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Cited by 48Ultrasound Imaging and ElastographyAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

Imaging localized neuronal activity at fast time scales through biomechanics

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Patz, Samuel, Fovargue, Daniel, Schregel, Katharina, Nazari, Navid, Palotai, Miklos, Barbone, Paul E., Fabry, Ben, Hammers, Alexander +4 more·2019·Science Advances
DOI 10.1126/sciadv.aav3816PMC PMC6469937
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Abstract

Noninvasive measurement of fast neuronal activity, based on tissue stiffness maps from MRI elastography, is presented.

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Crossref · 10.1126/sciadv.aav3816

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  • Preclinical work suggests that some biomechanical changes occur faster than BOLD responses, in a similar way to DfMRI.

    “Preclinical work suggests that some biomechanical changes occur faster than BOLD responses, in a similar way to DfMRI (Nunes et al., 2021; Patz et al., 2019; Tsurugizawa et al., 2013).”

    From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Patz et al., 2019

    The Results and Discussion report stiffness changes at stimulus-switching frequencies where the slower BOLD response cannot follow, supporting the claim about faster biomechanical changes. The passages do not compare those changes with DfMRI, so that part is not supported by this source. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Patz, S., Fovargue, D., Schregel, K., Nazari, N., Palotai, M., Barbone, P. E., Fabry, B., Hammers, A., Holm, S., Kozerke, S., Nordsletten, D., & Sinkus, R.
Affiliations
  • Brigham and Women's Hospital (US)
  • King's College London (GB)
  • Boston University (US)
  • Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA.
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University of Oslo (NO)
  • University of Zurich (CH)
  • Inserm (FR)
Corresponding author
  • Patz, Samuel
  • Sinkus, Ralph
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-04-05
Volume
5
Issue
4
Pages
eaav3816-eaav3816
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aav3816
PMC
PMC6469937
OpenAlex
W2938713030
Cited by
48
References
2
Citations by year
2026: 4 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 3 · 2017: 1
FWCI
4.30
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science Advances (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • HAL (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by-nc)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by-nc)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • ETH Zürich Research Collection
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • National Institutes of Health (R21EB030757)
  • Wellcome Trust (WT 203148/Z/16/Z)
  • Brigham and Women’s Hospital
  • Boston University
  • Horizon 2020 Framework Programme (668039)
  • Seventh Framework Programme (FP7/20072013)
  • Deutsche Forschungsgemeinschaft (SCHR 1542/1-1)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
brain biomechanics, magnetic resonance elastography, brain stiffness, electrical stimulation, thalamus, stimulus frequency dependence
MeSH terms
Acoustic Stimulation, Animals, Brain, Brain Mapping, Electric Stimulation, Forelimb, Hindlimb, Magnetic Resonance Imaging, Mice, Inbred C57BL, Thalamus, Mice

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