The DOI matches its Crossref record.
Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters
Abstract
Zebrafish are a valuable model for mammalian lipid metabolism; larvae process lipids similarly through the intestine and hepatobiliary system and respond to drugs that block cholesterol synthesis in humans. After ingestion of fluorescently quenched phospholipids, endogenous lipase activity and rapid transport of cleavage products results in intense gall bladder fluorescence. Genetic screening identifies zebrafish mutants, such as fat free , that show normal digestive organ morphology but severely reduced phospholipid and cholesterol processing. Thus, fluorescent lipids provide a sensitive readout of lipid metabolism and are a powerful tool for identifying genes that mediate vertebrate digestive physiology.
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Citations
Cited by
Zebrafish: A new model on the pharmaceutical catwalk
Langheinrich, U. (2003) · BioEssays · doi:10.1002/bies.10326 · Cited by 332
The Zebrafish as a Model Organism to Study Development of the Immune System
TRAVER, D., HERBOMEL, P., PATTON, E. E., MURPHEY, R. D., YODER, J. A., LITMAN, G. W., CATIC, A., AMEMIYA, C. T., ZON, L. I., & TREDE, N. S. (2003) · Advances in Immunology · doi:10.1016/s0065-2776(03)81007-6 · Cited by 276
Ghaffari, K., Pierce, L. X., Roufaeil, M., Gibson, I., Tae, K., Sahoo, S., Cantrell, J. R., Andersson, O., Lau, J., & Sakaguchi, T. F. (2021) · PLOS Genetics · doi:10.1371/journal.pgen.1009402 · Cited by 5
Metadata
- Authors
- Farber, S. A., Pack, M., Ho, S.-Y., Johnson, I. D., Wagner, D. S., Dosch, R., Mullins, M. C., Hendrickson, H. S., Hendrickson, E. K., & Halpern, M. E.
- Venue
- Science
- Published
- 2001-05-18
- Volume
- 292
- Issue
- 5520
- Pages
- 1385-1388
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979771830
- Cited by
- 309
- References
- 0
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Farber, S. A., Pack, M., Ho, S.-Y., Johnson, I. D., Wagner, D. S., Dosch, R., Mullins, M. C., Hendrickson, H. S., Hendrickson, E. K., & Halpern, M. E. (2001). Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters. Science. https://doi.org/10.1126/science.1060418
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
