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Calcium Entry Leads to Inactivation of Calcium Channel in Paramecium
Abstract
Under depolarizing voltage clamp of Paramecium an inward calcium current developed and subsequently relaxed within 10 milliseconds. The relaxation was substantially slowed when most of the extracellular calcium was replaced by either strontium or barium. Evidence is presented that the relaxation is not accounted for by a drop in electromotive force acting on calcium, or by activation of a delayed potassium current. Relaxation of the current must, therefore, result from an inactivation of the calcium channel. This inactivation persisted after a pulse, as manifested by a reduced calcium current during subsequent depolarization. Inactivation was retarded by procedures that reduce net entry of calcium, and was independent of membrane potential. The calcium channel undergoes inactivation as a consequence of calcium entry during depolarization. In this respect, inactivation of the calcium channel departs qualitatively from the behavior described in the Hodgkin-Huxley model of the sodium channel.
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Citations
Cited by
Sodium and calcium channels in bovine chromaffin cells
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014394 · Cited by 961
Eckert, R., & Chad, J. E. (1984) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(84)90009-9 · Cited by 608
Self-citationAn enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.
Chad, J. E., & Eckert, R. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016206 · Cited by 406
Self-citationBaylor, S. M., Chandler, W. K., & Marshall, M. W. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014959 · Cited by 329
Ca2+-dependent modulation of voltage-gated Ca2+ channels
Christel, C., & Lee, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.12.012 · Cited by 112
Metadata
- Authors
- Brehm, P., & Eckert, R.
- Venue
- Science
- Published
- 1978-12-15
- Volume
- 202
- Issue
- 4373
- Pages
- 1203-1206
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963552271
- Cited by
- 533
- References
- 0
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
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