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Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
Open accessAbstract
Amyloid is associated with debilitating human ailments including Alzheimer's and prion diseases. Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid. The CsgA curlin subunit, purified in the absence of the CsgB nucleator, adopted a soluble, unstructured form that upon prolonged incubation assembled into fibers that were indistinguishable from curli. In vivo, curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery.
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[18] Quantification of β-sheet amyloid fibril structures with thioflavin T
LeVine, H. (1999) · Methods in Enzymology · doi:10.1016/s0076-6879(99)09020-5 · Cited by 1,365
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Metadata
- Authors
- Chapman, M. R., Robinson, L. S., Pinkner, J. S., Roth, R., Heuser, J., Hammar, M., Normark, S., & Hultgren, S. J.
- Venue
- Science
- Published
- 2002-02
- Volume
- 295
- Issue
- 5556
- Pages
- 851-855
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021785060
- Cited by
- 1,298
- References
- 1
- FWCI
- 15.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Chapman, M. R., Robinson, L. S., Pinkner, J. S., Roth, R., Heuser, J., Hammar, M., Normark, S., & Hultgren, S. J. (2002). Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation. Science. https://doi.org/10.1126/science.1067484
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
