The DOI matches its Crossref record.
Activation of Orphan Receptors by the Hormone Relaxin
Abstract
Relaxin is a hormone important for the growth and remodeling of reproductive and other tissues during pregnancy. Although binding sites for relaxin are widely distributed, the nature of its receptor has been elusive. Here, we demonstrate that two orphan heterotrimeric guanine nucleotide binding protein (G protein)–coupled receptors, LGR7 and LGR8, are capable of mediating the action of relaxin through an adenosine 3′,5′-monophosphate (cAMP)–dependent pathway distinct from that of the structurally related insulin and insulin-like growth factor family ligand. Treatment of antepartum mice with the soluble ligand-binding region of LGR7 caused parturition delay. The wide and divergent distribution of the two relaxin receptors implicates their roles in reproductive, brain, renal, cardiovascular, and other functions.
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Cited by
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Relaxin family peptides and their receptors
Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534
Roh, J., Chang, C. L., Bhalla, A., Klein, C., & Hsu, S. Y. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305332200 · Cited by 443
Self-citationSamuel, C. S., Unemori, E. N., Mookerjee, I., Bathgate, R. A. D., Layfield, S. L., Mak, J., Tregear, G. W., & Du, X.-J. (2004) · Endocrinology · doi:10.1210/en.2004-0209 · Cited by 288
Cardiovascular effects of relaxin: from basic science to clinical therapy
Du, X.-J., Bathgate, R. A. D., Samuel, C. S., Dart, A. M., & Summers, R. J. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.198 · Cited by 188
Metadata
- Authors
- Hsu, S. Y., Nakabayashi, K., Nishi, S., Kumagai, J., Kudo, M., Sherwood, O. D., & Hsueh, A. J. W.
- Venue
- Science
- Published
- 2002-01-25
- Volume
- 295
- Issue
- 5555
- Pages
- 671-674
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083891358
- Cited by
- 786
- References
- 0
- FWCI
- 77.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hsu, S. Y., Nakabayashi, K., Nishi, S., Kumagai, J., Kudo, M., Sherwood, O. D., & Hsueh, A. J. W. (2002). Activation of Orphan Receptors by the Hormone Relaxin. Science. https://doi.org/10.1126/science.1065654
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
