A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

Yang, Mei, Liang, Chen, Swaminathan, Kunchithapadam, Herrlinger, Stephanie, Lai, Fan, Shiekhattar, Ramin, Chen, Jian-Fu·2016·Science Advances
DOI 10.1126/sciadv.1601167

Cited by (232)

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  3. Development of LNA gapmer oligonucleotide based therapy for FTD/ALS caused by the C9orf72 repeat expansion
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  5. Regulation of intracellular traffic by TBK1 and its relevance to ALS
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  8. Imaging and Quantifying Neuronal Autophagy to Determine the Autophagy Contribution to Neuronal and Dendritic Morphogenesis
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  10. Linkage of proteasomal impairment and autophagy activation by C9orf72 poly-GA aggregate formation
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  11. Faculty Opinions recommendation of Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.
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  12. C9orf72 Overexpression in Asthenozoospermia: Implications for Spermatogonia Proliferation through mitophagy and glucose metabolism
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  14. Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosis
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  15. RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
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  16. Autophagy and Neurodegenerative Diseases
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  17. The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair
    Shan Li, Shidong Xu, Feng Li, Qirui Zhao, Penghui Zhang, Qinghua Guan, Xiangxiang Sun, Jundong Bi, Hu Xiao, Yiyuli Tang et al. · 2026 · The EMBO Journal
  18. Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis
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  19. A validated antibody toolbox for ALS research
    Riham Ayoubi, Emma J. MacDougall, Ian McDowell, Michael Biddle, Bárbara T Ferreira, Congyao Zha, Marie‐France Dorion, Jay P. Ross, Sara González Bolívar, Vera Ruíz Moleón et al. · 2026 · eLife
  20. Additional file 1 of Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis
    Wan Yun Ho, Sheeja Navakkode, Liu, Fujia, Soong, Tuck Wah, Ling, Shuo-Chien · 2020 · Figshare
  21. Genetic aspects of amyotrophic lateral sclerosis
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  22. Promotion of asthenozoospermia by C9orf72 through suppression of spermatogonia activity via fructose metabolism and mitophagy
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  23. Effect of G 4 C 2 repeat expansions on the motion of lysosomes inside neurites
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  24. Étude de la composante neuroinflammatoire dans les DFT/SLA
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  25. Mechanisms of C9ORF72 pathogenicity and related autophagy impairment in amyotrophic lateral sclerosis
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  26. Structural and functional characterization of the lysosomal amino acid transporter PQLC2
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  27. Phosphoregulated SMCR8-FIP200 interaction connects the ALS/FTD-linked C9orf72 complex to autophagy initiation and mitochondrial quality control
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  28. Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show changes in energy metabolism but no cell pathologies
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  29. Chromosome 9 Open Reading Frame 72 as a Multifunctional Regulator of Cellular Homeostasis
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  30. TLR7-mediated autoimmunity targets Robo3 to drive astrogliosis in frontotemporal dementia
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  31. BindingDB Entry 50001184: UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target.
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  32. Exercise-induced lactylation in WDR41 initiates autophagy and improves fatty liver diseases
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