The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit
Abstract
Initiation of translation at the correct position on messenger RNA is essential for accurate protein synthesis. In prokaryotes, this process requires three initiation factors: IF1, IF2, and IF3. Here we report the crystal structure of a complex of IF1 and the 30 S ribosomal subunit. Binding of IF1 occludes the ribosomal A site and flips out the functionally important bases A1492 and A1493 from helix 44 of 16 S RNA, burying them in pockets in IF1. The binding of IF1 causes long-range changes in the conformation of H44 and leads to movement of the domains of 30 S with respect to each other. The structure explains how localized changes at the ribosomal A site lead to global alterations in the conformation of the 30 S subunit.
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Cites
[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
Structure of the 30S ribosomal subunit
Wimberly, B. T., Brodersen, D. E., Clemons, W. M., Morgan-Warren, R. J., Carter, A. P., Vonrhein, C., Hartsch, T., & Ramakrishnan, V. (2000) · Nature · doi:10.1038/35030006 · Cited by 2,035
Self-citationSpecific protection of 16 S rRNA by translationalinitiation factors
Moazed, D., Samaha, R. R., Gualerzi, C., & Noller, H. F. (1995) · Journal of Molecular Biology · doi:10.1016/s0022-2836(95)80042-5 · Cited by 152
Cited by
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
Ogle, J. M., Brodersen, D. E., Clemons, W. M., Tarry, M. J., Carter, A. P., & Ramakrishnan, V. (2001) · Science · doi:10.1126/science.1060612 · Cited by 1,162
Self-citationRibosome Structure and the Mechanism of Translation
Ramakrishnan, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00619-0 · Cited by 938
Self-citationWhat recent ribosome structures have revealed about the mechanism of translation
Schmeing, T. M., & Ramakrishnan, V. (2009) · Nature · doi:10.1038/nature08403 · Cited by 699
Self-citationInitiation of Protein Synthesis in Bacteria
Laursen, B. S., Sørensen, H. P., Mortensen, K. K., & Sperling-Petersen, H. U. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.101-123.2005 · Cited by 616
The Molecular Mechanics of Eukaryotic Translation
Kapp, L. D., & Lorsch, J. R. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.030403.080419 · Cited by 538
Metadata
- Authors
- Carter, A. P., Clemons, W. M., Brodersen, D. E., Morgan-Warren, R. J., Hartsch, T., Wimberly, B. T., & Ramakrishnan, V.
- Venue
- Science
- Published
- 2001-01-19
- Volume
- 291
- Issue
- 5503
- Pages
- 498-501
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091336733
- Cited by
- 382
- References
- 3
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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