LTP May Trigger Addiction
Open accessAbstract
Differing classes of abused drugs utilize different mechanisms of molecular pharmacological action yet the overuse of these same drugs frequently leads to the same outcome: addiction. Similarly, episodes of stress can lead to drug-seeking behaviors and relapse in recovering addicts. To overcome the labor-intensive headache of having to design a specific addiction-breaking intervention tailored to each drug it would be expedient to attack the cycle of addiction at targets common to such seemingly disparate classes of drugs of abuse. Recently, encouraging observations were made whereby stressful conditions and differing classes of drugs of abuse were found to impinge upon the same excitatory synapses on dopamine neurons in the midbrain. These findings will increase our understanding of the intricacies of addiction and LTP, and may lead to new interventions for breaking addiction.
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Addictive drugs have profound effects on synaptic transmission that may influence LTP and LTD.
“Addictive drugs also have profound effects on synaptic transmission that may influence LTP and LTD (Wolf 2003;Kauer and Malenka 2007;Lu ¨scher and Malenka 2011).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Wolf 2003
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References 23 · Cited by 51
- Authors
- Wolf, M. E.
- Corresponding author
- Wolf, M. E.
- ORCID
- Wolf, M. E.
- Venue
- Molecular Interventions
- Publisher
- CLOCKSS Archive
- Published
- 2003-08-01
- Volume
- 3
- Issue
- 5
- Pages
- 248-252
- ISSN
- 1534-0384 (ISSN-L)
- OpenAlex
- W2036665996
- Cited by
- 51
- References
- 23
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2015: 4 · 2012: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Molecular Interventions (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- long-term potentiation, drug addiction, stress, relapse, drug-seeking behavior, dopaminergic neurons, midbrain, excitatory synapses, addiction treatment
- MeSH terms
- Animals, Dopamine, Neurons, Reward, Illicit Drugs, Ventral Tegmental Area, Long-Term Potentiation, Substance-Related Disorders
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