New power of self-assembling carbonic anhydrase inhibitor: Short peptide–constructed nanofibers inspire hypoxic cancer therapy
Open accessAbstract
Self-assembly of CA inhibitor offers strategic therapy for hypoxic tumors, with marked selectivity and interesting mode of action.
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References 43 · Cited by 134
- Authors
- Li, J., Shi, K., Sabet, Z. F., Fu, W., Zhou, H., Xu, S., Liu, T., You, M., Cao, M., Xu, M., Cui, X., Hu, B., Liu, Y., & Chen, C.
- Affiliations
- National Center for Nanoscience and Technology (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Jiayang
- Shi, Kejian
- Sabet, Zeinab Farhadi
- Chen, Chunying
- ORCID
- Venue
- Science Advances
- Published
- 2019-09-06
- Volume
- 5
- Issue
- 9
- Pages
- eaax0937-eaax0937
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC6731069
- OpenAlex
- W2972305687
- Cited by
- 134
- References
- 43
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 14 · 2023: 19 · 2022: 31 · 2021: 25 · 2020: 20 · 2019: 1
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31571022, 31871004)
- National Basic Research Program of China (2016YFA0201600, 2016YFA0203204)
- The National Science Fund for Excellent Young Scholars (31622026)
- The National Science Fund for Distinguished Young Scholars (11425520)
- Science Fund for Creative Research Groups of the National Natural Science Foundation of China (11621505)
- CAS Key Research Program for Frontier Sciences (QYZDJ-SSW-SLH022)
- Key Program for International S&T Cooperation Projects of China (2016YFE0133100)
- Bureau of International Co-operation Chinese Academy of Sciences (GJHG1852)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- carbonic anhydrase IX, carbonic anhydrase inhibitors, tumor hypoxia, tumor acidosis, endocytosis, autophagy inhibition, breast cancer, doxorubicin combination therapy, angiogenesis inhibition, antimetastatic effect, targeted drug delivery
- MeSH terms
- Animals, Breast Neoplasms, Carbonic Anhydrase Inhibitors, Doxorubicin, Female, Humans, Mice, Nude, Peptides, Cell Hypoxia, Xenograft Model Antitumor Assays, Cell Line, Tumor, Mice, Nanofibers
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