The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
Abstract
Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“At least in some settings, detachment from the extracellular matrix triggers MOMP upon activation of the BH3-only proteins BIM and BMF [137, 235].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [137]
Citations
Cites
Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112
Hidden Markov Models in Computational Biology
Krogh, A., Brown, M., Mian, S. I., Sjölander, K. V., & Haussler, D. H. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1104 · Cited by 1,948
Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M., & Strasser, A. (1999) · Science · doi:10.1126/science.286.5445.1735 · Cited by 1,504
Self-citationYin, X.-M., Oltvai, Z., & Korsmeyer, S. (1994) · Nature · doi:10.1038/369321a0 · Cited by 1,383
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., & Vogelstein, B. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00213-1 · Cited by 1,289
Bim: a novel member of the Bcl‐2 family that promotes apoptosis
O’Connor, L., Strasser, A., O’Reilly, L. A., Hausmann, G., Adams, J. M., Cory, S., & Huang, D. C. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.384 · Cited by 1,163
Self-citationFrisch, S. M., & Ruoslahti, E. I. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80124-x · Cited by 1,159
Puthalakath, H., Huang, D. C. S., O'REILLY, L. A., King, S. M., & Strasser, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80456-6 · Cited by 1,053
Self-citation
Research works printed but not linked: 4
- H. Puthalakath D. C. S. Huang L. A. O'Reilly
- Supplementary material is available on Science Online at www.sciencemag.org/cgi/content/full/293/5536/1829/DC1
- Wick W., et al., Oncogene 12, 973 (1996).
- We thank L. O'Connor and K. Newton for help with experiments and sequence analysis L. Cullen and S. Novakovic for expert technical assistance J. Visvader and W. Alexander for reagents and G. Filby for editorial assistance. We are grateful to J. Adams P. Bouillet A. Harris and S. Cory for critical review of the manuscript. This work was supported by fellowships and grants from the National Health and Medical Research Council (Canberra; Reg. Key 973002) the U.S. National Cancer Institute (CA 80188) the Dr Josef Steiner Cancer Research Foundation the Leukemia and Lymphoma Society of America the Human Frontiers Science Program and the Sylvia and Charles Viertel Charitable Foundation. The sequences for mouse bmf human bmf and mouse dlc 2 have been deposited with GenBank (accession numbers: and respectively).
Cited by
Sorted by citations
Items 201–300 of 658
The control of apoptosis in lymphocyte selection
Strasser, A., & Bouillet, P. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00036.x · Cited by 83
Self-citationWong, H. K., Fricker, M., Wyttenbach, A., Villunger, A., Michalak, E. M., Strasser, A., & Tolkovsky, A. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.19.8732-8747.2005 · Cited by 81
Self-citationBcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma
Niizuma, H., Nakamura, Y., Ozaki, T., Nakanishi, H., Ohira, M., Isogai, E., Kageyama, H., Imaizumi, M., & Nakagawara, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209515 · Cited by 79
Wu, H., Medeiros, L. J., & Young, K. H. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.08.004 · Cited by 80
Moon, E., & Lerner, A. (2003) · Blood · doi:10.1182/blood-2002-10-3208 · Cited by 79
Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice
Roset, R. (2007) · Frontiers in bioscience · doi:10.2741/2421 · Cited by 80
Apoptosis commitment – translating survival signals into decisions on mitochondria
Keeble, J. A., & Gilmore, A. P. (2007) · Cell Research · doi:10.1038/cr.2007.101 · Cited by 80
Hur, J., Chesnes, J., Coser, K. R., Lee, R. S., Geck, P., Isselbacher, K. J., & Shioda, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307337101 · Cited by 81
Spike, a novel BH3‐only protein, regulates apoptosis at the endoplasmic reticulum
Mund, T., Gewies, A., Schoenfeld, N., Bauer, M. K. A., & Grimm, S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0657fje · Cited by 78
The third model of Bax/Bak activation: a Bcl-2 family feud finally resolved?
Luo, X., O’Neill, K. L., & Huang, K. (2020) · F1000Research · doi:10.12688/f1000research.25607.1 · Cited by 77
VanBrocklin, M. W., Verhaegen, M. E., Soengas, M. S., & Holmen, S. L. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3934 · Cited by 77
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
Day, C. L., Puthalakath, H., Gretchen, S. K. E. A., Strasser, A., Barsukov, I., Lian, L., Huang, D. C. S., & Hinds, M. G. (2004) · Biochemical Journal · doi:10.1042/bj20031251 · Cited by 80
Self-citationIdentification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model
岩崎, 正., Kuwata, T., Yamazaki, Y., Jenkins, N. A., Copeland, N. G., Osato, M., Ito, Y., KROON, E. J., Sauvageau, G., & Nakamura, T. (2004) · Blood · doi:10.1182/blood-2004-04-1508 · Cited by 77
Sionov, R. V., Spokoini, R., Kfir‐Erenfeld, S., Cohen, O., & Yefenof, E. (2008) · Advances in cancer research · doi:10.1016/s0065-230x(08)00406-5 · Cited by 77
Tankyrase 1 Interacts with Mcl-1 Proteins and Inhibits Their Regulation of Apoptosis
Bae, J., Donigian, J. R., & Hsueh, A. J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m201988200 · Cited by 77
Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo
Hübner, A., Cavanagh, J., Rincón, M., Flavell, R. A., & Davis, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01155-09 · Cited by 74
Divergence from a Dedicated Cellular Suicide Mechanism: Exploring the Evolution of Cell Death
Yuan, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.008 · Cited by 73
Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin
Sanchez‐Ruderisch, H., Detjen, K. M., Welzel, M., André, S., Fischer, C., Gabius, H., & Rosewicz, S. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.148 · Cited by 72
Strasser, A., Puthalakath, H., O’Reilly, L. A., & Bouillet, P. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100141 · Cited by 72
Self-citationMitotic catastrophe and apoptosis induced by docetaxel in hormone‐refractory prostate cancer cells
Fabbri, F., Amadori, D., Carloni, S., Brigliadori, G., Tesei, A., Ulivi, P., Rosetti, M., Vannini, I., Arienti, C., Zoli, W., et al. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21522 · Cited by 69
Rapali, P., Radnai, L., Süveges, D., Harmat, V., Tölgyesi, F., Wahlgren, W. Y., Katona, G., Nyitray, L., & Pál, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018818 · Cited by 75
The role of BH3-only proteins in apoptosis within the ovary
Hutt, K. J. (2014) · Reproduction · doi:10.1530/rep-14-0422 · Cited by 73
DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis.
Shao, L., Goronzy, J. J., & Weyand, C. M. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000096 · Cited by 69
BCL2 Family, Mitochondrial Apoptosis, and Beyond
Dai, H., Meng, W., & Kaufmann, S. H. (2016) · Cancer translational medicine · doi:10.4103/2395-3977.177558 · Cited by 72
Role of Bcl-2 family members in immunity and disease
Droin, N. M., & Green, D. R. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.10.011 · Cited by 74
Shortt, J., Martin, B. P., Newbold, A., Hannan, K. M., Devlin, J. R., Baker, A. J., Ralli, R., Cullinane, C. M., Schmitt, C. A., Reimann, M., et al. (2013) · Blood · doi:10.1182/blood-2012-08-446096 · Cited by 69
Qu, J., Qiu, B., Zhang, Y., Hu, Y., Wang, Z., Guan, Z., Qin, Y., Sui, T., Wu, F., Li, B., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01666-3 · Cited by 69
Alfredsson, J., Puthalakath, H., Martin, H. M., Strasser, A., & Nilsson, G. P. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401537 · Cited by 67
Self-citationBcl-2 family-regulated apoptosis in health and disease
Kluck, R. M. (2010) · Cell Health and Cytoskeleton · doi:10.2147/chc.s6228 · Cited by 72
Bcl‐2‐related protein family gene expression during oligodendroglial differentiation
Itoh, T., Itoh, A., & Pleasure, D. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01795.x · Cited by 68
The increase in mitochondrial association with actin precedes Bax translocation in apoptosis
Tang, H. L., Le, A.-H., & Lung, H. L. (2006) · Biochemical Journal · doi:10.1042/bj20060241 · Cited by 67
Makani, S. S., Gollapudi, S., Yel, L., Chiplunkar, S., & Gupta, S. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363854 · Cited by 67
Dimitriadis, F., Tsiampali, C., Chaliasos, N., Tsounapi, P., Takenaka, A., & Sofikitis, N. (2015) · HORMONES · doi:10.14310/horm.2002.1633 · Cited by 66
Saber, A., Alipour, B., Faghfoori, Z., & Khosroushahi, A. Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.05.007 · Cited by 67
Involvement of the Actin Machinery in Programmed Cell Death
Ren, W., Zhao, W., Cao, L., & Huang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634849 · Cited by 67
Kandaswamy, R., Sava, G. P., Speedy, H. E., Beà, S., Martín-Subero, J. I., Studd, J. B., Migliorini, G., Law, P., Puente, X. S., Martin‐García, D., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.053 · Cited by 64
CD154 induces a switch in pro‐survival Bcl‐2 family members in chronic lymphocytic leukaemia
Willimott, S., Baou, M., Naresh, K. N., & Wagner, S. D. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06717.x · Cited by 63
BH3‐only proteins: The death‐puppeteer's wires
Ghiotto, F., Fais, F., & Bruno, S. (2009) · Cytometry Part A · doi:10.1002/cyto.a.20819 · Cited by 65
Integrin-Mediated Adhesion: Tipping the Balance between Chemosensitivity and Chemoresistance
Zutter, M. M. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74039-3_6 · Cited by 63
The association of viral proteins with host cell dynein components during virus infection
Merino, J., García‐Mayoral, M. F., & Rodríguez‐Crespo, I. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08252.x · Cited by 62
Adachi, M., & Imai, K. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401097 · Cited by 62
Engel, T., Plesnila, N., Prehn, J. H. M., & Henshall, D. C. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.26 · Cited by 64
There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum
Annis, M. G., Yethon, J. A., Leber, B. F., & Andrews, D. W. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.07.001 · Cited by 62
Types of Cell Death from a Molecular Perspective
Hajibabaie, F., Abedpoor, N., & Mohamadynejad, P. (2023) · Biology · doi:10.3390/biology12111426 · Cited by 69
Anti-cancer drug discovery and development
Liu, Q., & Wang, H. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.21554 · Cited by 63
Regulation of anoikis by Cdc42 and Rac1
Cheng, T., Symons, M. H., & Jou, T. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.002 · Cited by 60
Sofikitis, N., Pappas, E., Kawatani, A., Baltogiannis, D., Loutradis, D., Kanakas, N., Giannakis, D., Dimitriadis, F., Τσουκανέλης, Κ., Georgiou, I. A., et al. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi007 · Cited by 61
Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members
Tischner, D., Manzl, C., Soratroi, C., Villunger, A., & Krumschnabel, G. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0756-8 · Cited by 59
Self-citationHayakawa, K., Formica, A. M., Brill‐Dashoff, J., Shinton, S. A., Ichikawa, D., Zhou, Y., Morse, H. C., & Hardy, R. R. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160712 · Cited by 60
Hódi, Z., Németh, A. L., Radnai, L., Hetényi, C., Schlett, K., Bodor, A., Perczel, A., & Nyitray, L. (2006) · Biochemistry · doi:10.1021/bi060991e · Cited by 59
Loro, L. L., Vintermyr, O., & Johannessen, A. C. (2003) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2003.00052.x · Cited by 59
Hornsveld, M., Tenhagen, M., van de Ven, R. A., de Vries-Smits, A. M. M., van Triest, M. H., van Amersfoort, M., Kloet, D. E. A., Dansen, T. B., Burgering, B. M. T., & Derksen, P. W. B. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.33 · Cited by 60
Delbridge, A. R. D., Kueh, A. J., Ke, F., Zamudio, N., El-Saafin, F., Jansz, N., Wang, G., Iminitoff, M., Beck, T. J., Haupt, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.048 · Cited by 65
Self-citationPetry, I. B., Fieber, E., Schmidt, M., Gehrmann, M. C., Gebhard, S., Hermes, M., Schormann, W., Selinski, S., Freis, E., Schwender, H. R., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1617 · Cited by 59
Cell Death Signaling and Anticancer Therapy
Galluzzi, L., Vitale, I., Vacchelli, E., & Kroemer, G. (2011) · Frontiers in Oncology · doi:10.3389/fonc.2011.00005 · Cited by 61
Mebratu, Y. A., Dickey, B. F., Evans, C., & Tesfaigzi, Y. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801186 · Cited by 61
Roles of Mir-200 Family Members in Lung Cancer: More Than Tumor Suppressors
Liu, C., Hu, W., Li, L.-L., Wang, Y., Zhou, Q. Y., Zhang, F., Songyang, Y., Zhu, W., Sun, C., & Li, D. (2018) · Future Oncology · doi:10.2217/fon-2018-0155 · Cited by 59
The Bcl-2 protein family and its role in the development of neoplastic disease
Heiser, D., Labi, V., Erlacher, M., & Villunger, A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.011 · Cited by 59
Self-citationGoldsmith, K. C., Lestini, B. J., Gross, M., Ip, L. R. H., Bhumbla, A., Zhang, X., Zhao, H., Liu, X., & Hogarty, M. D. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.171 · Cited by 57
Othman, N., & Nagoor, N. H. (2014) · BioMed Research International · doi:10.1155/2014/318030 · Cited by 57
Beswick, R. W., Ambrose, H. E., & Wagner, S. D. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.08.009 · Cited by 57
Liu, J.-W., Chandra, D., Tang, S.-H., Chopra, D. P., & Tang, D. G. (2002) · PubMed · Cited by 56
Programmed cell death in the skin
Costanzo, A., Fausti, F., Spallone, G., Moretti, F., Narcisi, A., & Botti, E. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150050ac · Cited by 55
Widau, R. C., Jin, Y., Dixon, S. A. H., Wadzinski, B. E., & Gallagher, P. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085076 · Cited by 55
Wiegmans, A. P., Alsop, A. E., Bots, M. L., Cluse, L. A., Williams, S. P., Banks, K.-M., Ralli, R., Scott, C. L., Frenzel, A., Villunger, A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3289 · Cited by 53
Self-citationDetachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells
Liu, Z., Li, H., Wu, X., Yoo, B. H., Yan, S. R., Stadnyk, A. W., Sasazuki, T., Shirasawa, S., LaCasse, E. C., Korneluk, R. G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209753 · Cited by 54
ras Oncogene Triggers Up-regulation of cIAP2 and XIAP in Intestinal Epithelial Cells
Liu, Z., Li, H., Derouet, M. F., Filmus, J., LaCasse, E. C., Korneluk, R. G., Kerbel, R. S., & Rosen, K. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503724200 · Cited by 54
Mechanical Regulation of Apoptosis in the Cardiovascular System
Goldblatt, Z. E., Cirka, H. A., & Billiar, K. L. (2020) · Annals of Biomedical Engineering · doi:10.1007/s10439-020-02659-x · Cited by 53
BCL-2 Modifying Factor (BMF) Is a Central Regulator of Anoikis in Human Intestinal Epithelial Cells
Hausmann, M., Leucht, K., Ploner, C., Kießling, S., Villunger, A., Becker, H. M., Hofmann, C., Falk, W., Krebs, M., Kellermeier, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.265322 · Cited by 53
Self-citationThe Structural Biology of BH3-Only Proteins
Kvansakul, M., & Hinds, M. G. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-417158-9.00003-0 · Cited by 55
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
Grespi, F., Soratroi, C., Krumschnabel, G., Sohm, B., Ploner, C., Geley, S., Hengst, L., Häcker, G. A., & Villunger, A. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.97 · Cited by 53
Self-citationDeath by Committee: Organellar Trafficking and Communication in Apoptosis
Aslan, J. E., & Thomas, G. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00951.x · Cited by 51
BH3-Only Proteins and Their Effects on Cancer
Vo, T.-T. T., & Letai, A. G. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6706-0_3 · Cited by 54
Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the Gut
Liebing, E., Krug, S. M., Neurath, M. F., Siegmund, B., & Becker, C. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101423 · Cited by 52
BH3‐only proteins: Integrated control point of apoptosis
Shibue, T., & Taniguchi, T. (2006) · International Journal of Cancer · doi:10.1002/ijc.21751 · Cited by 54
Bhuiyan, M. S., & Fukunaga, K. (2008) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2008.00052.x · Cited by 50
Ghosh‐Roy, A., Desai, B. S., & Ray, K. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0103 · Cited by 50
Cottet, S., Michaut, L., Boisset, G., Schlecht, U., Gehring, W., & Schorderet, D. F. (2006) · The FASEB Journal · doi:10.1096/fj.06-6211com · Cited by 50
Fukazawa, H., Noguchi, K., Masumi, A., Murakami, Y., & Uehara, Y. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1281.3.10 · Cited by 50
Deacetylation of p53 induces autophagy by suppressing Bmf expression
Contreras, A. U., Mebratu, Y., Delgado, M., Montano, G., Hu, C.-A. A., Ryter, S. W., Choi, A. M. K., Lin, Y., Xiang, J., Chand, H., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201205064 · Cited by 48
Apoptotic Cell Death and Function of Cryopreserved Porcine Hepatocytes in a Bioartificial Liver
Matsushita, T., Yagi, T., Hardin, J. A., Cragun, J. D., Crow, F. W., Bergen, H. R., Gores, G. J., & Nyberg, S. L. (2003) · Cell Transplantation · doi:10.3727/000000003108746696 · Cited by 48
Müller, A., Zang, C., Chumduri, C., Dörken, B., Daniel, P. T., & Scholz, C. W. (2013) · International Journal of Cancer · doi:10.1002/ijc.28206 · Cited by 51
O’Reilly, L. A., Divisekera, U., Newton, K., Scalzo‐Inguanti, K., Kataoka, T., Puthalakath, H., Ito, M., Huang, D. C. S., & Strasser, A. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401408 · Cited by 47
Self-citationKilbride, S. M., Farrelly, A. M., Bonner, C., Ward, M. W., Nyhan, K. C., Concannon, C. G., Wollheim, C. B., Byrne, M. M., & Prehn, J. H. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138107 · Cited by 46
Current Strategies in Overcoming Resistance of Cancer Cells to Apoptosis Melanoma as a Model
Hersey, P., Zhuang, L., & Zhang, X. D. (2006) · International review of cytology · doi:10.1016/s0074-7696(06)51004-6 · Cited by 49
Bose, S., & Kim, H. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/363076 · Cited by 46
Direct addition of BimL to mitochondria does not lead to cytochrome c release
Terradillos, O., Montessuit, S., Huang, D. C. S., & Martinou, J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02871-5 · Cited by 46
Self-citationLiu, Z., Li, H., Derouet, M. F., Berezkin, A., Sasazuki, T., Shirasawa, S., & Rosen, K. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508664200 · Cited by 45
Proactive and reactive roles of TGF-β in cancer
Kuburich, N. A., Sabapathy, T., Demestichas, B. R., Maddela, J. J., den Hollander, P., & Mani, S. A. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.08.002 · Cited by 43
Long-living Ames dwarf mouse hepatocytes readily undergo apoptosis
Kennedy, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00164-5 · Cited by 44
Pandey, M., Gowda, K., Doi, K., Sharma, A. K., Wang, H.-G., & Amin, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078570 · Cited by 43
Ma, Z., Yang, Y., Zou, L., & Luo, K. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-61 · Cited by 43
Davies, M. R., Ribeiro, L. R., Downey-Jones, M. D., Needham, M., Oakley, C., & Wardale, J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24550 · Cited by 42
Host-Cell Survival and Death During Chlamydia Infection
Ying, S., Pettengill, M. A., Ojcius, D. M., & Häcker, G. A. (2007) · Current Immunology Reviews · doi:10.2174/157339507779802179 · Cited by 42
Characterization of an alternative BAK-binding site for BH3 peptides
Ye, K., Meng, W. X., Sun, H., Wu, B., Chen, M., Pang, Y., Gao, J., Wang, H., Wang, J., Kaufmann, S. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17074-y · Cited by 40
Wang, W., Lo, K. W. ‐., Kan, H.-M., Fan, J., & Zhang, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307118200 · Cited by 42
Liew, S. H., Nguyen, Q., Strasser, A., Findlay, J. K., & Hutt, K. J. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.361 · Cited by 41
Self-citationIn Situ Single‐Cell Western Blot on Adherent Cell Culture
Zhang, Y., Naguro, I., & Herr, A. E. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906920 · Cited by 41
Morales, A. A., Olsson, A., Celsing, F., Österborg, A., Jondal, M., & Osorio, L. M. (2003) · Leukemia · doi:10.1038/sj.leu.2403183 · Cited by 42
FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms
Czymai, T., Viemann, D., Sticht, C., Molema, G., Goebeler, M., & Schmidt, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.056663 · Cited by 41
Metadata
- Authors
- Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A.
- Affiliations
- The Royal Melbourne Hospital (AU)
- The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. Royal Melbourne Hospital, 3050 VIC, Australia.
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Strasser, Andreas
- ORCID
- Venue
- Science
- Published
- 2001-09-07
- Volume
- 293
- Issue
- 5536
- Pages
- 1829-1832
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993059855
- Cited by
- 656
- References
- 24
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 13 · 2023: 16 · 2022: 12 · 2021: 41 · 2020: 10 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 23 · 2014: 14 · 2013: 25 · 2012: 27
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (#CA 80188, R01CA080188)
- National Institute on Deafness and Other Communication Disorders (R29DC003299)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- BMF, BH3-only proteins, apoptosis, myosin V, anoikis, Bcl-2 family proteins, cytoskeleton, building information modeling, protein translocation
- MeSH terms
- Bcl-2-Like Protein 11, Amino Acid Sequence, Animals, Calmodulin-Binding Proteins, Carrier Proteins, Cell Line, Cytoskeleton, Dyneins, Humans, Membrane Proteins, Molecular Sequence Data, Mutation, Neoplasm Proteins, Nerve Tissue Proteins, Protein Binding, Proto-Oncogene Proteins, RNA, Messenger, Transfection, Protein Structure, Tertiary, Proto-Oncogene Proteins c-bcl-2, Molecular Motor Proteins, Two-Hybrid System Techniques, Gene Expression Profiling, Protein Transport, Anoikis, Myosin Type V, Drosophila Proteins, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Mice, Myeloid Cell Leukemia Sequence 1 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review