Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

Cited by (227)

Items 201–227 of 227

1. Rational drug design for Alzheimer’s disease: from approved therapies to next-generation clinical candidates and AI-guided innovation
   Sana Saffour, Turgut Seçkin Gül, Halise Inci Gul · 2026 · Future Medicinal Chemistry
2. Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation
   Tai Young Kim, Mridula Bhalla, Uiyeol Park, Seung Jae Hyeon, In‐Young Hwang, Youngsuk Seo, Wongu Youn, Jin-A Lee, Jung-Hee Lee, Boyoung Lee et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
3. Controlling Epileptic Activity by Modulating Putrescine Metabolism
   Saif Qahtan, Zsolt Kovács, Enikő Rauch, Pál Tamás Szabó, László Héja · 2026 · Biomolecules
4. Dynamic contributions of astrocytes in Alzheimer’s disease
   Fang Guo, Ting Li, Xi‐Biao He · 2026 · Experimental Neurology
5. Integration of network pharmacology, structure-based pharmacophore modeling, DFT, molecular docking, and molecular dynamics simulations to identify multi-target small molecule inhibitors against Alzheimer’s disease
   Daniel Ocha Onwu, Rademene Sunday Oria, Yemi Adekola Adekunle, Moses Dele Adams, Onuabuchi Nnenna Ani, Adele Habiganuchi, Terhide Samuel Tyohemba, Ejovi Osioma, Biodun Mayowa Popoola, Oluwafemi Shittu Bakare et al. · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
6. Astrocytic GABAergic signaling in perioperative neurocognitive disorders: mechanisms and intervention strategies
   Ting Tang, X Wang, 黄惠娟, JianZhi Shi, Hua Zhang · 2026 · Frontiers in Neuroscience
7. Lacticaseibacillus rhamnosus KF7 ameliorates cognition impairments via prolactin signaling modulation in senescence mice induced by D-galactose
   Xiao-Hua Wang, Ming-Jie Li, Huayue Zhang, Danqi Wang, Dan Hu, Liu Zhen-min, Zheng-Jun Wu · 2026 · Food Science and Human Wellness
8. Astrocyte Structure–Function Relationship in Senescence and Neurodegeneration
   Daria V. Serebryanaya, Ksenia A. Kolgaeva, German A. Dya, Ivan M. Ermakov, Vsevolod Vadimovich Belousov · 2026 · Biochemistry (Moscow)
9. K34 (3,3″-Dihydroxy-6′-desmethyl Terphenyllin) Promotes Hemoglobin-Supported H2O2 Decomposition and Attenuates Neurodegenerative Phenotypes in APP/PS1 Mice with Focal GiD
   Yongmin Mason Park, Byeoung-Kyu Choi, Mingu Gordon Park, Myeongju Kim, Woojin Won, Hee Jae Shin, Changjoon Justin Lee · 2026 · Antioxidants
10. Enzyme−Targeted Therapeutics for Neurological Disorders
    Leonardo Massignan, Kanduru Lokesh, Sara Ziadat, David Uehling, Donald Fredric Weaver, Mark A. Reed · 2026 · Journal of Medicinal Chemistry
11. Astrocytic LCN2 contributes to neuroinflammation-associated cognitive impairment through dual disruption of excitatory/inhibitory balance
    Qiu-li He, Xiao-yi Hu, Yong-li Deng, Hai-peng Wu, Shu-yao Zhu, Hanwen Gu, Jian-jun Yang, Mu‐Huo Ji · 2026 · Brain Behavior and Immunity
12. Design, synthesis, and biological activity studies of novel iron-chelating hybrids targeting pathological pathways associated with Alzheimer's disease
    Camille Nguyen, Firas El Kadiry, Quentin Muziot, Marc Maresca, Cédric Spitz, Sylvia Pietri · 2026 · European Journal of Medicinal Chemistry Reports
13. BindingDB Entry 50023654: Network-Based Drug Optimization toward the Treatment of Parkinson's Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation.
    BindingDB · 2026 · UC San Diego
14. BindingDB Entry 50008221: Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.
    BindingDB · 2021 · UC San Diego
15. BindingDB Entry 50015793: Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles.
    BindingDB · 2023 · UC San Diego
16. BindingDB Entry 50007389: Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.
    BindingDB · 2021 · UC San Diego
17. BindingDB Entry 50018373: A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review.
    BindingDB · 2024 · UC San Diego
18. BindingDB Entry 50020469: Superiority of the Triple-Acting 5-HT
    BindingDB · 2024 · UC San Diego
19. BindingDB Entry 50021815: Discovery of novel benzimidazole derivatives as selective and reversible monoamine oxidase B inhibitors for Parkinson's disease treatment.
    BindingDB · 2025 · UC San Diego
20. BindingDB Entry 50019901: A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement.
    BindingDB · 2024 · UC San Diego
21. BindingDB Entry 50015382: Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
    BindingDB · 2023 · UC San Diego
22. BindingDB Entry 50013507: Mapping Chromone-3-Phenylcarboxamide Pharmacophore:
    BindingDB · 2022 · UC San Diego
23. BindingDB Entry 50012336: Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.
    BindingDB · 2022 · UC San Diego
24. BindingDB Entry 50012304: A dual-acting 5-HT
    BindingDB · 2022 · UC San Diego
25. BindingDB Entry 50017784: Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines.
    BindingDB · 2023 · UC San Diego
26. BindingDB Entry 50019293: Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors.
    BindingDB · 2024 · UC San Diego
27. BindingDB Entry 50012337: Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties.
    BindingDB · 2022 · UC San Diego