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Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response
Abstract
The COP9 signalosome is an evolutionary conserved multiprotein complex of unknown function that acts as a negative regulator of photomorphogenic seedling development in Arabidopsis . Here, we show that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCF TIR1 . Furthermore, we found that the COP9 signalosome and SCF TIR1 interacted in vivo and that the COP9 signalosome was required for efficient degradation of PSIAA6, a candidate substrate of SCF TIR1 . Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase–mediated responses.
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Citations
Cited by
Auxin: Regulation, Action, and Interaction
WOODWARD, A. W. (2005) · Annals of Botany · doi:10.1093/aob/mci083 · Cited by 2,340
Function and regulation of cullin–RING ubiquitin ligases
Petroski, M. D., & Deshaies, R. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1547 · Cited by 2,148
Self-citationPromotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
Lyapina, S., Cope, G., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D. A., Wei, N., Shevchenko, A., & Deshaies, R. J. (2001) · Science · doi:10.1126/science.1059780 · Cited by 698
Self-citationAuxin Receptors and Plant Development: A New Signaling Paradigm
Mockaitis, K., & Estelle, M. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123214 · Cited by 651
Self-citationThe Ubiquitin-Proteasome Pathway and Plant Development
Moon, J., Parry, G., & Estelle, M. (2004) · The Plant Cell · doi:10.1105/tpc.104.161220 · Cited by 586
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Metadata
- Authors
- Schwechheimer, C., Serino, G., Callis, J., Crosby, W. L., Lyapina, S., Deshaies, R. J., Gray, W. M., Estelle, M., & Deng, X.-W.
- Venue
- Science
- Published
- 2001-05-18
- Volume
- 292
- Issue
- 5520
- Pages
- 1379-1382
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053763318
- Cited by
- 474
- References
- 0
- FWCI
- 72.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwechheimer, C., Serino, G., Callis, J., Crosby, W. L., Lyapina, S., Deshaies, R. J., Gray, W. M., Estelle, M., & Deng, X.-W. (2001). Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response. Science. https://doi.org/10.1126/science.1059776
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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