Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex
Abstract
The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of long-term CTA memory depends on muscarinic and beta-adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and beta-adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This resembles the molecular signature of the formation of long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with learning, but the mechanisms of learning anew differ from those of learning the new.
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Previous studies have mainly tested the inhibitory learning model using conditioning paradigms with rodents or human non-clinical samples.
“Notably, previous existing studies have mainly tested the inhibitory learning model using conditioning paradigms with rodents (e.g. Berman and Dudai, 2001; Cain et al., 2004; Harris and Westbrook, 1998; McNally, 2005), or human non-clinical samples (e.g. Eifert and Heffner, 2003; Karekla et al., 2004).”
From Feeling more confident to encounter negative emotions: The mediating role of distress tolerance on the relationship between self-efficacy and outcomes of exposure and response prevention for OCD (2024) · cites this paper as Berman and Dudai, 2001
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References 25 · Cited by 472
- Authors
- Berman, D. E., & Dudai, Y.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Dudai, Yadin
- ORCID
- Berman, Diego E.
- Venue
- Science
- Published
- 2001-03-23
- Volume
- 291
- Issue
- 5512
- Pages
- 2417-2419
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029469204
- Cited by
- 472
- References
- 25
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 6 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 12 · 2016: 24 · 2015: 15 · 2014: 22 · 2013: 19 · 2012: 20
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- conditioned taste aversion, memory extinction, insula, beta-adrenergic receptors, muscarinic receptors, mitogen-activated protein kinase, protein synthesis, long-term memory formation
- MeSH terms
- Adrenergic beta-Antagonists, Animals, Anisomycin, Cerebral Cortex, Conditioning, Psychological, Extinction, Psychological, Learning, Male, Memory, Protein Synthesis Inhibitors, Receptors, Adrenergic, beta, Receptors, Muscarinic, Reinforcement, Psychology, Saccharin, Taste, Protein Biosynthesis, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Lithium Chloride, Muscarinic Antagonists, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Rats
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