The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cardiac Glycosides as Novel Cancer Therapeutic Agents
Abstract
The class of steroid-like compounds designated cardiac glycosides includes well-known drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy in treatment of congestive heart failure and as anti-arrhythmic agents is well appreciated. Less well known, however, is the emerging role of this category of compounds in the prevention and/or treatment of proliferative diseases such as cancer. New findings within the past five years have revealed these compounds to be involved in complex cell-signal transduction mechanisms, resulting in selective control of human tumor but not normal cellular proliferation. As such, they represent a promising form of targeted cancer chemotherapy. New clinical studies of their anticancer potential as single or adjuvant treatments may provide insight into these potentially valuable therapeutic options. This review focuses on recent findings on cellular pharmacology of cardiac glycosides as they relate to treatment of human cancer and attempts to explain why these agents have been overlooked in the past.
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Cites
Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells
Kometiani, P., Liu, L., & Askari, A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.007302 · Cited by 208
Stein (2000) · doi:10.1054/mehy.1999.0985 · Cited by 171
Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
López-Lázaro, M. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.8.1043 · Cited by 145
Structure–cytotoxic activity relationship for the toad poison bufadienolides
Kamano, Y., Kotake, A., Hashima, H., Inoue, M., Morita, H., Takeya, K., Itokawa, H., Nandachi, N., Segawa, T., Yukita, A., et al. (1998) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(98)00067-4 · Cited by 129
Cited by
Novel therapeutic applications of cardiac glycosides
Prassas, I., & Diamandis, E. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2682 · Cited by 673
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624
Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K. A., Green, D. R., Xavier, R. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319661110 · Cited by 607
Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets
Bagrov, A. Y., Shapiro, J. I., & Fedorova, O. V. (2009) · Pharmacological Reviews · doi:10.1124/pr.108.000711 · Cited by 532
Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Menger, L., Vacchelli, E., Adjemian, S., Martins, I., Ma, Y., Shen, S., Yamazaki, T., Sukkurwala, A. Q., Michaud, M., Mignot, G., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003807 · Cited by 423
Metadata
- Authors
- Newman, R. A., Yang, P., Pawlus, A. D., & Block, K. I.
- Venue
- Molecular Interventions
- Publisher
- CLOCKSS Archive
- Published
- 2008-02-01
- Volume
- 8
- Issue
- 1
- Pages
- 36-49
- ISSN
- 1534-0384 (ISSN-L)
- OpenAlex
- W2070358111
- Cited by
- 515
- References
- 4
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- closed
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