T., Weber, A. E., Edmondson, S. D., & Struthers, M.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 360
- Issue
- 2
- Pages
- 346-355
- ISSN
- 0022-3565
- Cited by
- 58
- References
- 2
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder. https://app.cochat.ai/papers/10.1124/jpet.116.237313
- The paper
- Di Salvo, J., Nagabukuro, H., Wickham, L. A., Abbadie, C., DeMartino, J. A., Fitzmaurice, A., Gichuru, L., Kulick, A., Donnelly, M. J., Jochnowitz, N., Hurley, A. L., Pereira, A., Sanfiz, A., Veronin, G., Villa, K., Woods, J., Zamlynny, B., Zycband, E., Salituro, G. M., . . . Struthers, M. (2017). Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.116.237313
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.