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Cited by 339

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Requirement of a Centrosomal Activity for Cell Cycle Progression Through G 1 into S Phase

Hinchcliffe, Edward H., Miller, Frederick J., Cham, Matthew, Khodjakov, Alexey, Sluder, Greenfield·2001·Science

Abstract

Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells) entered and completed mitosis. However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmitotic karyoplasts assembled a microtubule-organizing center containing γ-tubulin and pericentrin, but did not regenerate centrioles. These observations reveal the existence of an activity associated with core centrosomal structures—distinct from elements of the microtubule-organizing center—that is required for the somatic cell cycle to progress through G 1 into S phase. Once the cell is in S phase, these core structures are not needed for the G 2 -M phase transition.

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Crossref · 10.1126/science.1056866

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Metadata

Authors
Hinchcliffe, E. H., Miller, F. J., Cham, M., Khodjakov, A., & Sluder, G.
Venue
Science
Published
2001-02-23
Volume
291
Issue
5508
Pages
1547-1550
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2012532095
Cited by
339
References
1
FWCI
10.23
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Requirement of a Centrosomal Activity for Cell Cycle Progression Through G 1 into S Phase. https://app.cochat.ai/papers/10.1126/science.1056866
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Hinchcliffe, E. H., Miller, F. J., Cham, M., Khodjakov, A., & Sluder, G. (2001). Requirement of a Centrosomal Activity for Cell Cycle Progression Through G 1 into S Phase. Science. https://doi.org/10.1126/science.1056866

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.