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The Major Histocompatibility Complex of the Mouse
Abstract
Like physicists striving to develop a unified field theory, immunologists are attempting to bring order to the microcosmos of defense reactions. Indications are that one of the most important constants in this microcosmos is the major histocompatibility complex (MHC) of the species. A test of any interpretation of the MHC's role in immunity is how well it explains this system's polymorphism. One of the most crucial questions an MHC hypothesis must answer is: Why are there so many alleles at this complex?
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Cited by
The class II molecules of the human and murine major histocompatibility complex
KAUFMAN, J., AUFFRAY, C., KORMAN, A., SHACKELFORD, D., & STROMINGER, J. (1984) · Cell · doi:10.1016/0092-8674(84)90068-0 · Cited by 667
Shaw, S., Johnson, A. H., & Shearer, G. M. (1980) · The Journal of experimental medicine · doi:10.1084/jem.152.3.565 · Cited by 346
Weiss, E., Golden, L., Zakut, R., Mellor, A., Fahrner, K., Kvist, S., & Flavell, R. A. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01444.x · Cited by 274
Helmy, M., Li, J. U., Yan, X. F., Meade, R. K., Anderson, E., Chen, P. B., Czechanski, A. M., Di Domenico, T., Flint, J., Garrison, E., et al. (2026) · Cell Genomics · doi:10.1016/j.xgen.2025.101074 · Cited by 2
“28 In 2024, the first mouse telomere-to-telomere (T2T) assemblies contained the complete H2 locus for BL6 and CAST/EiJ, 29,30 but most other important H2 haplotypes remain incomplete.”
Metadata
- Authors
- Klein, J.
- Venue
- Science
- Published
- 1979-02-09
- Volume
- 203
- Issue
- 4380
- Pages
- 516-521
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084984946
- Cited by
- 416
- References
- 0
- FWCI
- 28.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Klein, J. (1979). The Major Histocompatibility Complex of the Mouse. Science. https://doi.org/10.1126/science.104386
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.