The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
CTCF, a Candidate Trans -Acting Factor for X-Inactivation Choice
Open accessAbstract
In mammals, X-inactivation silences one of two female X chromosomes. Silencing depends on the noncoding gene, Xist ( i nactive X - s pecific t ranscript), and is blocked by the antisense gene, Tsix . Deleting the choice/imprinting center in Tsix affects X-chromosome selection. Here, we identify the insulator and transcription factor, CTCF, as a candidate trans -acting factor for X-chromosome selection. The choice/imprinting center contains tandem CTCF binding sites that function in an enhancer-blocking assay. In vitro binding is reduced by CpG methylation and abolished by including non-CpG methylation. We postulate that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation.
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Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., & Tilghman, S. M. (2000) · Nature · doi:10.1038/35013106 · Cited by 1,547
Brown, C. J., Ballabio, A., Rupert, J. L., Lafreniere, R. G., Grompe, M., Tonlorenzi, R., & Willard, H. F. (1991) · Nature · doi:10.1038/349038a0 · Cited by 1,533
Requirement for Xist in X chromosome inactivation
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S., & Brockdorff, N. (1996) · Nature · doi:10.1038/379131a0 · Cited by 1,205
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101
Brockdorff, N., Ashworth, A., Kay, G. F., McCabe, V. M., Norris, D. P., Cooper, P. J., Swift, S., & Rastan, S. (1992) · Cell · doi:10.1016/0092-8674(92)90519-i · Cited by 1,026
Requirement for Xist in X chromosome inactivation
(1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81414-4 · Cited by 970
Chung, J. H., Whiteley, M., & Felsenfeld, G. (1993) · Cell · doi:10.1016/0092-8674(93)80052-g · Cited by 854
Tsix, a gene antisense to Xist at the X-inactivation centre
Lee, J., Davidow, L. S., & Warshawsky, D. (1999) · Nature Genetics · doi:10.1038/7734 · Cited by 829
Self-citation
Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
The many faces of histone lysine methylation
Lachner, M., & Jenuwein, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00335-6 · Cited by 819
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus
Splinter, E., Heath, H., Kooren, J., Palstra, R.-J., Klous, P., Grosveld, F., Galjart, N., & de Laat, W. (2006) · Genes & Development · doi:10.1101/gad.399506 · Cited by 677
X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease
Lee, J. T., & Bartolomei, M. S. (2013) · Cell · doi:10.1016/j.cell.2013.02.016 · Cited by 676
Self-citationInsulators: exploiting transcriptional and epigenetic mechanisms
Gaszner, M., & Felsenfeld, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1925 · Cited by 649
Metadata
- Authors
- Chao, W., Huynh, K. D., Spencer, R. J., Davidow, L. S., & Lee, J. T.
- Venue
- Science
- Published
- 2002-01-11
- Volume
- 295
- Issue
- 5553
- Pages
- 345-347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058151080
- Cited by
- 262
- References
- 26
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chao, W., Huynh, K. D., Spencer, R. J., Davidow, L. S., & Lee, J. T. (2002). CTCF, a Candidate Trans -Acting Factor for X-Inactivation Choice. Science. https://doi.org/10.1126/science.1065982
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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