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Cited by 170Pancreatic function and diabetesHydrogels: synthesis, properties, applicationsTissue Engineering and Regenerative Medicine

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

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Weaver, Jessica D., Headen, Devon M., Aquart, Jahizreal, Johnson, Christopher T., Shea, Lonnie D., Shirwan, Haval, García, Andrés J.·2017·Science Advances
DOI 10.1126/sciadv.1700184PMC PMC5457148
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Abstract

VEGF-delivering synthetic hydrogel improves islet survival and function in extrahepatic transplant sites over current clinical method.

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  • Incorporating VEGF-releasing capsules into a pre-vascularization strategy or transplanting islets within VEGF-releasing hydrogels further improved vessel formation.

    “Incorporating vascular endothelial growth factor (VEGF)-releasing capsules into a similar pre-vascularization strategy152 or transplanting islets within VEGF-releasing hydrogels153 were shown to further improve vessel formation.”

    From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [153]

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References 56 · Cited by 170

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Authors
Weaver, J. D., Headen, D. M., Aquart, J., Johnson, C. T., Shea, L. D., Shirwan, H., & García, A. J.
Affiliations
  • Georgia Institute of Technology (US)
  • Northwestern University (US)
  • University of Louisville (US)
  • Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2017-06-02
Volume
3
Issue
6
Pages
e1700184-e1700184
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.1700184
PMC
PMC5457148
OpenAlex
W2620833969
Cited by
170
References
56
Citations by year
2026: 8 · 2025: 13 · 2024: 20 · 2023: 19 · 2022: 11 · 2021: 22 · 2020: 28 · 2019: 22 · 2018: 26 · 2017: 1
FWCI
21.58
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Juvenile Diabetes Research Foundation International (ID0EUQAI18312, 2-SRA-2014-287-Q-R)
  • National Institute of Diabetes and Digestive and Kidney Diseases (ID0ENWAI18313, T90-DK097787)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (ID0EB3AI18314, F30AR069472)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
islet transplantation, type 1 diabetes, epididymal adipose tissue, in situ gelation, vascularization, engraftment, graft survival, inflammation
MeSH terms
Biocompatible Materials, Cell Survival, Islets of Langerhans, Leukocytes, Islets of Langerhans Transplantation, Neovascularization, Physiologic, Hydrogels, Vascular Endothelial Growth Factor A

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