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The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance
Abstract
Plant disease resistance ( R ) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene–triggered, Rar1 -dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin–F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
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Cited by
Firefly Luciferase Complementation Imaging Assay for Protein-Protein Interactions in Plants
Chen, H., Zou, Y., Shang, Y., Lin, H., Wang, Y., Cai, R., Tang, X., & Zhou, J.-M. (2008) · Plant Physiology · doi:10.1104/pp.107.111740 · Cited by 1,525
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
Inohara, N., Chamaillard, M., McDonald, C., & Nuñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 991
Thirty years of resistance: Zig-zag through the plant immune system
Ngou, B. P. M., Ding, P., & Jones, J. D. G. (2022) · The Plant Cell · doi:10.1093/plcell/koac041 · Cited by 961
Ubiquitin, Hormones and Biotic Stress in Plants
Dreher, K., & Callis, J. (2007) · Annals of Botany · doi:10.1093/aob/mcl255 · Cited by 503
Molecular players regulating the jasmonate signalling network
Lorenzo, O., & Solano, R. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.07.003 · Cited by 485
Metadata
- Authors
- Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze-Lefert, P.
- Venue
- Science
- Published
- 2002-03-15
- Volume
- 295
- Issue
- 5562
- Pages
- 2073-2076
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985212818
- Cited by
- 611
- References
- 0
- FWCI
- 69.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K., & Schulze-Lefert, P. (2002). The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance. Science. https://doi.org/10.1126/science.1067554
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