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Bt Toxin Resistance from Loss of a Putative Carbohydrate-Modifying Enzyme
Abstract
The development of resistance is the main threat to the long-term use of toxins from Bacillus thuringiensis (Bt) in transgenic plants. Here we report the cloning of a Bt toxin resistance gene, Caenorhabditis elegans bre-5 , which encodes a putative β-1,3-galactosyltransferase. Lack of bre-5 in the intestine led to resistance to the Bt toxin Cry5B. Wild-type but not bre-5 mutant animals were found to uptake toxin into their gut cells, consistent with bre-5 mutants lacking toxin-binding sites on their apical gut. bre-5 mutants displayed resistance to Cry14A, a Bt toxin lethal to both nematodes and insects; this indicates that resistance by loss of carbohydrate modification is relevant to multiple Bt toxins.
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Citations
Cites
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Gould, F. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.701 · Cited by 1,392
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Humans as the World's Greatest Evolutionary Force
Palumbi, S. R. (2001) · Science · doi:10.1126/science.293.5536.1786 · Cited by 1,290
Role of Glycosylation in Development
Haltiwanger, R. S., & Lowe, J. B. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074043 · Cited by 757
Role of Receptors in Bacillus thuringiensis Crystal Toxin Activity
Pigott, C. R., & Ellar, D. J. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-06 · Cited by 688
Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids
Zhang, J., Khan, S. A., Hasse, C., Ruf, S., Heckel, D. G., & Bock, R. (2015) · Science · doi:10.1126/science.1261680 · Cited by 471
McGhee, J. (2007) · WormBook · doi:10.1895/wormbook.1.133.1 · Cited by 324
Metadata
- Authors
- Griffitts, J. S., Whitacre, J. L., Stevens, D. E., & Aroian, R. V.
- Venue
- Science
- Published
- 2001-08-03
- Volume
- 293
- Issue
- 5531
- Pages
- 860-864
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074565292
- Cited by
- 240
- References
- 1
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
