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Cited by 35T-cell and B-cell ImmunologyMicroRNA in disease regulationPsoriasis: Treatment and Pathogenesis

MiR-23~27~24–mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation

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Wu, Cheng-Jang, Cho, Sunglim, Huang, Hsi-Yuan, Lu, Chun-Hao, Russ, Jasmin, Cruz, Leilani O., da Cunha, Flavia Franco, Chen, Mei-Chi +13 more·2019·Science Advances
DOI 10.1126/sciadv.aaw1715PMC PMC6905868
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Abstract

miR-23~27~24 regulates T FH cells through targeting multiple genes including TOX, a key transcription factor for T FH cell biology.

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  • The miR-23-27-24 cluster coordinates control of follicular helper T cells by targeting essential gene networks, thereby promoting humoral immunity.

    “Follicular helper T cells are crucial for the generation of protective humoral immunity, and the miR-23-27-24 cluster coordinates the control of follicular helper T cells by targeting essential gene networks, thereby promoting humoral immunity [27].”

    From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [27]

    The Results section confirms that the miR-23~27~24 family cooperatively targets genes involved in follicular helper T-cell differentiation. But it reports the opposite direction of effect: deleting the family increased follicular helper T-cell responses and virus-specific antibodies, while overexpressing it diminished follicular helper T-cell and germinal-center B-cell responses. The claim that the cluster thereby promotes humoral immunity is contrary to these findings (page unavailable in our copy). (LLM, conf=0.90)

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References 43 · Cited by 35

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Authors
Wu, C.-J., Cho, S., Huang, H.-Y., Lu, C.-H., Russ, J., Cruz, L. O., da Cunha, F. F., Chen, M.-C., Lin, L.-L., Warner, L. M., Liao, H.-K., Utzschneider, D. T., Quon, S., Berner, J., Camara, N. O. S., Zehn, D., Belmonte, J. C. I., Chen, L.-C., Huang, S.-F., Kuo, M.-L., & Lu, L.-F.
Affiliations
  • University of California San Diego (US)
  • Chinese University of Hong Kong (HK)
  • Chang Gung University (TW)
  • Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Salk Institute for Biological Studies (US)
  • Technical University of Munich (DE)
  • Department of Nephrology, Federal University of Sao Paulo, Sao Paulo, Brazil.
  • Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Chang Gung Memorial Hospital (TW)
Corresponding author
Lu, Li-Fan
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-12-06
Volume
5
Issue
12
Pages
eaaw1715-eaaw1715
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aaw1715
PMC
PMC6905868
OpenAlex
W2994834355
Cited by
35
References
43
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 2 · 2018: 1
FWCI
1.80
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc)
  • mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
Funders
NIH Office of the Director (AI089935, AI103646, AI108651, AI123782)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
microRNA, TOX transcription factor, T follicular helper cells, T cell differentiation, humoral immunity, regulatory circuits, miRNA target genes
MeSH terms
Animals, Cell Differentiation, T-Lymphocytes, Helper-Inducer, High Mobility Group Proteins, Humans, Lymphocyte Activation, T-Lymphocytes, Signal Transduction, Gene Expression Regulation, Developmental, MicroRNAs, Mice, Proto-Oncogene Proteins c-bcl-6, Immunity, Humoral

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