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Cited by 118Nanoparticle-Based Drug DeliveryEpilepsy research and treatmentAdvanced Drug Delivery Systems

Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy

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Wu, Di, Fei, Fan, Zhang, Qi, Wang, Xia, Gong, Yiwei, Chen, Xiaojie, Zheng, Yuyi, Tan, Bei +5 more·2022·Science Advances
DOI 10.1126/sciadv.abm3381PMC PMC8754409
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Abstract

Long-term pharmacotherapy, serving as the main therapeutic approach for epilepsy prophylaxis, has suffered from limited efficacy and potential side effects because of the blood-brain barrier (BBB) and untimely medication. Here, we reported a nanoengineered drug delivery system for synergistic brain-targeting delivery and on-demand drug release of antiepileptic drugs (AEDs). The dopamine-pyrrole hybrid system can improve delivery efficiency through a combination of receptor-mediated transcytosis and BBB disruption–enabled transport induced by photothermal conversion of near-infrared light. Incorporation of polydopamine endowed the delivery system with enhanced conductivity and sensitivity, giving sustained (2 hours) and rapid (30 s) drug release in response to epileptiform discharges. Acute, continuous, and spontaneous seizure models validated that the delivery system could inhibit seizures upon epileptiform abnormalities, treated by one-fifth of the conventional dosage. Complemented with satisfactory biosafety results, this “smart” modality is promising to be an effective and safe strategy to improve the therapeutic index of AEDs for epilepsy.

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  • Electro-responsive dopamine-pyrrole hybrid system shows enhanced conductivity and sensitivity in acute, continuous, and spontaneous seizure models.

    “This system was smart for epilepsy pharmacotherapy, showing enhanced conductivity and sensitivity in various seizure models, including acute seizure, continuous seizure, and spontaneous seizure.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [215]

    The Introduction and in vitro Results report improved conductivity and sensitivity to electrical stimuli in the dopamine–pyrrole nanoparticles. The in vivo Results report antiseizure effects in acute, status-epilepticus, and spontaneous-seizure models, but do not show that conductivity or stimulus sensitivity was measured or enhanced in those models. Page numbers are not available in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Electro-responsive dopamine-pyrrole hybrid system improves delivery efficiency of anti-epileptic drugs by improving BBB crossing via receptor-mediated transcytosis and photothermal conversion of NIR.

    “an electro-responsive dopamine-pyrrole hybrid system that improved the delivery efficiency of anti-epileptic drugs by improving the cross of BBB via the combination of receptor-mediated transcytosis and photothermal conversion of NIR were reported.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [215]

  • Electro-responsive dopamine-pyrrole hybrid system realizes two hours sustained and 30 s rapid release of phenytoin and reduces drug dosage.

    “The authors realized two hours sustained and 30 s rapid release of phenytoin and reduced drug dosage.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [215]

  • Reduced transendothelial electrical resistance of cellular monolayer induced by irradiation recovers within 10 min.

    “The reduced transendothelial electrical resistance of cellular monolayer induced by irradiation could recover within 10 min.”

    From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [215]

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Cited by

Sorted by citations

Authors
Wu, D., Fei, F., Zhang, Q., Wang, X., Gong, Y., Chen, X., Zheng, Y., Tan, B., Xu, C., Xie, H., Fang, W., Chen, Z., & Wang, Y.
Affiliations
  • Zhejiang Chinese Medical University (CN)
  • Zhejiang University (CN)
  • Zhejiang Gongshang University (CN)
Corresponding author
  • Wu, Di
  • Fei, Fan
  • Chen, Zhong
  • Wang, Yi
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-01-14
Volume
8
Issue
2
Pages
eabm3381-eabm3381
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abm3381
PMC
PMC8754409
OpenAlex
W4206389675
Cited by
118
References
1
Citations by year
2026: 19 · 2025: 30 · 2024: 44 · 2023: 19 · 2022: 6
FWCI
6.19
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
epilepsy, antiepileptic drugs, on-demand drug release, blood-brain barrier, polydopamine, photothermal conversion, near-infrared light, receptor-mediated transcytosis, epileptiform discharges, brain-targeted delivery, seizure suppression, therapeutic index

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