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Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein
Abstract
Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought to be the basis of cochlear amplification, is mediated by a voltage-sensitive motor molecule recently identified as the membrane protein prestin. Here, we show that voltage sensitivity is conferred to prestin by the intracellular anions chloride and bicarbonate. Removal of these anions abolished fast voltage-dependent motility, as well as the characteristic nonlinear charge movement (“gating currents”) driving the underlying structural rearrangements of the protein. The results support a model in which anions act as extrinsic voltage sensors, which bind to the prestin molecule and thus trigger the conformational changes required for motility of OHCs.
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Citations
Cited by
Cochlear Outer Hair Cell Motility
Ashmore, J. (2008) · Physiological Reviews · doi:10.1152/physrev.00044.2006 · Cited by 503
Central gain control in tinnitus and hyperacusis
Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00206 · Cited by 439
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
Boettger, T., Hübner, C. A., Maier, H., Rust, M. B., Beck, F. X., & Jentsch, T. J. (2002) · Nature · doi:10.1038/416874a · Cited by 414
Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification
Dallos, P., Wu, X., Cheatham, M. A., Gao, J., Zheng, J., Anderson, C. T., Jia, S., Wang, X., Cheng, W. H. Y., Sengupta, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.028 · Cited by 414
Self-citationFunctional Characterization of Pendrin in a Polarized Cell System
Gillam, M. P., Sidhaye, A. R., Lee, E. J., Rutishauser, J., Stephan, C. W., & Kopp, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313648200 · Cited by 149
Metadata
- Authors
- Oliver, D., He, D. Z. Z., Klöcker, N., Ludwig, J., Schulte, U., Waldegger, S., Ruppersberg, J. P., Dallos, P., & Fakler, B.
- Venue
- Science
- Published
- 2001-06-22
- Volume
- 292
- Issue
- 5525
- Pages
- 2340-2343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981531296
- Cited by
- 473
- References
- 0
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oliver, D., He, D. Z. Z., Klöcker, N., Ludwig, J., Schulte, U., Waldegger, S., Ruppersberg, J. P., Dallos, P., & Fakler, B. (2001). Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein. Science. https://doi.org/10.1126/science.1060939
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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