Alzheimer’s disease: Ablating single master site abolishes tau hyperphosphorylation

Stefanoska, Kristie, Gajwani, Mehul, Tan, Amanda R. P., Ahel, Holly I., Asih, Prita R., Volkerling, Alexander, Poljak, Anne, Ittner, Arne·2022·Science Advances

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  14. Procoagulant Extracellular Vesicles Increase Neuronal Tau expression, Metabolism and Processing Through Tissue Factor and Protease Activated Receptor 2
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  15. Revealing the conformational landscape of tau P → L mutants in R23 tau macromolecule: A pathway to targeted therapeutic design
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  16. Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer’s disease
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  18. Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in C. elegans
    Man Pok Lu, Yi Rong, Jingyi Wang, Xiaochun Yu, Hongjiang Liu, Yingjie Wu, Minxing Zhang, Yining Chen, Yidong Li, Yuner Yan et al. · 2026 · Cells
  19. Targeting serine/threonine kinases: therapeutic innovations for neurodegenerative disorders
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  20. Modeling Alzheimer’s disease with brain organoids: mechanisms, applications, and future directions
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  21. Tau Protein in Alzheimer's Disease
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  23. Tau-Targeted PROTACs Degrade Pathology-Associated Tau and Improve Memory in Alzheimer’s Disease Models
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  26. A scalable human neuron model of Alzheimer’s disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction
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