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Cited by 38Esophageal Cancer Research and TreatmentHydrogels: synthesis, properties, applicationsGastroesophageal reflux and treatments

Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett’s esophagus

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Naranjo, Juan Diego, Saldin, Lindsey T., Sobieski, Eric, Quijano, Lina M., Hill, Ryan C., Chan, Patrick G., Torres, Crisanto, Dziki, Jenna L. +12 more·2020·Science Advances
DOI 10.1126/sciadv.aba4526PMC PMC7329334
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Abstract

Oral delivery of esophageal extracellular matrix hydrogel mitigates mucosal inflammation and metaplasia in a dog model of reflux.

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  • Esophageal matrix hydrogel shows a tissue-specific remodeling response in an esophageal cancer dog model, as opposed to a urinary bladder matrix hydrogel.

    “while esophageal matrix hydrogel has shown tissue-specific remodeling response in a esophageal cancer dog model, as opposed to an urinary bladder matrix hydrogel [154].”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [154]

    The Results section ('eECM hydrogel mitigates metaplastic change in the esophageal mucosa'; page unavailable) reports improvement in dogs with Barrett’s-type metaplasia after esophageal ECM hydrogel treatment. The study did not use an esophageal cancer model or compare the hydrogel with urinary bladder matrix hydrogel: its control dogs received omeprazole only, as stated in the Results section on macroscopic inflammation (page unavailable). Thus it does not establish the claimed tissue-specific response relative to urinary bladder matrix. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • ECM degradation peptides promote M2-like phenotypes in vitro and in vivo.

    “promotion of M2-like phenotypes in vitro [40,44,153] and in vivo [152,154,155].”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [154]

    The Discussion (page unavailable) says ECM degradation products promote a shift from proinflammatory macrophages toward a regulatory, anti-inflammatory phenotype in vitro and in vivo. The dog study found fewer TNFα-positive cells after eECM hydrogel treatment, but it did not isolate degradation peptides or establish an M2-like phenotype specifically. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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References 60 · Cited by 38

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Authors
Naranjo, J. D., Saldin, L. T., Sobieski, E., Quijano, L. M., Hill, R. C., Chan, P. G., Torres, C., Dziki, J. L., Cramer, M. C., Lee, Y. C., Das, R., Bajwa, A. K., Nossair, R., Klimak, M., Marchal, L., Patel, S., Velankar, S. S., Hansen, K. C., McGrath, K., & Badylak, S. F.
Affiliations
  • University of Pittsburgh (US)
  • University of Colorado Anschutz (US)
  • UPMC Health System (US)
Corresponding author
Badylak, Stephen F.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2020-07-03
Volume
6
Issue
27
Pages
eaba4526-eaba4526
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aba4526
PMC
PMC7329334
OpenAlex
W3040581353
Cited by
38
References
60
Citations by year
2026: 5 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 13 · 2021: 4 · 2020: 2
FWCI
5.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Science Advances (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Office of Naval Research (N00014-14-1-0723)
  • National Cancer Institute (F31CA210694)
  • Clinical and Translational Science Institute, University of Pittsburgh (UL1TR001857)
  • BARD
Topics
  • Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
Barrett's esophagus, extracellular matrix hydrogel, metaplasia, mucoadhesive hydrogels, inflammation, canine model, tissue engineering

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