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Requirement of the Activation-Induced Deaminase ( AID ) Gene for Immunoglobulin Gene Conversion
Abstract
Three phenotypically distinct processes—somatic hypermutation, gene conversion, and switch recombination—remodel the functionally rearranged immunoglobulin (Ig) loci in B cells. Somatic hypermutation and switch recombination have recently been shown to depend on the activation-induced deaminase ( AID ) gene product. Here, we show that the disruption of the AID gene in the chicken B cell line DT40 completely blocks Ig gene conversion and that this block can be complemented by reintroduction of the AID complementary DNA. This demonstrates that the AID master gene controls all B cell–specific modifications of vertebrate Ig genes.
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Citations
Cited by
Ranjha, L., Howard, S. M., & Cejka, P. (2018) · Chromosoma · doi:10.1007/s00412-017-0658-1 · Cited by 325
Ranuncolo, S. M., Polo, J. M., Dierov, J., Singer, M., Kuo, T., Greally, J., Green, R., Carroll, M., & Melnick, A. (2007) · Nature Immunology · doi:10.1038/ni1478 · Cited by 278
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126
Alternative Adaptive Immunity in Jawless Vertebrates
Herrin, B. R., & Cooper, M. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903128 · Cited by 107
Lellek, H., Welker, S., Diehl, I., Kirsten, R., & Greeve, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203517200 · Cited by 13
Metadata
- Authors
- Arakawa, H., Hauschild, J., & Buerstedde, J.-M.
- Venue
- Science
- Published
- 2002-02-15
- Volume
- 295
- Issue
- 5558
- Pages
- 1301-1306
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085366207
- Cited by
- 469
- References
- 0
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arakawa, H., Hauschild, J., & Buerstedde, J.-M. (2002). Requirement of the Activation-Induced Deaminase ( AID ) Gene for Immunoglobulin Gene Conversion. Science. https://doi.org/10.1126/science.1067308
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