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Cited by 789

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The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58

Wood, Derek W., Setubal, Joao C., Kaul, Rajinder, Monks, Dave E., Kitajima, Joao P., Okura, Vagner K., Zhou, Yang, Chen, Lishan, Wood, Gwendolyn E., Almeida, Nalvo F., Woo, Lisa, Chen, Yuching, Paulsen, Ian T., Eisen, Jonathan A., Karp, Peter D., Bovee, Donald, Chapman, Peter, Clendenning, James, Deatherage, Glenda, Gillet, Will, Grant, Charles, Kutyavin, Tatyana, Levy, Ruth, Li, Meng-Jin, McClelland, Erin, Palmieri, Anthony, Raymond, Christopher, Rouse, Gregory, Saenphimmachak, Channakhone, Wu, Zaining, Romero, Pedro, Gordon, David, Zhang, Shiping, Yoo, Heayun, Tao, Yumin, Biddle, Phyllis, Jung, Mark, Krespan, William, Perry, Michael, Gordon-Kamm, Bill, Liao, Li, Kim, Sun, Hendrick, Carol, Zhao, Zuo-Yu, Dolan, Maureen, Chumley, Forrest, Tingey, Scott V., Tomb, Jean-Francois, Gordon, Milton P., Olson, Maynard V., Nester, Eugene W.·2001·Science

Abstract

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.

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Metadata

Authors
Wood, D. W., Setubal, J. C., Kaul, R., Monks, D. E., Kitajima, J. P., Okura, V. K., Zhou, Y., Chen, L., Wood, G. E., Almeida, N. F., Woo, L., Chen, Y., Paulsen, I. T., Eisen, J. A., Karp, P. D., Bovee, D., Chapman, P., Clendenning, J., Deatherage, G., Gillet, W., Grant, C., Kutyavin, T., Levy, R., Li, M.-J., McClelland, E., Palmieri, A., Raymond, C., Rouse, G., Saenphimmachak, C., Wu, Z., Romero, P., Gordon, D., Zhang, S., Yoo, H., Tao, Y., Biddle, P., Jung, M., Krespan, W., Perry, M., Gordon-Kamm, B., Liao, L., Kim, S., Hendrick, C., Zhao, Z.-Y., Dolan, M., Chumley, F., Tingey, S. V., Tomb, J.-F., Gordon, M. P., Olson, M. V., & Nester, E. W.
Venue
Science
Published
2001-12-14
Volume
294
Issue
5550
Pages
2317-2323
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2149184205
Cited by
789
References
0
FWCI
69.75
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58. https://app.cochat.ai/papers/10.1126/science.1066804
The paper
Wood, D. W., Setubal, J. C., Kaul, R., Monks, D. E., Kitajima, J. P., Okura, V. K., Zhou, Y., Chen, L., Wood, G. E., Almeida, N. F., Woo, L., Chen, Y., Paulsen, I. T., Eisen, J. A., Karp, P. D., Bovee, D., Chapman, P., Clendenning, J., Deatherage, G., . . . Nester, E. W. (2001). The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58. Science. https://doi.org/10.1126/science.1066804

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