A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

Sperm-specific Expression of Angiotensin-Converting Enzyme (ACE) is Mediated by a 91-Base-Pair Promoter Containing a CRE-Like Element

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Biological activities of thymosin ß 4 defined by active sites in short peptide sequences

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Effect of angiotensin converting enzyme inhibitors on erythropoietin concentrations in healthy volunteers.

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Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction

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Historical Trends and Milestones in Hypertension Research: A Model of the Process of Translational Research

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Mice with Enhanced Macrophage Angiotensin-Converting Enzyme Are Resistant to Melanoma

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Rapid stimulation by vasopressin, oxytocin and angiotensin II of glycogen degradation in hepatocyte suspensions

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Tubuloglomerular feedback: mechanistic insights from gene-manipulated mice

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Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane

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Embryonic origin of human hematopoiesis

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Human Kallikrein Gene Delivery Attenuates Hypertension, Cardiac Hypertrophy, and Renal Injury in Dahl Salt-Sensitive Rats

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Region‐specific changes in sympathetic nerve activity in angiotensin II–salt hypertension in the rat

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Angiotensin II Type 1 Receptor–Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice

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Angiotensin II Induces Migration and Pyk2/Paxillin Phosphorylation of Human Monocytes

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THE RENIN-ANGIOTENSIN SYSTEM

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Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice

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High Plasma Level ofN-Acetyl-Seryl-Aspartyl-Lysyl-Proline

Azizi, M., Ezan, É., Nicolet, L., Grognet, J., & Ménard, J. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1015 · Cited by 104

Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference interval for adults

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Historical Perspective of the Renin-Angiotensin System

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Extracellular processing of peptide antigens that bind class I major histocompatibility molecules.

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Phosphinic peptides as zinc metalloproteinase inhibitors

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Angiotensin II–Mediated Microvascular Thrombosis

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Angiotensin II Type-2 Receptor Stimulation Prevents Neural Damage by Transcriptional Activation of Methyl Methanesulfonate Sensitive 2

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Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme.

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Serum angiotensin-converting enzyme. Isolation and relationship to the pulmonary enzyme.

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Angiotensin II–Mediated Phenotypic Cardiomyocyte Remodeling Leads to Age-Dependent Cardiac Dysfunction and Failure

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The Structure of Testis Angiotensin-Converting Enzyme in Complex with the C Domain-Specific Inhibitor RXPA380,

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Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis

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Importance of quantitative genetic variations in the etiology of hypertension

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Activation of the AT2 Receptor of Angiotensin II Induces Neurite Outgrowth and Cell Migration in Microexplant Cultures of the Cerebellum

Côté, F., Hung, T., Laflamme, L., Gallo, J., & Gallo‐Payet, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31686 · Cited by 97

Angiotensin converting enzyme gene I/D polymorphism, blood pressure and the renin-angiotensin system in Caucasian and Afro-Caribbean peoples.

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Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene Is Associated with Increased Plasma Angiotensin-Converting Enzyme Activity but Not with Increased Risk for Myocardial Infarction and Coronary Artery Disease

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Hypertension and acute myocardial infarction

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Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver

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Enhanced tubuloglomerular feedback during peritubular infusions of angiotensins I and II

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The Design and Properties of N‐Carboxyalkyldipeptide Inhibitors of Angiotensin‐Converting Enzyme

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Antifibrotic Effects ofN-Acetyl-Seryl-Aspartyl-Lysyl-Proline on the Heart and Kidney in Aldosterone-Salt Hypertensive Rats

Peng, H., Carretero, O. A., Raij, L. R., Yang, F., Kapke, A., & Rhaleb, N. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.794 · Cited by 95

ANGIOTENSIN INHIBITS ACTION OF VAGUS NERVE AT THE HEART

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The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

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Effects of Acute Angiotensin II Type 1 Receptor Antagonism and Angiotensin Converting Enzyme Inhibition on Plasma Fibrinolytic Parameters in Patients With Heart Failure

Vaughan, D. E., & Brown, N. J. (2000) · Circulation · doi:10.1161/01.cir.102.6.e43 · Cited by 94

Race: a drosophila homologue of the angiotensin converting enzyme

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Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE)

Bernstein, K. E., Shen, X. Z., González-Villalobos, R. A., Billet, S., Okwan-Duodu, D. K., Ong, F. S.-C., & Fuchs, S. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.11.001 · Cited by 93

Mouse models for melanoma: a personal perspective

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RXP 407, a Selective Inhibitor of the N-Domain of Angiotensin I-Converting Enzyme, Blocks in Vivo the Degradation of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro with No Effect on Angiotensin I Hydrolysis

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Angiotensin II Type 2 Receptor-Mediated Apoptosis of Cultured Neurons from Newborn Rat Brain

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The Group II Chaperonin TRiC Protects Proteolytic Intermediates from Degradation in the MHC Class I Antigen Processing Pathway

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The N Domain of Human Angiotensin-I-converting Enzyme

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Effects of Acute Angiotensin II Type 1 Receptor Antagonism and Angiotensin Converting Enzyme Inhibition on Plasma Fibrinolytic Parameters in Patients With Heart Failure

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Targeted Inactivation of the Ren-2 Gene in Mice

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Mechanism of angiotensin converting enzyme inhibitor-related anemia in renal transplant recipients

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Angiotensin receptor blockers suppress antigen‐specific T cell responses and ameliorate collagen‐induced arthritis in mice

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Cross-Talk Between Mineralocorticoid and Angiotensin II Signaling for Cardiac Remodeling

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CK2 Phosphorylates the Angiotensin-Converting Enzyme and Regulates Its Retention in the Endothelial Cell Plasma Membrane

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Direct and reversible inhibitory effect of the tetrapeptide acetyl-N- Ser-Asp-Lys-Pro (Seraspenide) on the growth of human CD34+ subpopulations in response to growth factors

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Aβ42-to-Aβ40- and Angiotensin-converting Activities in Different Domains of Angiotensin-converting Enzyme

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Spontaneous solubilization of membrane-bound human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells.

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Cardiovascular Phenotypes of Kinin B 2 Receptor– and Tissue Kallikrein–Deficient Mice

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Serum Angiotensin-Converting Enzyme Activity, Concentration, and Specific Activity in Granulomatous Interstitial Lung Disease, Tuberculosis, and COPD

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Association between activation of the renin-angiotensin system and secondary erythrocytosis in patients with chronic obstructive pulmonary disease

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Neural Mechanisms of Angiotensin II–Salt Hypertension: Implications for Therapies Targeting Neural Control of the Splanchnic Circulation

Osborn, J. W., Fink, G. D., & Kuroki, M. T. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0188-9 · Cited by 81

The carboxypeptidase ACE shapes the MHC class I peptide repertoire

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A highly conserved c-fmsgene intronic element controls macrophage-specific and regulated expression

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Platelet activation during angiotensin II infusion in healthy volunteers

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Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor β 1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 Rat

Pinto, Y. M., Pinto‐Sietsma, S., Philipp, T., Engler, S., Koβmehl, P., Hocher, B., Marquardt, H., Sethmann, S., Lauster, R., Merker, H., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.747 · Cited by 80

cAMP-response element modulator tau is a positive regulator of testis angiotensin converting enzyme transcription.

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Signaling via the Angiotensin-Converting Enzyme Enhances the Expression of Cyclooxygenase-2 in Endothelial Cells

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Affinity chromatographic purification of angiotensin converting enzyme

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ENALAPRIL (MK-421) AND THE WHITE CELL COUNT AND HAEMATOCRIT

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Renin-Angiotensin Inhibition in Systolic Heart Failure and Chronic Kidney Disease

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Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites

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Left ventricular size, mass, and function in relation to angiotensin-converting enzyme gene polymorphism in humans

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Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs

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Central angiotensin II has catabolic action at white and brown adipose tissue

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Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

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The Renin-Angiotensin System and Antihypertensive Drugs in Alzheimer's Disease: Current Standing of the Angiotensin Hypothesis?

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Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo

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Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-κB and survivin

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Peptidyl-dipeptidase A/angiotensin I-converting enzyme

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Accelerated recovery from irradiation injury by angiotensin peptides

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A deletion polymorphism in the angiotensin converting enzyme gene is not associated with coronary heart disease in an Austrian population

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Minor histocompatibility antigens

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Angiotensin I converting enzyme (ACE) gene polymorphism and essential hypertension in JapanEthnic difference of ACE genotype

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Muscle Delivery of Human Kallikrein Gene Reduces Blood Pressure in Hypertensive Rats

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An Essential Role in Molting and Morphogenesis of Caenorhabditis elegans for ACN-1, a Novel Member of the Angiotensin-converting Enzyme Family That Lacks a Metallopeptidase Active Site

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ANG II-induced cardiac molecular and cellular events: role of aldosterone

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Effect of angiotensin II and angiotensin(1–7) on hematopoietic recovery after intravenous chemotherapy

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Ac-SDKP Reverses Cardiac Fibrosis in Rats With Renovascular Hypertension

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Cardiac Hypertrophy and Microvascular Deficit in Kinin B2 Receptor Knockout Mice

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The isolation of angiotensin-converting enzyme cDNA.

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Proteolytic Release of Membrane-Bound Angiotensin-Converting Enzyme: Role of the Juxtamembrane Stalk Sequence

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Angiotensin II-induced Ca2+mobilization and prolactin release in normal and hyperplastic pituitary cells

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The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme

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A Crucial Role in Fertility for the Oyster Angiotensin-Converting Enzyme Orthologue CgACE

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Mechanisms of Fertilization—A View From the Study of Gene‐Manipulated Mice

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Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy

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Small but powerful: Short peptide hormones and their role in autoimmune inflammation

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Nontraditional Roles of Angiotensin-Converting Enzyme

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Renin angiotensin system and ASCVD

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Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild‐type angiotensin‐converting enzyme

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STIMULATORY ACTION OF ANGIOTENSIN II ON WATER AND ELECTROLYTE TRANSPORT BY THE PROXIMAL COLON OF THE RAT

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Effects of angiotensin II subtype 1 receptor blockade on cardiac fibrosis and sarcoplasmic reticulum Ca2+ handling in hypertensive transgenic rats overexpressing the Ren2 gene

Rothermund, L., Pinto, Y. M., Vetter, R., Herfort, N., Kossmehl, P. P., Neumayer, H., Paul, M., & Kreutz, R. H. (2001) · Journal of Hypertension · doi:10.1097/00004872-200108000-00015 · Cited by 16

Angiotensin-I converting enzyme inhibitors suppress angiogenesis and growth of esophageal carcinoma xenografts

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Increased Angiotensin II–Induced Hypertension and Inflammatory Cytokines in Mice Lacking Angiotensin-Converting Enzyme N Domain Activity

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Dose-dependent inhibitory effects of angiotensin II on visual responses of the rat superior colliculus: AT1 and AT2 receptor contributions

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Tissue Specific Expression of Testis Angiotensin Converting Enzyme is Not Determined by the −32 Nonconsensus TATA Motif

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Angiotensin II‐induced increase in myocardial distensibility and its modulation by the endocardial endothelium in the rabbit heart

Castro‐Chaves, P., Fontes‐Carvalho, R., Pintalhão, M., Pimentel‐Nunes, P., & Leite-Moreira, A. F. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2008.046458 · Cited by 11

L'enzyme de conversion de l'angiotensine : une protéase conservée au cours de l'évolution

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Effects of angiotensin II on visual evoked potentials in the superior colliculus of juvenile rats

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Classical Renin‐Angiotensin System in Kidney Physiology

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Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation

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Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure

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The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

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Mechanisms of weight regain after weight loss — the role of adipose tissue

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