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Role of Erv29p in Collecting Soluble Secretory Proteins into ER-Derived Transport Vesicles
Abstract
Proteins are transported from the endoplasmic reticulum (ER) in vesicles formed by coat protein complex II (COPII). Soluble secretory proteins are thought to leave the ER in these vesicles by “bulk flow” or through recognition by hypothetical shuttling receptors. We found that Erv29p, a conserved transmembrane protein, was directly required for packaging glycosylated pro-α-factor (gpαf) into COPII vesicles in Saccharomyces cerevisiae . Further, an Erv29p-gpαf complex was isolated from ER-derived transport vesicles. In vivo, export of gpαf from the ER was saturable and depended on the expression level of Erv29p. These results indicate that membrane receptors can link soluble cargo proteins to the COPII coat.
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Citations
Cited by
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
Lee, M. C. S., Miller, E. A., Goldberg, J., Orci, L., & Schekman, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.105307 · Cited by 813
Mayor, S., & Riezman, H. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1309 · Cited by 428
A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation
Denic, V., Quan, E. M., & Weissman, J. S. (2006) · Cell · doi:10.1016/j.cell.2006.05.045 · Cited by 422
Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway
Barlowe, C. K., & Miller, E. A. (2013) · Genetics · doi:10.1534/genetics.112.142810 · Cited by 330
Self-citationBleeding due to disruption of a cargo-specific ER-to-Golgi transport complex
Zhang, B., Cunningham, M. A., Nichols, W. C., Bernat, J. A., Seligsohn, U., Pipe, S. W., McVey, J. H., Schulte-Overberg, U., de Bosch, N. B., Ruiz-Saez, A., et al. (2003) · Nature Genetics · doi:10.1038/ng1153 · Cited by 309
Metadata
- Authors
- Belden, W. J., & Barlowe, C.
- Venue
- Science
- Published
- 2001-11-16
- Volume
- 294
- Issue
- 5546
- Pages
- 1528-1531
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041674095
- Cited by
- 214
- References
- 0
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
