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RETRACTED: Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation
Open accessAbstract
Netrins stimulate and orient axon growth through a mechanism requiring receptors of the DCC family. It has been unclear, however, whether DCC proteins are involved directly in signaling or are mere accessory proteins in a receptor complex. Further, although netrins bind cells expressing DCC, direct binding to DCC has not been demonstrated. Here we show that netrin-1 binds DCC and that the DCC cytoplasmic domain fused to a heterologous receptor ectodomain can mediate guidance through a mechanism involving derepression of cytoplasmic domain multimerization. Activation of the adenosine A2B receptor, proposed to contribute to netrin effects on axons, is not required for rat commissural axon outgrowth or Xenopus spinal axon attraction to netrin-1. Thus, DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
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Cited by
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Stein, E., & Tessier-Lavigne, M. (2001) · Science · doi:10.1126/science.1058445 · Cited by 601
Self-citationRetractedHypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote-Garcia, J. C., Unertl, K., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406
Subcellular Profiling Reveals Distinct and Developmentally Regulated Repertoire of Growth Cone mRNAs
Zivraj, K. H., Tung, Y. C. L., Piper, M., Gumy, L., Fawcett, J. W., Yeo, G. S. H., & Holt, C. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1800-10.2010 · Cited by 315
Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones
Campbell, D. S., & Holt, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00158-2 · Cited by 303
Metadata
- Authors
- Stein, E., Zou, Y., Poo, M.-M., & Tessier-Lavigne, M.
- Venue
- Science
- Published
- 2001-03-09
- Volume
- 291
- Issue
- 5510
- Pages
- 1976-1982
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2126076154
- Cited by
- 242
- References
- 0
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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- Stein, E., Zou, Y., Poo, M.-M., & Tessier-Lavigne, M. (2001). RETRACTED: Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation. Science. https://doi.org/10.1126/science.1059391
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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