Serine one-carbon catabolism with formate overflow
Meiser, Johannes, Tumanov, Sergey, Maddocks, Oliver, Labuschagne, Christiaan Fred, Athineos, Dimitris, Van Den Broek, Niels, Mackay, Gillian M., Gottlieb, Eyal +4 more·2016·Science Advances
Cited by (177)
Items 101–177 of 177
- Exertional Exhaustion (Post-Exertional Malaise, PEM) Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue SyndromeJames Nicholas Baraniuk · 2025 · International Journal of Molecular Sciences
- More than a powerplant: the influence of mitochondrial transfer on the epigenomeAlexander Nikolich Patananan, Alexander J. Sercel, Michael A. Teitell · 2017 · Current Opinion in Physiology
- Automated profiling of gene function during embryonic developmentRebecca A. Green, Renat N. Khaliullin, Zhiling Zhao, Stacy D. Ochoa, Jeffrey M. Hendel, Tiffany-Lynn Chow, HongKee Moon, Ronald J. Biggs, Arshad B. Desai, Karen Oegema · 2024 · Cell
- Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathyWeisheng Xu, Qingqing Wang, Yongfei Yang, Shiyu Sun, Qi Hui, Jiantao He, Tong Jin, Ping Yao, Jiying Wang, Fuqing Lin · 2025 · Journal of Endocrinological Investigation
- Impact of Formate Supplementation on Body Weight and Plasma Amino AcidsSandeep Dhayade, Matthias Pietzke, Robert Wiesheu, Jacqueline Tait-Mulder, Dimitris Athineos, David P. Sumpton, Seth B. Coffelt, Karen Blyth, Alexei Vázquez · 2020 · Nutrients
- Metabolomics analysis reveals dysregulation in one carbon metabolism in Friedreich AtaxiaThomas M. O’Connell, David L. Logsdon, Ronald Mark Payne · 2022 · Molecular Genetics and Metabolism
- Unconventional rectifying interface of bimetal/carbon catalyst act as charge emitter for efficiently bending * CO 2 to stably drive the formation of formateYangyang Zhang, Yanxu Chen, Yifan Li, Mingyu Cheng, Ping Yan, Xin‐Yao Yu, Genqiang Zhang · 2025 · InfoMat
- A dynamic EFM-based model for antibody producing cell lines and model based evaluation of fed-batch processesDenizhan Yilmaz, Satish J. Parulekar, Ali Çınar · 2020 · Biochemical Engineering Journal
- Proteome overabundance enables respiration but limitation onsets carbon overflowRahul Kumar, Aleksandr Illarionov, Petri‐Jaan Lahtvee · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Metabolic markers detect early ostedifferentiation of mesenchymal stem cells from multiple donorsDaniela S. C. Bispo, Inês C. R. Graça, Catarina S. H. Jesus, João E. Rodrigues, Marlene Correia, Sabrina Atella, Iola F. Duarte, Brian James Goodfellow, Mariana B. Oliveira, João Filipe Mano et al. · 2025 · Stem Cell Research & Therapy
- Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine BKarel Vališ, Valéria Grobárová, Lucie Hernychová, Martina Bugáňová, Daniel Kavan, Martin Kalous, Jiří Černý, Eva Stodůlková, Marek Kuzma, Miroslav Flieger et al. · 2017 · Oncotarget
- ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreasMarc Hennequart, Loïc Mervant, Julie Stockis, Jack Coomes, Martha M. Zarou, Louise Gerard, Virginie Tevel, Valérie Migeot, Steven E. Pilley, Younghwan Lee et al. · 2026 · Nature Metabolism
- Deuterium MRI of serine metabolism in mouse models of glioblastomaFriederike Hesse, Jacob C.M. Low, Jianbo Cao, Flaviu Bulat, Felix Kreis, Alan J. Wright, Kevin Michael Brindle · 2024 · Magnetic Resonance in Medicine
- Cerebrospinal fluid metabolomics, lipidomics and serine pathway dysfunction in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS)James Nicholas Baraniuk · 2025 · Scientific Reports
- Formate and its role in amino acid metabolismJohn T. Brosnan, Margaret E. Brosnan · 2019 · Current Opinion in Clinical Nutrition & Metabolic Care
- Serine metabolism contributes to cell survival by regulating extracellular pH and providing an energy source in Saccharomyces cerevisiaeArisa Kawamukai, Ayana Iwano, Momoka Shibata, Yuko Kishi, Akira Matsuura · 2023 · Yeast
- Different photorespiratory mechanisms in conifer leaves, where peroxisomes have intrinsically low catalase activityShin‐Ichi Miyazawa, Tokuko Ujino‐Ihara, Takafumi Miyama, Ko Tahara, Hiroyuki Tobita, Yuji Suzuki, Mitsuru Nishiguchi · 2023 · The Plant Journal
- Mitochondrial respiration supports cancer growth independent of OXPHOSChristos Chinopoulos · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodJunhui Li, Jie Jiang, Yi Zhu, Yu Zhang, Jiang Zhu, Yingzi Ming · 2024 · Parasites & Vectors
- Bioprocess biomarker identification and diagnosis for industrial mAb production based on metabolic profiling and multivariate data analysisYingting Shi, Yuxiang Wan, Jiayu Yang, Yuting Lu, Xinyuan Xie, Jianyang Pan, Haibin Wang, Haibin Qu · 2025 · Bioprocess and Biosystems Engineering
- Oncogenic Ras expression increases cellular formate productionTheerawat Pongnopparat, Garrett Tingley, Yuzhen Gao, John T. Brosnan, Margaret E. Brosnan, Sherri L. Christian · 2021 · Amino Acids
- Metabolic adaptation to consume butyrate under prolonged resource exhaustionSophia Katz, Claudia Grajeda‐Iglesias, Bella Agranovich, Alia Ghrayeb, Ifat Abramovich, Sabrin Hilau, Eyal Gottlieb, Ruth Hershberg · 2023 · PLoS Genetics
- A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular OrganizationFilipa Lopes‐Coelho, Filipa Martins, Ana Hipólito, Sílvia V. Conde, Sofia Azeredo Pereira, Luís G. Gonçalves, Jacinta Serpa · 2022 · Biomedicines
- Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergerianaDahye Yoon, Seon Min Oh, Hyeon Seon Na, Boram Choi, Kwan-Woo Kim, Young‐Seob Lee, Dong‐Ryung Lee, Dae‐Young Lee · 2024 · Scientific Reports
- Two effective models based on comprehensive lipidomics and metabolomics can distinguish BC versus HCs, and TNBC versus non‐TNBCJin Hui Yu, Shuoqing Fan, Wenna Jiang, Jingya Zhang, Lexin Yang, Jiawei Xiao, Haohua An, Li Ren · 2022 · PROTEOMICS - CLINICAL APPLICATIONS
- Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activityJoanna L. Fiddler, Jamie Blum, Katarina E. Heyden, Luisa F. Castillo, Anna Elizabeth Thalacker‐Mercer, Martha S. Field · 2023 · Genes & Nutrition
- Pathological role of methionine in the initiation and progression of biliary atresiaZheng Jiachen, Paul Kwong Hang Tam, Wong Kenneth Kak Yuen, Lui Vincent Chi Hang · 2023 · Frontiers in Pediatrics
- A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibitionAmit Subedi, Makoto Muroi, Yushi Futamura, Tatsuro Kawamura, Harumi Aono, Mayuko Nishi, Akihide Ryo, Nobumoto Watanabe, Hiroyuki Osada · 2019 · FEBS Letters
- Mitochondria and Tumor Metabolic Flexibility: Mechanisms and Therapeutic PerspectivesAmandine M.F. Rovini, Kareem A. Heslop, Eduardo N. Maldonado · 2021 · Elsevier eBooks
- Primary Metabolism co-Opted for Defensive Chemical Production in the Carabid Beetle, Harpalus pensylvanicusAdam M. Rork, Sihang Xu, Athula B. Attygalle, Tanya Renner · 2021 · Journal of Chemical Ecology
- Oxygen dependent mitochondrial formate production and the reverse Pasteur effectJohannes Meiser, Alexei Vázquez · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transportXiaojian Shi, Bryn Marie Reinstadler, Hardik Shah, Tsz‐Leung To, Katie Byrne, Luanna C. Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi Krishna Mootha et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5Haley Garbus, Obialunanma V. Ebenebe, Raihan Kabir, Mark Jeffrey Kohr · 2025 · FASEB BioAdvances
- Screening of postoperative adjuvant chemotherapy-related serum metabolic markers in breast cancer patients based on 1H NMR metabonomicsRanran Hou, Wenbin Huang, Yu‐Feng Lin, Weiping Li, Jianwei Dong, Xinping Huang, Man Xu, Qian Li, Yongcheng Zhang, Yongxia Yang · 2024 · Translational Cancer Research
- A toxin that fuels metabolismXiaojing Liu, Jason W. Locasale · 2017 · Nature
- The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetlesAdam M. Rork, Sihang Xu, Athula B. Attygalle, Tanya Renner · 2025 · Insect Molecular Biology
- A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine DeficiencyMichael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard M. Reisdorph, Cole R. Michel, Katrina Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong et al. · 2026 · Journal of Inherited Metabolic Disease
- The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic SignificanceYuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou · 2026 · MedComm – Oncology
- Precise Targeting One‐Carbon Metabolism for Potent Cancer Therapy and Metastasis SuppressionQingping Feng, Wenting Zhang, Yinghua Peng, Chuanqi Zhao, Jinsong Ren, Xiaogang Qu · 2025 · Small
- DJ1 at the interface between neuro-degeneration and cancerJohannes Meiser, Alexei Vázquez, Karsten Hiller · 2017 · Oncotarget
- Computational metabolic modeling unveils gut microbiome’s role in metabolic shifts during murine cancer cachexiaTorben Kuehnast, Isabella Pototschnig, Manuela Träger, Christian Diener, Hansjörg Habisch, Andrea Vogel, Lisa Wink, Alexander Mahnert, Tobias Madl, Thomas Weichhart et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- De Novo Acetate Production is Coupled to Central Carbon Metabolism in MammalsXiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale · 2018 · SSRN Electronic Journal
- Comparative metabolic profiling by 1H-NMR spectroscopy analysis reveals the adaptation of S. mansoni from its host to in vitro culture conditions: a pilot study with ex vivo and GSH-supplemented medium-cultured parasitesValentina Fustaino, Roberto Gimmelli, Alessandra Guidi, Sara Lentini, Fulvio Saccoccia, Greta Petrella, Daniel Oscar Cicero, Giovina Ruberti · 2022 · Parasitology Research
- Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activityJoanna L. Fiddler, Jamie Blum, Luisa F. Castillo, Anna Elizabeth Thalacker‐Mercer, Martha S. Field · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.Micah A. Luftig · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gutBjörn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel Joseph Windross, Laura Neises, Neha Mishra et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Population level genetic memory of prior metabolic adaptation in E. coliSophia Katz, Claudia Grajeda‐Iglesias, Bella Agranovich, Alia Ghrayeb, Ifat Abramovich, Sabrin Hilau, Eyal Gottlieb, Ruth Hershberg · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensingMartha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Amy Dawson, Angela Ianniciello, Karen M. Dunn, Mhairi Copland, David P. Sumpton, Alexei Vázquez, G. Vignir Helgason · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix MetalloproteinasesCatherine Delbrouck, Nicole Kiweler, Vitaly Igorevich Pozdeev, Laura Neises, Anaïs Oudin, Anne M. Schuster, Aymeric Fouquier d’Hérouël, Ruolin Shen, Rashi Halder, Antoine Lesur et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcriptomic Analysis of Genes Associated with Nucleic Acid and Histone Methylation and One-Carbon Metabolism in a Mouse Cone Photoreceptor-Derived Cell Line Treated with 7-Dehydrocholesterol-Derived OxysterolsBruce A. Pfeffer, Steven J. Fliesler · 2024 · Essentials in ophthalmology/Essentials ophthalmology
- D-lactate enhances inflammatory and cytotoxic functions of Th1 cells through stereospecific control of mitochondrial ROSAdrian Madrigal-Avilés, Valerie Plajer, Paulo R. Viana Mendonca, Sebastian Serve, Leticia Soriano‐Baguet, Dirk Brenner, Maria R. Dzamukova, Mir‐Farzin Mashreghi, Max Löhning · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- SLFN11 Loss-Induced Chemoresistance is Associated with Overexpression of Glycerophospholipid Biosynthesis in Ewing SarcomaKasturee Chakraborty, Ritambhar Burman, Saharsh Satheesh, Matthew Kieffer, Chandni Karuhatty, Zuo‐Fei Yuan, Haiyan Tan, Ankhbayar Lkhagva, Anthony A. High, Xusheng Wang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Creatine synthesis is a tumor suppressor pathway hypostatic to one-carbon metabolismNicole Yong Ting Leung, Tiffany Melanie Yee, Roya AminiTabrizi, Ragini Bhalla, Nicholas Ang, Liangjian Lu, Chang‐Yien Chan, Derrick Wen Quan Lian, Matthew Y. Lim, João A. Paulo et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 3 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cellsTheresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak et al. · 2024 · Figshare
- Additional file 7 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 3 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 1 of Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activityJoanna L. Fiddler, Jamie Blum, Katarina E. Heyden, Luisa F. Castillo, Anna Elizabeth Thalacker‐Mercer, Martha S. Field · 2023 · Figshare
- Additional file 1 of Identification of characteristic metabolic panels for different stages of prostate cancer by 1H NMR-based metabolomics analysisZhang, Xi, Xia, Binbin, Zheng, Hong, Ning, Jie, Zhu, Yinjie, Shao, Xiaoguang, Binrui Liu, Baijun Dong, Gao, Hongchang · 2022 · Figshare
- Additional file 5 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 2 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cellsTheresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak et al. · 2024 · Figshare
- Additional file 4 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 1 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 6 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 4 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cellsTheresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak et al. · 2024 · Figshare
- Additional file 2 of Metabolomics analysis of patients with Schistosoma japonicum infection based on UPLC-MS methodLi, Junhui, Jiang, Jie, Yi Zhu, Zhang, Yu, Zhu, Jiang, Ming, Yingzi · 2024 · Figshare
- Additional file 1 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cellsTheresa Haitzmann, Katharina Schindlmaier, Tobias Frech, Ayusi Mondal, Visnja Bubalo, Barbara Konrad, Gabriele Bluemel, Philipp Stiegler, Stefanie Lackner, Andelko Hrzenjak et al. · 2024 · Figshare
- Local Glutamate-Glutamine Cycling Underlies Presynaptic ATP HomeostasisReinoud Maex · 2026 · Neural Computation
- Formate reduces ischemic injury in the male heart by increasing protein S -nitrosationHaley Garbus, Raihan Kabir, Obialunanma V. Ebenebe, Priyanka Patel, Deepthi Ashok, Diego Quiroga, Samarjit Das, Brian P O'Rourke, Mark J. Crabtree, Mark Jeffrey Kohr · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Serine Hydroxymethyltransferase in Cancer CellsЛ. А. Гаврилюк · 2025 · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
- Identification of biomarkers for non-invasive diagnosis and risk stratification in prostate cancer using NMR-based metabolomics and machine learningXi Zhang, Minjiang Chen, Binbin Xia, Binrui Liu, Xiaoya Lin, Hanyang Tao, He Wang, Tengfei Gu, Jie Li, Baijun Dong et al. · 2026 · npj Precision Oncology
- Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targetingJia-Ying Li, Xueqing Zhang, Rui Sheng · 2026 · Journal of Translational Medicine
- Emerging concepts on one-carbon metabolism as a unique and actionable vulnerability in cancerMathew Joseph Schneider, Zhanjun Hou, Larry H. Matherly · 2026 · ASPET Discovery
- Serine determines tissue targeted efficacy of PKM2 modulators in atopic dermatitisLuke A.J. O'Neill, Tom Ashton, Sabine Broc, Gareth Davies, Martin Domville, Marina Makrecka‐Kuka, Hamel Patel, Angharad E. Fenton-May, Neil J. Bennett, Kimberly Herman et al. · 2026 · Research Square
- Serine: From Metabolic Intermediate to Signaling EntitySharon Spizzichino, Giovanni Maria Varchetta, Giulia Elizabeth Borsatti, Emma Chillemi, Marzia Arese, Alessio Paone, Serena Rinaldo, Francesca Cutruzzolà · 2026 · Biochemistry
- Formate reduces cardiac ischemia-reperfusion injury in murine ex vivo and in vitro modelsHaley Garbus, Raihan Kabir, Obialunanma V. Ebenebe, Priyanka Patel, Deepthi Ashok, Diego Quiroga, Samarjit Das, Brian P O'Rourke, Mark J. Crabtree, Mark Jeffrey Kohr · 2026 · American Journal of Physiology-Heart and Circulatory Physiology
- Targeting the Selectivity Barrier in One-Carbon Metabolism: Rutaecarpine Preferentially Inhibits MTHFD2 over MTHFD1Fanourios Andreou, Christos C. Petrou, Christos P. Papaneophytou · 2026 · Applied Sciences
- Beyond classical overflow metabolism: Toward a unified mechanistic frameworkGuangxue Wu, Fengxia Sun, Tingxia Liu, Samira Ranjbar, Ezgi Tanıl, Bang Du · 2026 · Bioresource Technology