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Cited by 140Pain Mechanisms and TreatmentsIon Channels and ReceptorsTactile and Sensory Interactions

An ultrafast system for signaling mechanical pain in human skin

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Nagi, Saad S., Marshall, Andrew G., Makdani, Adarsh, Jarocka, Ewa, Liljencrantz, Jaquette, Ridderström, Mikael, Shaikh, Sumaiya, O’Neill, Francis +11 more·2019·Science Advances
DOI 10.1126/sciadv.aaw1297PMC PMC6609212
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Abstract

Pain can be signaled as fast as touch in human peripheral nerves.

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  • For the foot dorsum and leg, our sample included 315 afferents, 47% of which were slowly adapting.

    “For the foot dorsum and leg, our sample included 315 afferents, 47% of which were slowly adapting (Aimonetti et al. 2007;Edin 2001;Nagi et al. 2019;Ribot-Ciscar et al. 1996, 1989;Trulsson 2001).”

    From Tactile innervation densities across the whole body (2020) · cites this paper as Nagi et al. 2019

    The Results report 129 peroneal afferents and identify slowly adapting SA1 and SA2 afferents, so this paper could contribute observations to the citing authors’ combined sample. It does not report the combined total of 315 foot-dorsum and leg afferents or establish that 47% of that sample were slowly adapting. (LLM, conf=0.86)

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Authors
Nagi, S. S., Marshall, A. G., Makdani, A., Jarocka, E., Liljencrantz, J., Ridderström, M., Shaikh, S., O’Neill, F., Saade, D., Donkervoort, S., Foley, A. R., Minde, J., Trulsson, M., Cole, J., Bönnemann, C. G., Chesler, A. T., Bushnell, M. C., McGlone, F., & Olausson, H.
Affiliations
  • Linköping University (SE)
  • University of Manchester (GB)
  • Liverpool John Moores University (GB)
  • Umeå University (SE)
  • National Institutes of Health (US)
  • University Hospital of Umeå (SE)
  • University of Liverpool (GB)
  • Karolinska Institutet (SE)
  • Bournemouth University (GB)
Corresponding author
  • Nagi, Saad S.
  • Marshall, Andrew G.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-07-05
Volume
5
Issue
7
Pages
eaaw1297-eaaw1297
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aaw1297
PMC
PMC6609212
OpenAlex
W2955273669
Cited by
140
References
2
Citations by year
2026: 17 · 2025: 21 · 2024: 21 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 21 · 2019: 1
FWCI
11.32
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Bournemouth University Research Online (Bournemouth University) (acceptedVersion)
  • Liverpool John Moores University (acceptedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders
  • Pain Relief Foundation
  • Swedish Research Council Formas
  • NINDS
  • ALF Region Östergötland
  • Intramural Research Program of the NIH, specifically the NCCIH
  • DDIR Innovation Award
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords
mechanical pain, high-threshold mechanoreceptors, conduction velocity, Piezo2, mechanotransduction, pain perception, cutaneous afferents, microneurography
MeSH terms
Loss of Function Mutation, Adult, Aged, Aged, 80 and over, Axons, Electric Stimulation, Female, Humans, Ion Channels, Male, Mechanoreceptors, Middle Aged, Nerve Fibers, Myelinated, Neurons, Afferent, Hereditary Sensory and Autonomic Neuropathies, Neurophysiology, Nociceptors, Pain, Skin, Signal Transduction, Mechanotransduction, Cellular, Young Adult

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