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Cited by 43Cellular transport and secretionLipid Membrane Structure and BehaviorCellular Mechanics and Interactions

Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals

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Gomis Perez, Carolina, Dudzinski, Natasha R., Rouches, Mason, Landajuela, Ane, Machta, Benjamin, Zenisek, David, Karatekin, Erdem·2022·Science Advances
DOI 10.1126/sciadv.abl4411PMC PMC11580022
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Abstract

Cell membranes flow very differently across cell types, likely reflecting distinct membrane recycling activities.

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Crossref · 10.1126/sciadv.abl4411

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  • A reduction in membrane tension after exocytosis cannot account for the kinetics and spatial precision of ultrafast endocytosis.

    “Therefore, even if membrane tension alters upon exocytosis, this model cannot account for the kinetics and spatial precision of ultrafast endocytosis.”

    From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [11]

    The Introduction says slowly propagating tension could not trigger rapid endocytosis, but presents that as a problem the study investigates, not its conclusion. The Discussion instead says fast equilibration of membrane tension in presynaptic terminals likely contributes to coupling exocytosis and endocytosis. The paper does not establish that this mechanism cannot account for ultrafast endocytosis’s kinetics or spatial precision. (LLM, conf=0.86)

    Checked by a reasoning model — may be wrong.

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  • Membrane tension in neurons propagates at ~20 μm/s and is expected to equilibrate at the active zone within 10 ms of exocytosis, well before endocytic pit formation.

    “However, membrane tension in neurons seems to propagate at ~20 µm/s11, and therefore, is expected to equilibrate at the active zone within 10 ms of exocytosis, well before endocytic pit formation.”

    From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [11]

    The Results (‘Membrane tension dynamics are very different in retinal bipolar neurons and adrenal chromaffin cells’; page unavailable) report that tension changes traveled 4–11 μm within at most a few seconds. This supports rapid propagation in the studied neuronal terminals, but the passages do not establish the cited ~20 μm/s speed. The 10-ms active-zone estimate is presented as the citing authors’ inference, not as a finding attributed to this source. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

  • Recent experiments showed that membrane tension equilibrates rapidly at presynaptic terminals.

    “Consistent with this notion, recent experiments showed that membrane tension equilibrates rapidly at presynaptic terminals11.”

    From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [11]

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References 65 · Cited by 43

Research works printed but not linked: 62

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Authors
Gomis Perez, C., Dudzinski, N. R., Rouches, M., Landajuela, A., Machta, B., Zenisek, D., & Karatekin, E.
Affiliations
  • Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA.
  • Yale University (US)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Dudzinski, Natasha R.
  • Karatekin, Erdem
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-01-07
Volume
8
Issue
1
Pages
eabl4411-eabl4411
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abl4411
PMC
PMC11580022
OpenAlex
W4205684651
Cited by
43
References
65
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 9 · 2022: 8
FWCI
5.08
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science Advances (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (R01EY032396, P30EY026878)
  • National Institute of Neurological Disorders and Stroke (R21NS112754, R01NS122388)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
membrane tension, presynaptic terminals, membrane flow, exocytosis, endocytosis, chromaffin cells, membrane recycling

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