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Hemichannel-Mediated Inhibition in the Outer Retina
Abstract
An essential feature of the first synapse in the retina is a negative feedback pathway from horizontal cells to cones. Here we show that at this synapse, connexin26 forms hemichannels on horizontal cell dendrites near the glutamate release site of the cones. Blocking these hemichannels hyperpolarizes horizontal cells, modulates the Ca 2+ channels of the cones, and abolishes all feedback-mediated responses. We propose a feedback mechanism in which the activity of the Ca 2+ channels and the subsequent glutamate release of the cones are modulated by a current through these hemichannels. Because the current through the hemichannels depends on the polarization of the horizontal cells, their activity modulates the output of the cones.
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Cited by
ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
Connors, B. W., & Long, M. A. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131128 · Cited by 784
Contreras, J. E., Sánchez, H. A., Véliz, L. P., Bukauskas, F. F., Bennett, M. V. L., & Sáez, J. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.002 · Cited by 244
Carbenoxolone Inhibition of Voltage-Gated Ca Channels and Synaptic Transmission in the Retina
Vessey, J. P., Lalonde, M. R., Mizan, H. A., Welch, N. C., Kelly, M. E. M., & Barnes, S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00148.2004 · Cited by 178
Ephaptic coupling to endogenous electric field activity: Why bother?
Anastassiou, C. A., & Koch, C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.002 · Cited by 171
Metadata
- Authors
- Kamermans, M., Fahrenfort, I., Schultz, K., Janssen-Bienhold, U., Sjoerdsma, T., & Weiler, R.
- Venue
- Science
- Published
- 2001-05-11
- Volume
- 292
- Issue
- 5519
- Pages
- 1178-1180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067143949
- Cited by
- 359
- References
- 0
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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