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Cited by 405

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Imprinting and the Epigenetic Asymmetry Between Parental Genomes

Ferguson-Smith, Anne C., Surani, M. Azim·2001·Science

Abstract

Genomic imprinting confers a developmental asymmetry on the parental genomes, through epigenetic modifications in the germ line and embryo. These heritable modifications regulate the monoallelic activity of parental alleles resulting in their functional differences during development. Specific cis -acting regulatory elements associated with imprinted genes carry modifications involving chromatin structural changes and DNA methylation. Some of these modifications are initiated in the germ line. Comparative genomic analysis at imprinted domains is emerging as a powerful tool for the identification of conserved elements amenable to more detailed functional analysis, and for providing insight into the emergence of imprinting during the evolution of mammalian species. Genomic imprinting therefore provides a model system for the analysis of the epigenetic control of genome function.

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Metadata

Authors
Ferguson-Smith, A. C., & Surani, M. A.
Venue
Science
Published
2001-08-10
Volume
293
Issue
5532
Pages
1086-1089
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2056069396
Cited by
405
References
55
FWCI
19.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Imprinting and the Epigenetic Asymmetry Between Parental Genomes. https://app.cochat.ai/papers/10.1126/science.1064020
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Ferguson-Smith, A. C., & Surani, M. A. (2001). Imprinting and the Epigenetic Asymmetry Between Parental Genomes. Science. https://doi.org/10.1126/science.1064020

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.