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Cited by 73Pancreatic function and diabetesTissue Engineering and Regenerative MedicineDiabetes Management and Research

An inverse-breathing encapsulation system for cell delivery

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Wang, Long-Hai, Ernst, Alexander Ulrich, Flanders, James Arthur, Liu, Wanjun, Wang, Xi, Datta, Ashim K., Epel, Boris, Kotecha, Mrignayani +2 more·2021·Science Advances
DOI 10.1126/sciadv.abd5835PMC PMC8121434
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Abstract

A cell encapsulation system generates oxygen from carbon dioxide for self-oxygenation.

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  • In both oxygen-generating examples, the oxygen generated by the device significantly enhanced the viability and function of the islets after transplantation.

    “In both these examples, the oxygen generated by the device significantly enhanced the viability and function of the islets after transplantation.”

    From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [99]

  • Oxygen generating materials inserted alongside the islet graft improve oxygen levels at the transplantation site, and another strategy directly pumps oxygen into an encapsulation device.

    “To specifically improve oxygen levels at the transplantation site, oxygen generating materials have been inserted alongside the islet graft,96,98,99 while another strategy directly pumps oxygen into an encapsulation device92,97.”

    From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [99]

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References 61 · Cited by 73

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Authors
Wang, L.-H., Ernst, A. U., Flanders, J. A., Liu, W., Wang, X., Datta, A. K., Epel, B., Kotecha, M., Papas, K. K., & Ma, M.
Affiliations
  • Cornell University (US)
  • University of Chicago (US)
  • O2M Technologies LLC, Chicago, IL 60612, USA.
  • University of Arizona (US)
Corresponding author
Ma, Minglin
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-05-14
Volume
7
Issue
20
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abd5835
PMC
PMC8121434
OpenAlex
W3163890065
Cited by
73
References
61
Citations by year
2026: 5 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 18 · 2021: 5
FWCI
13.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • UA Campus Repository (The University of Arizona) (acceptedVersion, cc-by-nc)
  • Knowledge@UChicago (University of Chicago) (submittedVersion, cc-by-nc-nd)
  • University of Chicago
Funders
  • National Science Foundation (DGE-1650441, 1819583)
  • National Institutes of Health (1R01DK105967-01A1)
  • National Cancer Institute (R43CA224840, R44CA224840)
  • Small Business Innovation Research (R43CA224840, R44CA224840, 1819583)
  • JDRF (2-SRA-2018-472-S-B, 3-SRA-2020-883-M-B)
  • National Science Foundation Graduate Research Fellowship (DGE-1650441)
  • Juvenile Diabetes Research Foundation (3-SRA-2020-883-M-B, 2-SRA-2018-472-S-B)
  • Novo Nordisk Company
  • Hartwell Foundation
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
cell delivery, islet transplantation, hypoxic cell survival, normoglycemia, diabetes mellitus, subcutaneous implantation, device optimization, minipigs, diabetic mice

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