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Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
Abstract
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.
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Cited by
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Velu, V., Titanji, K., Zhu, B., Husain, S., Pladevega, A., Lai, L., Vanderford, T. H., Chennareddi, L., Silvestri, G., Freeman, G. J., et al. (2009) · Nature · doi:10.1038/nature07662 · Cited by 771
Self-citationHeterologous prime-boost vaccination
Lu, S. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.016 · Cited by 481
Pantaleo, G., & Koup, R. A. (2004) · Nature Medicine · doi:10.1038/nm0804-806 · Cited by 444
Yang, Y., Huang, C.-T., Huang, X., & Pardoll, D. M. (2004) · Nature Immunology · doi:10.1038/ni1059 · Cited by 425
Metadata
- Authors
- Amara, R. R.
- Venue
- Science
- Published
- 2001-03-08
- Volume
- 292
- Issue
- 5514
- Pages
- 69-74
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2149791183
- Cited by
- 1,106
- References
- 0
- FWCI
- 49.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amara, R. R. (2001). Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine. Science. https://doi.org/10.1126/science.1058915
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
