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Control of a Genetic Regulatory Network by a Selector Gene
Abstract
The formation of many complex structures is controlled by a special class of transcription factors encoded by selector genes. It is shown that SCALLOPED, the DNA binding component of the selector protein complex for the Drosophila wing field, binds to and directly regulates the cis-regulatory elements of many individual target genes within the genetic regulatory network controlling wing development. Furthermore, combinations of binding sites for SCALLOPED and transcriptional effectors of signaling pathways are necessary and sufficient to specify wing-specific responses to different signaling pathways. The obligate integration of selector and signaling protein inputs on cis-regulatory DNA may be a general mechanism by which selector proteins control extensive genetic regulatory networks during development.
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Cites
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Vaudin, P., Delanoue, R., Davidson, I., Silber, J., & Zider1, A. (1999) · Development · doi:10.1242/dev.126.21.4807 · Cited by 133
Cited by
Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630
New genes as drivers of phenotypic evolution
Chen, S., Krinsky, B. H., & Long, M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3521 · Cited by 428
Suboptimization of developmental enhancers
Farley, E. K., Olson, K. M., Zhang, W., Brandt, A. J., Rokhsar, D. S., & Levine, M. S. (2015) · Science · doi:10.1126/science.aac6948 · Cited by 319
Single-Cell Transcriptional Analysis of Neuronal Progenitors
Tietjen, I., Rihel, J. M., Cao, Y., Koentges, G., Zakhary, L., & Dulac, C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00229-0 · Cited by 260
Metadata
- Authors
- Guss, K. A., Nelson, C. E., Hudson, A., Kraus, M. E., & Carroll, S. B.
- Venue
- Science
- Published
- 2001-05-11
- Volume
- 292
- Issue
- 5519
- Pages
- 1164-1167
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049809163
- Cited by
- 174
- References
- 2
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guss, K. A., Nelson, C. E., Hudson, A., Kraus, M. E., & Carroll, S. B. (2001). Control of a Genetic Regulatory Network by a Selector Gene. Science. https://doi.org/10.1126/science.1058312
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
