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Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells
Abstract
Cell division depends on the separation of sister chromatids in anaphase. In yeast, sister separation is initiated by cleavage of cohesin by the protease separase. In vertebrates, most cohesin is removed from chromosome arms by a cleavage-independent mechanism. Only residual amounts of cohesin are cleaved at the onset of anaphase, coinciding with its disappearance from centromeres. We have identified two separase cleavage sites in the human cohesin subunit SCC1 and have conditionally expressed noncleavable SCC1 mutants in human cells. Our results indicate that cohesin cleavage by separase is essential for sister chromatid separation and for the completion of cytokinesis.
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Cited by
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
Telomeres in cancer: tumour suppression and genome instability
Maciejowski, J., & de Lange, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.171 · Cited by 745
Kao, J., Salari, K., Bocanegra, M., Choi, Y.-L., Girard, L., Gandhi, J., Kwei, K. A., Hernandez-Boussard, T., Wang, P., Gazdar, A. F., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006146 · Cited by 788
Tanaka, T. U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M. J. R., & Nasmyth, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00633-5 · Cited by 722
Wapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
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Metadata
- Authors
- Hauf, S., Waizenegger, I. C., & Peters, J.-M.
- Venue
- Science
- Published
- 2001-08-17
- Volume
- 293
- Issue
- 5533
- Pages
- 1320-1323
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014089858
- Cited by
- 499
- References
- 0
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hauf, S., Waizenegger, I. C., & Peters, J.-M. (2001). Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells. Science. https://doi.org/10.1126/science.1061376
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
